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| 1 | 曲马多治疗糖尿病性神经疼痛的双盲随机试验显示文摘目的 :本研究旨在评价曲马多治疗糖尿病性神经痛的有效性和安全性。背景 :糖尿病性神经痛是糖尿病患者的主要症状 ,其治疗和其他的末梢神经病变一样 ,不能令人满意。曲马多是作用于中枢的镇痛剂 ,用于治疗中到重度疼痛。方法 :多中心、门诊病例、随机、双盲、安慰剂做对照、设置平行组的研究 ,包括清洗期 (在此期间停用所有镇痛剂 )和一个为期 42天的双盲治疗期。总共有 1 31名患糖尿病性神经痛的患者按每日 4次接受了曲马多 (n =65)或看上去与曲马多相同的安慰剂胶囊治疗 (n =66)。 42天的治疗结束后或治疗中断后比较曲马多组和安慰剂组平均疼痛强度评分作出主要有效性分析 ;次要有效性分析为疼痛缓解率评分和根据日常活动和睡眠状况作出的对生活质量的评估。结果 :曲马多平均剂量为 2 1 0mg/天 ,治疗糖尿病性神经痛较安慰剂有显著疗效 (P≤ 0 .0 0 1 )。曲马多组患者生理(P =0 .0 2 )和社会功能 (P =0 .0 4 )的评分显著优于安慰剂组。未发现对睡眠有显著治疗作用。曲马多最常见的不良反应是恶心 ,便秘 ,头疼和嗜睡。结论 | Harati Y Gooch C Swenson M Green D Raskin P Donofrio P Cornblath D Sachdeo R Siu CO Kamin M | 2001 | 中国疼痛医学杂志2001，7，1： | 2 |
| 2 | Regulatory volume de- crease in Trypanosoma cruzi involves amino acid efflux and changes in intracellular calcium 显示文摘 | Rohloff P Rodrigues CO Docampo R | 2003 | Mol Biochem Parasitol2003，126，2： | 1 |
| 3 | Rapid changes in polyphos- phate content within acidocaleisomes in response to cell growth, differentiation, and environmental stress in Trypanoso- ma cruzi显示文摘 | Ruiz FA Rodrigues CO Doeampo R | 2001 | J Biol Chem2001，276，26： | 1 |
| 4 | Ras pathway activation in gliomas:a strategic target for intranasal administration of perillyl alcohol显示文摘 | Da Fonseca CO Linden R Futuro D | | 0，，04： | 1 |
| 5 | Cost anal- ysis of open radical cystectomy versus robot-assisted radi- cal eysteetomy显示文摘 | Mmeje CO Martin AD Nunez-Nateras R | 2013 | Curt Urol Rep2013，14，1： | 1 |
| 6 | Phase II safety and immunogenicity study of live chikungunya virus vaccine TSI-GSD-218 显示文摘 | Edelman R Tacket CO Wasserman SS Bodison SA Perry JG Mangiafico JA | 2000 | Am J Trop Med Hyg2000，62，6： | 1 |
| 7 | Phase 1 stuies of Walter Reed Army Institute of Research can didate attenuted dengue vaccines: selection of safe and immunogenic monovalent vaccines 显示文摘 | Kanesa-Thasan N Edelman R Tacket CO | 2003 | Am J Trop Med Hyg2003，69，6： | 1 |
| 8 | Lack of antioxidant activity of the antiatherogenic compound L-arginine 显示文摘 | ADAMS M R CO V P ROLAND S | 1999 | Atherosclerosis1999，146，2： | 1 |
| 9 | The Robustness of CAN-Q in Modeling Automated Manufacturing Systems 显示文摘 | Co H C Wysk R A | 1986 | International Journal of production Research1986，，10： | 1 |
| 10 | New Fast GPS Code - Acquisition Technique Using FFT显示文摘 | Van Nee D J R Co - enen A J R M | 1991 | Electronic Letters1991，27，2： | 1 |
| 11 | A role for CIM + CD25 + T ceils in regulation of the immune response dur- ing hum an tuberculosis显示文摘 | Ribeiro- Rodrignes R Rescnde Co T Rojas R | 2006 | Clin Exp Immunol2006，144，： | 1 |
| 12 | Cystatin C concentration as a risk factor for heart failure in older adults显示文摘 | Katz R Stehman-Breen CO | 2005 | Ann Intern Med2005，142，7： | 1 |
| 13 | Recurrent hematomas following craniotomy for traumatic intracranial mass显示文摘 | Bullock R Hannemann CO Murray L et a1 | 1990 | J Neurosurg1990，72，： | 1 |
| 14 | Physical andchemical properties of chufa (Cyperusesculentus L) tubersgrown in the ^ukurova region of Turkey显示文摘 | Co§kuner Y Ercan R Karababa E | 2002 | J Sci FoodAgri2002，82，： | 1 |
| 15 | Frequency, correlates and clinical implications of myocardial perfusion after primary angioplasty and stenting, with and without glycoprotein II b/III a inhibition in acute myocardial infarction显示文摘 | Costantini CO Stone GW Mehran R | 2004 | J Am Cull Cardiol2004，44，2： | 1 |
| 16 | The human proteomics initistive(HPI)显示文摘 | Donovan CO Apweiler R Bairoch A | 2001 | Trends Biotechnol2001，19，5： | 1 |
| 17 | Cystatin C concentration as a risk factor for heart failure in older adults显示文摘 | Sarnak MJ Katz R Stehman-Breen CO | 2005 | Ann Intern Med2005，142，7： | 1 |
| 18 | Inhibition of cyclooxygenase2by nime- sulide improves cognitive outcome more than motor out - come follow- ing diffuse traumatic brain injury in rats 显示文摘 | I Cernak CO Connor R Vink | 2002 | ExpBrain Res2002，147，2： | 1 |
| 19 | Cystatin Cconcentrati On as arisk factor for heart failure in older adults显示文摘 | Sarnak MJ Katz R Stehman-Breen CO et a1 | 2005 | Ann Intern Med2005，142，： | 1 |
| 20 | Characterization of late acyltransferase aenes of Yersinia pestis and their role in temperaturedependent LipidA variation显示文摘 | Rebeil R Ernst RK Jarrett CO | 2006 | J Bacteriol2006，188，4： | 1 |
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