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| 1 | Dysfunctional stem and progenitor cells impair fracture healing with age显示文摘Successful fracture healing requires the simultaneous regeneration of both the bone and vasculature;mesenchymal stem cells (MSCs) are directed to replace the bone tissue, while endothelial progenitor cells (EPCs) form the new vasculature that supplies blood to the fracture site. In the elderly, the healing process is slowed, partly due to decreased regenerative function of these stem and progenitor cells. MSCs from older individuals are impaired with regard to cell number, proliferative capacity, ability to migrate, and osteochondrogenic differentiation potential. The proliferation, migration and function of EPCs are also compromised with advanced age. Although the reasons for cellular dysfunction with age are complex and multidimensional, reduced expression of growth factors, accumulation of oxidative damage from reactive oxygen species, and altered signaling of the Sirtuin-1 pathway are contributing factors to aging at the cellular level of both MSCs and EPCs. Because of these geriatric-specific issues, effective treatment for fracture repair may require new therapeutic techniques to restore cellular function. Some suggested directions for potential treatments include cellular therapies, pharmacological agents, treatments targeting age-related molecular mechanisms, and physical therapeutics. Advanced age is the primary risk factor for a fracture, due to the low bone mass and inferior bone quality associated with aging;a better understanding of the dysfunctional behavior of the aging cell will provide a foundation for new treatments to decrease healing time and reduce the development of complications during the extended recovery from fracture healing in the elderly. | Diane R Wagner Sonali Karnik Zachary J Gunderson Jeffery J Nielsen Alanna Fennimore Hunter J Promer Jonathan W Lowery M Terry Loghmani Philip S Low Todd O McKinley Melissa A Kacena Matthias Clauss Jiliang Li | 2019 | World Journal of Stem Cells2019，11，6： | 3 |
| 2 | Stiff macromolecules with aliphatic side-chains-side-chian mobility, conformation, and organization from 2D solid-state NMR spectroscopy显示文摘 | Clauss J Schmidtrohr K Adam A | 1992 | Macromolecules1992，25，20： | 1 |
| 3 | The evolution of a genetic locus encoding small serine proteinase inhibitors 显示文摘 | Clauss A Lilja H Lundwall A | 2005 | Biochem Biophys Res Commun2005，333，2： | 1 |
| 4 | Phenotype and course of hutchinson-gilford progeria syndrome显示文摘 | Merideth M A Gordon L B Clauss S | 2008 | N Engl J Med2008，358，6： | 1 |
| 5 | Orodental phenotype and genotype findings in all subtypes of hypophosphatasia显示文摘 | Reibel A Manière MC Clauss F | 2009 | Orphanet J Rare Dis2009，4，： | 1 |
| 6 | Structural and functional differences in various divisions of the rabbit colon 显示文摘 | Snipes RL Clauss W Weber A | 1982 | Cell Tissue Res1982，225，2： | 1 |
| 7 | A combined region growing and deformable model method for extraction of closed surfaces in 3D CT and MRI scans显示文摘 | FRESNO M VENERE M CLAUSSE A | 2009 | Computerized Medical Imaging and Graphics2009，33，5： | 1 |
| 8 | A locus on human chromosome 20 contains several genes expressing protease inhibitor domains with homology to whey acidic protein显示文摘 | Clauss A Lilja H Lundwall A | 2002 | Biochem J2002，368，1： | 1 |
| 9 | Determination of ambroxol in an automated multi-pumping pulsed flow system显示文摘 | Santos JL Clausse A Llma JL | 2005 | Jap Socie Analytic Chem2005，21，： | 1 |
| 10 | The vaccine candidate BLSOmp31 protects mice against Brucella canis infection显示文摘 | CLAUSSE M DIAZ A G GHERSI G | 2013 | Vaccine2013，31，51： | 1 |
| 11 | A locus on human chromosome 20 contains several genes expressing protease inhibitor domains with homology to whey acidic protein显示文摘 | Clauss A Lilja Lundwall A | 2002 | Biochem J2002，368，1： | 1 |
| 12 | Custom cerium oxide nanoparticles protect against a rice radical mediated autoimmune degenerative disease in the brain 显示文摘 | Heckman K L DeCoteau W Estevez A Reed K J Costanzo W Sanford D Leiter J C Clauss J Knapp K Gomez C Mullen P Rathbun E Prime K Marini J Patchefsky J Patchefsky A S Hailstone R K Erli- chman J S | 2013 | ACS Nano2013，7，10： | 1 |
| 13 | Determination of ambroxol in an automated multi-pumping pulsed flow system显示文摘 | Santos JL Clausse A Lima JL | 2005 | The Japan Society for Analytical Chemistry2005，21，4： | 1 |
| 14 | A locus on human chromosome 20 contains several genes expressing pro- tease inhibitor domains with homology to whey acidic protein 显示文摘 | Clauss A Lilja H Lundwall A | 2002 | Biochem J2002，368，1： | 1 |
| 15 | Dunnste Kohlenstoff-Folien显示文摘 | Boehm H P Clauss A Hofmann U | 1962 | Zeitschrift Für Naturforschung B1962，17，3： | 1 |
| 16 | Urokinase-type plas-minogen activator receptor:a beacon of malignancy显示文摘 | Drapkin R Clauss A Skates S | 2008 | Clin Cancer Res2008，14，18： | 1 |
| 17 | Natural Variation in MAM Within and Between Populations of Ar abidopsis @rata Determines Glucosinolate Phenotype 显示文摘 | HEIDEL A J CLAUSS M J KROYMANN J | 2006 | Genetics2006，173，3： | 1 |
| 18 | A novel vascular endothelial growth factor encoded of virus,VEGF-E,mediates angiogenesis via signaling through VEGFR-2(KDR)but not VEGFR-1(Flt-l)receptor tyrosine kinases显示文摘 | MEYER M Clauss M LEPPLE-WIENHUES A | 1999 | EMBO J1999，18，： | 1 |
| 19 | A novel vascular endothelial growth factor encoded by Off virus, VEGF-E, mediates angiogenesis via signaling through VEGFR-2 (KDR) but not VEGFR-1 ( Flt-1 ) receptor tyrosine kinases 显示文摘 | Meyer M Clauss M Lepple-Wienhues A | 1999 | EMBO J1999，18，2： | 1 |
| 20 | A novel vascular endothelial growth factor encoded by Orfvirus,VEGF-E,mediates angiogenesis via signaling through VEGFR-2 (KDR) but not VEGFR-1 (Flt-1)receptor tyrosine kinases显示文摘 | Meyer M Clauss M Lepple-Wienhues A | 1999 | EMBO J1999，18，2： | 1 |
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