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| 1 | Dendritic cell deficiencies persist seven months after SARS-CoV-2 infection显示文摘Severe Acute Respiratory Syndrome Coronavirus(SARS-CoV)-2 infection induces an exacerbated inflammation driven by innate immunity components.Dendritic cells(DCs)play a key role in the defense against viral infections,for instance plasmacytoid DCs(pDCs),have the capacity to produce vast amounts of interferon-alpha(IFN-α).In COVID-19 there is a deficit in DC numbers and IFN-αproduction,which has been associated with disease severity.In this work,we described that in addition to the DC deficiency,several DC activation and homing markers were altered in acute COVID-19 patients,which were associated with multiple inflammatory markers.Remarkably,previously hospitalized and nonhospitalized patients remained with decreased numbers of CD1c+myeloid DCs and pDCs seven months after SARS-CoV-2 infection.Moreover,the expression of DC markers such as CD86 and CD4 were only restored in previously nonhospitalized patients,while no restoration of integrinβ7 and indoleamine 2,3-dyoxigenase(IDO)levels were observed.These findings contribute to a better understanding of the immunological sequelae of COVID-19. | Alberto Pérez-Gómez Joana Vitallé Carmen Gasca-Capote Alicia Gutierrez-Valencia María Trujillo-Rodriguez Ana Serna-Gallego Esperanza Muñoz-Muela María de los Reyes Jiménez-Leon Mohamed Rafii-El-Idrissi Benhnia Inmaculada Rivas-Jeremias Cesar Sotomayor Cristina Roca-Oporto Nuria Espinosa Carmen Infante-Domínguez Juan Carlos Crespo-Rivas Alberto Fernández-Villar Alexandre Pérez-González Luis Fernando López-Cortés Eva Poveda Ezequiel Ruiz-Mateos JoséMiguel Cisneros Sonsoles Salto-Alejandre Judith Berastegui-Cabrera Pedro Camacho-Martínez Carmen Infante-Domínguez Marta Carretero-Ledesma Juan Carlos Crespo-Rivas Eduardo Márquez JoséManuel Lomas Claudio Bueno Rosario Amaya JoséAntonio Lepe Jerónimo Pachón Elisa Cordero Javier Sánchez-Céspedes Manuela Aguilar-Guisado Almudena Aguilera Clara Aguilera Teresa Aldabo-Pallas Verónica Alfaro-Lara Cristina Amodeo Javier Ampuero María Dolores Avilés Maribel Asensio Bosco Barón-Franco Lydia Barrera-Pulido Rafael Bellido-Alba Máximo Bernabeu-Wittel Candela Caballero-Eraso Macarena Cabrera Enrique Calderón Jesús Carbajal-Guerrero Manuela Cid-Cumplido Yael Corcia-Palomo Juan Delgado Antonio Domínguez-Petit Alejandro Deniz Reginal Dusseck-Brutus Ana Escoresca-Ortega Fátima Espinosa Nuria Espinosa Michelle Espinoza Carmen Ferrándiz-Millón Marta Ferrer Teresa Ferrer Ignacio Gallego-Texeira Rosa Gámez-Mancera Emilio García Horacio García-Delgado Manuel García-Gutiérrez María Luisa Gascón-Castillo Aurora González-Estrada Demetrio González Carmen Gómez-González Rocío González-León Carmen Grande-Cabrerizo Sonia Gutiérrez Carlos Hernández-Quiles Inmaculada Concepción Herrera-Melero Marta Herrero-Romero Luis Jara Carlos Jiménez-Juan Silvia Jiménez-Jorge Mercedes Jiménez-Sánchez Julia Lanseros-Tenllado Carmina López Isabel López Álvaro López-Barrios Luis F.López-Cortés Rafael Luque-Márquez Daniel Macías-García Guillermo Martín-Gutiérrez Luis Martín-Villén JoséMolina Aurora Morillo María Dolores Navarro-Amuedo Dolores Nieto-Martín Francisco Ortega María Paniagua-García Amelia Peña-Rodríguez Esther Pérez Manuel Poyato Julia Praena-Segovia Rafaela Ríos Cristina Roca-Oporto Jesús F.Rodríguez María Jesús Rodríguez-Hernández Santiago Rodríguez-Suárez Ángel Rodríguez-Villodres Nieves Romero-Rodríguez Ricardo Ruiz Zida Ruiz de Azua Celia Salamanca Sonia Sánchez Víctor Manuel Sánchez-Montagut César Sotomayor Alejandro Suárez Benjumea Javier Toral | 2021 | Cellular & Molecular Immunology2021，18，9： | 2 |
| 2 | Effect of donor–recipient HLA matching at HLA A, B, C, and DRB1 on outcomes after umbilical-cord blood transplantation for leukaemia and myelodysplastic syndrome: a retrospective analysis显示文摘 | Mary Eapen John P Klein Guillermo F Sanz Stephen Spellman Annalisa Ruggeri Claudio Anasetti Maria Brown Richard E Champlin Joan Garcia-Lopez Gareth Hattersely Gesine Koegler Mary J Laughlin Gerard Michel Samir K Nabhan Franklin O Smith Mary M Horowitz Eli | 2011 | Lancet Oncology2011，，13： | 2 |
| 3 | Expression of cell cycle regulated proteins pRb2/pl30,p107,p27(kip1),p53,Mdm-2,and Ki-67(MIB-1)in prostatic gland adenocarcinoma显示文摘 | Claudio P P Zamparelli A Garcia F U | 2002 | Clin Cancer Res2002，8，6： | 1 |
| 4 | Coutinho critical assessment of the formation of ionic-liquid-based aqueous two-phase systems in acidic media显示文摘 | CLAUDIO A F M FERREIRA A M SHAHRIARI S FREIRE M G JOAO A P | 2011 | J Phys Chem B2011，115，11： | 1 |
| 5 | Trajectories associated toregional and extra-regional pollen transport in the southeastof Buenos Aires Province,Mar del Plata(Argentina)显示文摘 | María I Gassmann Claudio F P | 2006 | In-ternational Journal of Biometeorology2006，50，： | 1 |
| 6 | VOCs removal from waste gases: gas-phase bioreaetor for the abatement of hexane by Aspergillus niger 显示文摘 | Giorgia S Claudio P Daria F M | 2003 | Chemical Engineering Science2003，58，： | 1 |
| 7 | Carbohydrate synthesis by two Navicula strains isolated from benthic and pelagic mucilages in the Tyrrhenian Sea (Tuscan Archipelago)显示文摘 | Cecilia F Roberto D P Claudio S | 2003 | Applied Phycology2003，，15： | 1 |
| 8 | Permanent scatters in SAR interferometry 显示文摘 | Ferretti A Claudio P Rocca F | 2001 | IEEE Transactions on Geosei- ence and Remote Sensing2001，39，1： | 1 |
| 9 | Carbohydrate synthesis by two Navicula strains isolated from benthic and pelagic mucilages in the Tyrrhenian Sea ( Tuscan Archipelago ) 显示文摘 | Cecilia F Roberto D P Claudio S | 2003 | Applied Phycology2003，，15： | 1 |
| 10 | Adenoviral RB2/P130 gene transfer inhibits smooth muscle cell proliferation and prevents restenosis after angioplasty显示文摘 | Claudio P P Fratta L Farina F et a1 | 1999 | Circ Res1999，85，11： | 1 |
| 11 | Detrital zircon ages of the Neoproterozoie sedimentary successions in Uruguay and Argentina:Insights into the geological evolution of the Rio delaPlata Craton显示文摘 | Claudio G Stanley C F Daniel G P | 2008 | Precambrian Research2008，167，： | 1 |
| 12 | Colorectal cancer microenviron- ment among nutrition, gut microbiota, inflammation and epige- netics 显示文摘 | Paalo G Chiara P Claudio F | 2013 | Curt Pharm Des2013，19，4： | 1 |
| 13 | Effects of volume resuscitation on splanchnic perfusion in canine model of severe sepsis induced by live Escherichia coli infusion 显示文摘 | Claudio E L Luiz F P Ray J | 2004 | Crit Care2004，8，4： | 1 |
| 14 | Expression of cell-cycle-regulated proteins pRb2/p130, p107, p27 ( kipl ), p53, mdm-2, and Ki-67(MIB-1) in prostatic gland adenocarcinoma显示文摘 | Claudio P P Zamparelli A Garcia F U | 2002 | Clin Cancer Res2002，8，6： | 1 |
| 15 | Nonlinear subsidence rate estimation using permanent scatters in differential sar interferometry显示文摘 | Ferretti A Claudio P Rocca F | 2000 | IEEE Transactions on Geoscience and Remote Sensing2000，38，5： | 1 |
| 16 | Global transient stabilityconstrained optimal power flow using an OMIB reference trajectory 显示文摘 | ALEJANDRO P M CLAUDIO R F E DANIEL R V | 2010 | IEEE Transactions on Power Systems2010，25，1： | 1 |
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