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| 1 | Integrated approach to colorectal anastomotic leakage: Communication, infection and healing disturbances显示文摘Colorectal anastomotic leakage(CAL) remains a major complication after colorectal surgery. Despite all efforts during the last decades, the incidence of CAL has not decreased. In this review, we summarize the available strategies regarding prevention, prediction and intervention of CAL and categorize them into three categories: communication, infection and healing disturbances. These three major factors actively interact during the onset of CAL. We aim to provide an integrated approach to CAL based on its etiology. The intraoperative air leak test, intraoperative endoscopy, radiological examinations and stoma construction mainly aim to detect and to prevent communication between the intra- and extra-luminal content. Other strategies including postoperative drainage, antibiotics, and infectious-parameter evaluation are intended to detect and prevent anastomotic or peritoneal infection. Most currently available interventions for CAL focus on the control of communication and infection, while strategies targeting the healing disturbances such as lifestyle changes, oxygen therapy and evaluation of metabolic biomarkers still lack wide clinical application. This simplified categorization may contribute to an integrated understanding of CAL. We strongly believe that this integrated approach should be taken into consideration during clinical practice. An integrated approach to CAL could contribute to a better understanding of the etiology of CAL and eventually better patient outcome. | Cloe L Sparreboom Zhou-Qiao Wu Jia-Fu Ji Johan F Lange | 2016 | World Journal of Gastroenterology2016，22，32： | 9 |
| 2 | Novel brOnsted acidic ionic liquids and their use as dual solvent-catalysts 显示文摘 | Cloe A C Jensen J L | 2002 | J Am Chem See2002，124，21： | 1 |
| 3 | Preliminary experience with highvolume hemofihration in human septic shock显示文摘 | Bellomo R Baldwin I Cloe L | 1998 | Kidney Int1998，53，66： | 1 |
| 4 | Pre- liminary experience with highvolume hemofilatation in human septic shock显示文摘 | Bellomo R Baldwin I Cloe L | 1998 | Kidey Im1998，53，： | 1 |
| 5 | Preliminary experience with high-volume hemofiltration in human septic shock显示文摘 | Bellomo R Baldwin I Cloe L | 1998 | Kidney Int1998，53，66： | 1 |
| 6 | Preliminary experience with high-volume hemofihration in human septic shock 显示文摘 | Bellomo R Baldwin I Cloe L | 1998 | Kidney Int1998，53，66： | 1 |
| 7 | Preliminary experience with high- volume hemofilatation in human septic shock显示文摘 | Bellomo R Baldwin I Cloe L | 1998 | Kidney Int Suppl1998，66，： | 1 |
| 8 | Biphasic and discontinuous injection of contrast material for thin-section helical CT angiography of the whole aorta and iliac arteries显示文摘 | Cloe Y H Phyun L H Han B K | 2001 | A JR2001，176，2： | 1 |
| 9 | Preliminary experience with highvolume hemofilatation in human septic shock显示文摘 | Bellomo R Baldwin I Cloe L | 1998 | Kidey Int1998，53，： | 1 |
| 10 | Preliminary experience with highvolume hemofilatration in human septic shock 显示文摘 | Baldwin I Cloe L | 1998 | Kidney Int1998，53，66： | 1 |
| 11 | Pre liminary experience with high-volume hemofilatration in human septic shock显示文摘 | Bellomo R Baldwin I Cloe L | 1998 | Kidney Int1998，53，： | 1 |
| 12 | Preliminary experience with high-volume hemofiltration in human septic shock显示文摘 | Bellomo R Baldwin I Cloe L | 1998 | Kidney Int1998，53，66： | 1 |
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