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| 1 | The impact of the sleep apnea syndrome on oxidant-antioxidant balance in the blood of overweight and obese patients显示文摘 | Wysocka E Cofta S Cymerys M | 2008 | J Physiol Pharmacol2008，59，： | 1 |
| 2 | The impact of the sleep apnea syndrome on oxidant-antioxidant balance in the blood of overweight and obese patients 显示文摘 | Wysocka E Cofta S Cymerys M | 2008 | J Physiol Pharmacol2008，596，： | 1 |
| 3 | Differential expression of mucin 1 and mucin 2 in colorectal cancer显示文摘AIM To determine tissue expression(mRNA, protein) of two types of mucins [mucin 1(MUC1) and mucin 2(MUC2)] in patients with colorectal cancer(CRC).METHODS Expression of membrane-bound mucin(MUC1) and secretory mucin(MUC2) in CRC(mRNA, protein) were analyzed in tissue material including fragments of tumorsobtained from CRC patients(n = 34), and fragments of normal colorectal tissue from the same patients(control). The analysis was conducted using real-time quantitative polymerase chain reaction(RT-qPCR)(transcripts), immunohistochemistry(IHC)(apomucins), and the modern approach for morphometric analysis of IHC reaction(HSV filter software). Results on tissue expression of both mucins(mRNA, protein) were compared to histological alterations in colorectal cancer samples and correlated with selected clinical data in the patients. The statistical analysis was conducted using Statistica PL v. 12.0 software.RESULTS Significantly higher expression of the MUC1 mRNA in the CRC, compared with the control and the borderline correlation of mRNA expression with MUC1 protein levels in colorectal samples was observed. The expression of apomucins concerned cell membranes(MUC1) and cytoplasm(MUC2) and occurred both in control tissues and in most cancerous samples. There were no significant relationships between MUC1(mRNA, protein) and the clinicopathological data of patients. MUC2 protein expression was significantly lower as compared to the control, while MUC2 mRNA expression was comparable in both groups. The MUC1/MUC2 ratio was significantly higher in CRC tissues than in the control. The higher expression of MUC2 was a feature of mucinous CRC subtypes, and characterized higher histological stage of tumors. Negative correlations have been obtained between MUC2 and the Ki-67 antigen, as well as between MUC2 and p53 protein expressions in CRC.CONCLUSION A combination of tissue overexpression of MUC1, reduced MUC2 expression, and high ratio of MUC1/MUC2 is a factor of poor prognosis in CRC patients. MUC2 tissue expression allows to differentiate mucinous and nonmucinous CRC subtypes. | Aldona Kasprzak Elzbieta Siodla Malgorzata Andrzejewska Jacek Szmeja Agnieszka Seraszek-Jaros Szczepan Cofta Witold Szaflarski | 2018 | World Journal of Gastroenterology2018，24，36： | 1 |
| 4 | Lung impairment in scleroderma显示文摘 | Piorunek T Kuznar-Kaminska B Cofta S | | 0，，： | 1 |
| 5 | The impact of the sleep apnea syndrome on oxidant-antioxidant balance in the blood of overweight and obese patients 显示文摘 | Wysocka E Cofta S Cymerys M | 2008 | J Physiol Pharmacol2008，596，： | 1 |
| 6 | The impact of the sleep apnea syndrome on oxidant-antioxidant balance in the blood of overweight and obese patients 显示文摘 | Wysocka E Cofta S Cymerys M | 2008 | J Physiol Pharmacol2008，59，6： | 1 |
| 7 | Oxidative stress markers in the blood of persons with different stages of obstructive sleep apnea syndrome显示文摘 | Cofta S Wysocka E Piorunek T | 2008 | J Physiol Pharmacol2008，596，： | 1 |
| 8 | The evaluation of selected serum mineral concentrations and their association with insulin resistance in obese adolescents显示文摘 | SULIBURSKA J COFTA S GAJEWSKA E | 2013 | Eur Rev Med Pharmacol Sci2013，17，17： | 1 |
| 9 | Oxidative stress markers in the blood of persons with different stages of obstructive sleep ap- nea syndrome 显示文摘 | Cofta S Wysocka E Piorunek T | 2008 | J Physiol Pharmacol2008，59，6： | 1 |
| 10 | Endothelium-de- rived markers and antioxidant status in the blood of ob- structive sleep apnea males显示文摘 | Cofta S Wysocka E Michalak S | 2009 | Eur J Med Res2009，14，4： | 1 |
| 11 | The evaluation of selected serum mineral concentrations and their association with insulin resistance in obese adolescents 显示文摘 | Suliburska J Cofta S Galewska E | 2013 | Eur Rev Med Phamacol Sci2013，17，17： | 1 |
| 12 | Blood antioxidant status, dysglycemia and obstructive sleep apnea显示文摘 | WYSOCKA E COFTA S PIORUNEK T | 2013 | Adv Exp Med Biol2013，756，： | 1 |
| 13 | Oxidative stress marker in the blood of persons with different stages of obstructive sleep apnea syndrome显示文摘 | Cofta S Wysocka E Piorunek T | 2008 | J Physiol Pharmacol2008，59，6： | 1 |
| 14 | Adipocytokines in sleep apnea syndrome显示文摘 | Wysocka E Cofta S Dziegielewska S | 2009 | Eur J Med Res2009，14，4： | 1 |
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