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| 1 | Sporadic versus hereditary gastrinomas of the duodenum and pancreas: Distinct clinico-pathological and epidemiological features显示文摘Gastrinomas are defined as gastrin secreting tumors that are associated with Zollinger-Ellison syndrome (ZES). ZES is characterized by elevated fasting gastrin serum levels, positive secretin stimulation test and clinical symptoms such as recurrent peptic ulcer disease, gastroesophageal re?ux disease and occasional diarrhea. Genetically, nonhereditary (sporadic) gastrinomas are distinguished from hereditary gastrinomas, which are associated with multiple endocrine neoplasia type 1 (MEN1) syndrome. In general, duodenal gastrinomas are small and solitary if they are sporadic and multiple as well as hereditary. The sporadic gastrinomas occur in the duodenum or in the pancreas while the hereditary gastrinomas almost all occur in the duodenum. Our series of 77 sporadic duodenal neuroendocrine tumors (NETs) includes 18 patients (23.4%) with gastrinomas and ZES. Of 535 sporadic NETs in the pancreas collected from the NET archives of the departments of pathology in Zürich, Switzerland, and Kiel, Germany, 24 patients (4.5%) suffered from sporadic pancreatic gastrinomas and ZES. These NETs have to be distinguished fromtumors with immunohistochemical positivity for gastrin but without evidence of ZES. An additional 19 patients suffered from MEN1 and ZES. These patients showed exclusively duodenal gastrinomas, but not pancreatic gastrinomas. The prognosis of sporadic and MEN1- associated duodenal gastrinomas is better than that of pancreatic gastrinomas, since they progress slowly to liver metastasis. In summary, sporadic and MEN1- associated gastrinomas in the duodenum and pancreas show different clinico-pathological and genetic features. The incidence of sporadic duodenal gastrin-producing tumors is increasing, possibly due to optimized diagnostic procedures. In contrast, pancreatic MEN1- associated gastrinomas seem to be extremely rare. A considerable subset of tumors with immunohistochemical expression of gastrin but without evidence of ZES should be designated as functionally inactive NETs expressing gastrin, but not as gastrinomas. | Martin Anlauf Nele Garbrecht Tobias Henopp Anja Schmitt Regina Schlenger Andreas Raffel Markus Krausch Oliver Gimm Claus F Eisenberger Wolfram T Knoefel Henning Dralle Paul Komminoth Philipp U Heitz Aurel Perren Günter Klppel | 2006 | World Journal of Gastroenterology2006，12，34： | 7 |
| 2 | Correlation opti- mized warping and dynamic time warping as preprocessing methods for chromatographic data 显示文摘 | GIORGIO T FRANS VAN DEN B CLAUS A | 2004 | Journal of Chemometrics2004，18，5： | 1 |
| 3 | Interpleural analgesia doesnot influence postthoracotomy pain 显示文摘 | Silomon M Claus T Huwer H | 2000 | Anesth Analg2000，91，1： | 1 |
| 4 | Estrogens and prostaglandin F2a in the semen and blood plasma of stallions显示文摘 | Claus R Dimmick MA Gimenez T Hudson LW | 1992 | Theriogenology1992，，38： | 1 |
| 5 | Structural Control: past, present, and future显示文摘 | Housner G Bergman L Gaughey T Chassiakos A Claus R Masri S Skellton R Soong T Spencer B Yao J | 1997 | Journal of Engineering Mechanics (ASCE)1997，123，： | 1 |
| 6 | Product innovation through coopetition in alliances: Singular or plural governance?显示文摘 | Bouncken R B Clau T Fredrich V | 2016 | Industrial Marketing Management2016，53，： | 1 |
| 7 | A role for the pseudokinaseHER3 in the acquired resistance against EGFR- andHER2-directed targeted therapy 显示文摘 | Claus J Patel G Ng T | 2014 | Biochem Soc Trans2014，42，4： | 1 |
| 8 | Interpleural analgesia does not influence postthoracotomy pain显示文摘 | SILOMON M CLAUS T HUWER H | | 0，，01： | 1 |
| 9 | Simple and reliable procedure for PCR amplification of genomic DNA from yeast cells using short sequencing primer显示文摘 | Haaning Jesper Oxvig Claus Overgaard M T | 1997 | Biochemistry and Moclecular Biology Inter - national1997，42，1： | 1 |
| 10 | A dual role of extraeellu- lar DNA during biofilrn formation of Neisseria meningitides显示文摘 | Lappann M Claus H Van Alen T | 2010 | Mol Microbiol2010，75，6： | 1 |
| 11 | Structural Control: Past, Present, and Future显示文摘 | HOUSNER G W BERGMAN L A CAUGHEY T K CHASSIAKOS A G CLAUS R O MASRI S F SKELTON R E SOONG T T SPENCER B F YAO J T P | 1997 | Journal of Engineering Mechanics1997，123，9： | 1 |
| 12 | Low-dose levalbuterol in children with asthma:safety and efficacy in comparison with placebo and racemic albuterol显示文摘 | Milgrom H Skoner D P Bensch G Kim K T Claus R Baumgartner RA for the evalbuterol Pediatric Study Group | 2001 | Allergy Clin Immunol2001，108，： | 1 |
| 13 | Analysis of family of cyclin-Dependent kinase inhibitors: p15/MTS2/^INK4B, p16/MTS 1/INK4A, and p18 Genens in Acute lymphoblastic leukemia of childhood显示文摘 | Takeuch S Claus R Bartram T | 1995 | Blood1995，86，2： | 1 |
| 14 | Lactate in a laubenpieper 显示文摘 | Derer W Elitok S Claus T | 2005 | Nephrol Dial Transplant2005，20，12： | 1 |
| 15 | Immediate effects of n-3 fatty acid infu- sion on the induction of sustained ventricular tachycar- dia显示文摘 | Schrepf R Lirnmert T Claus Weber P Theisen K Sellmayer A | 2004 | Lancet2004，363，： | 1 |
| 16 | A dual role of extracellular DNA during biofilm formation of Neisseria meningitidis 显示文摘 | Lappann M Claus H van Alen T | 2010 | Mol Microbiol2010，75，6： | 1 |
| 17 | Novel dry powder inhalation system based on dispersion of lyophilisates 显示文摘 | Claus S Schoenbrodt T Weiler C | 2011 | EurJPharm Sci2011，43，12： | 1 |
| 18 | Structural Control: Past, Present, and Future 显示文摘 | Housner G W Bergman L A Caughey T K Chassiakos A G Claus R O Masri S F Skelton R E Soong T T Spencer B F Yao J T P | 1997 | Journal of Engineering Mechanics1997，123，9： | 1 |
| 19 | Structure Control: Past, Present, and Future 显示文摘 | Housner G W Bergman L A Caughey T K Chassiakos AG Claus R O Skehon RE Soong T T Spencer B F YaoJ T P | 1997 | Journal of Engineering Mechanics1997，123，9： | 1 |
| 20 | Cell kinetic in epithelium and stroma of benign prostatic hyperplasia显示文摘 | Claus S Berges R Senge T | 1997 | Urology1997，158，1： | 1 |
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