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| 1 | WJBC 5^(th) Anniversary Special Issues(2): Proteomics In 2014, can we do better than CA125 in the early detection of ovarian cancer?显示文摘Ovarian cancer is a lethal gynecologic malignancy with greater than 70% of women presenting with advanced stage disease. Despite new treatments, long term outcomes have not significantly changed in the past 30 years with the five-year overall survival remaining between 20% and 40% for stage Ⅲ and Ⅳ disease. In contrast patients with stage Ⅰ disease have a greater than 90% five-year overall survival. Detection of ovarian cancer at an early stage would likely have significant impact on mortality rate. Screening biomarkers discovered at the bench have not translated to success in clinical trials. Existing screening modalities have not demonstrated survival benefit in completed prospective trials. Advances in high throughput screening are making it possible to evaluate the development of ovarian cancer in ways never before imagined. Data in the form of human '-omes' including the proteome, genome, metabolome, and transcriptome are now available in various packaged forms. With the correct pooling of resources including prospective collection of patient specimens, integration of high throughput screening, and use of molecular heterogeneity in biomarker discovery, we are poised to make progress in ovarian cancer screening. This review will summarize current biomarkers, imaging, and multimodality screening strategies in the context of emerging technologies. | Joshua G Cohen Matthew White Ana Cruz Robin Farias-Eisner | 2014 | World Journal of Biological Chemistry2014，5，3： | 18 |
| 2 | 从附睾到卵子:CRISP蛋白在哺乳动物受精过程中的作用显示文摘哺乳动物的受精过程涉及精卵结合的很多步骤,是一个非常复杂的过程,其分了机制亟待阐明。此篇综述主要论述了CRISP(富含半胱氨酸的分泌蛋白)作为模型分子在哺乳动物受精过程中的价值。大量的体外实验和基因敲出模型研究显示,附睾内的CRISP1以两种不同的亲和力结合于精子表面,参与精子获能、精子-透明带结合、精卵融合的调控。这些研究成果可以延伸至人类。我们住研究中发现,人类具有与啮齿类同源的CRISP(hCRISP1),同样参与受精过样。CRISP家族的其他成员(睾丸内CRISP2、附挈内CRISP3—4、射精时的CRISP3)也参与了精卵结合的过程,提示同源分子间的相互协同有助于受精的成功。另外,我们的研究显示,CRISP蛋白伴随精子穿越男性及女性生殖管道的全过程。我们推测CRISP不仅参与了受精过程,而且可能成为不育和避孕研究的新靶点。 | Vanina G Da Ros Mariana Weigel Munoz Maria A Battistone Nicolas G Brukman Guillermo Carvajal Ludmila Curci Matlas D Gomez-Elias Debora J Cohen Patricia S Cuasnicu | 2015 | Asian Journal of Andrology2015，17，5： | 5 |
| 3 | Fondaparinux预防老年急性内科患者发生静脉血栓形成的效果与安全性:随机安慰剂对照研究显示文摘目的:观察 Fondaparinux 对具有中高度静脉血栓发生危险的老年急性内科住院患者的抗凝效果与安全性。设计:双盲随机安慰剂对照研究。背景:8个国家的35个中心。参与者:849例≥60岁内科患者,住院原因分别为充血性心力衰竭、慢性肺病合并急性呼吸系统疾患、急性炎症性或感染性疾病,预期至少住院4天以上。干预:2.5 mg Fondaparinux 或安慰剂,每天1次皮下注射,持续6~14天。观察指标:主要指标为静脉血栓形成(治疗后15天内采用双侧静脉造影检查)及有症状的静脉血栓;次要指标为死亡与出血。患者随访时间为1个月。结果:Fondaparinux 治疗组425例患者和安慰剂组414例患者接受了安全性分析(10例未治疗)。644例患者(75.9%)可接受主要指标分析。静脉血栓检出率在 Fondaparinux 治疗组为5.6%(18/321),安慰剂组为10.5%(34/323),相对危险减少46.7%(95% CI 7.7%~69.3%)。安慰剂组5例患者发生有症状的静脉血栓,Fondaparinux治疗组无患者发生有症状的静脉血栓(P=0.029)。两组均有1例(0.2%)患者发生严重出血。随访结束时,安慰剂组、Fondaparinux 治疗组分别死亡25(6.0%)、14(3.3%)例患者。结论:Fondaparinux 可有效预防急性内科老年患者无症状性及有症状的静脉血栓。严重出血几率两组相似。 | Alexander T Cohen Bruce L Davidson Alexander S Gallus Michael R Lassen Martin H Prins Witold Tomkowski Alexander G G Turpie Jan F M Egberts Anthonie W A Lensing 石汉平(译) 王深明(校) | 2006 | 英国医学杂志中文版2006，9，5： | 3 |
| 4 | Procalcitonin as a diagnostic test for sepsis in critically ill adults and after surgery or trauma: A systematic review and meta-analysis显示文摘 | Bernard Uzzan Régis Cohen Patrick Nicolas Michel Cucherat Gérard-Yves Perret | 2006 | Critical Care Medicine2006，，7： | 2 |
| 5 | Transmembrane ammonium sulfate gradients in liposomes produce efficient and stable entrapment of amphipathic weak bases显示文摘 | Haran G Cohen R BarL K | 1993 | Biochim Biophys Acta1993，1151，： | 2 |
| 6 | Treatment of urethral diseases with Neodymium- YAG laser显示文摘 | Bloiso G Warner R Cohen M | 1988 | J Uro11988，32，： | 2 |
| 7 | Nested monotony for variational inequalities over product ofspaces and convergence of iterative algorithms显示文摘 | Cohen G Chaplais F | 1988 | J Optim Theory Appl1988，59，2： | 2 |
| 8 | Vascular endothelial growth factor (VEGF) and its receptors显示文摘 | Neufeld G Cohen T Gengrinovitch S | 1999 | FASEB J1999，13，1： | 1 |
| 9 | Optical properties of granular silver and gold films显示文摘 | CODY G D COUTTS M D | 1973 | Phys Rev B1973，8，10： | 1 |
| 10 | Epidermic growth factor显示文摘 | Cohen S | 1990 | J Biol Chem1990，265，14： | 1 |
| 11 | Analytic relation between bulk moduli and lattice constants显示文摘 | Cohen M L Martinez G | 1987 | Phys Rev B1987，35，17： | 1 |
| 12 | of classifiers : theory, algorithms, and their application to human-computer interaction 显示文摘 | COHEN I COZMAN Semisupervised learning F G SEBE N etal | 2004 | IEEE Transactions on Pattern Analysis and Machine Intelligence2004，26，12： | 1 |
| 13 | Solar radiation changes in the united states during the twentieth century: Evidence from sunshine duration measurements显示文摘 | Stanhill G Cohen S | 2005 | Journal of Climate2005，18，： | 1 |
| 14 | Global dimming:A review of the evidence for a widespread and significant reduction in global radiation with discussion of its probable causes and possible agricultural consequences显示文摘 | Stanhill G Cohen S | 2001 | Agric Forest Meteorol2001，107，： | 1 |
| 15 | Optimization by decomposition and coordination: a unified approach显示文摘 | Cohen G | 1978 | IEEE Transactions on Automatic Control1978，23，： | 1 |
| 16 | Determinants of Release Rate of Tetanus Vaccine from Polyester Microspheres显示文摘 | ALONSO M J COHEN S PARK T G | 1993 | Pharm Res1993，10，： | 1 |
| 17 | Epidermal growth factor显示文摘 | Carpenter G Cohen S | 1979 | Annu Rev Biochem1979，48，1： | 1 |
| 18 | Diffusion in homicide:exploring a general method for detecting spatial diffusion process显示文摘 | COHEN J TITA G | 1999 | Journal of Quantitative Criminology1999，15，4： | 1 |
| 19 | Role of interferon-gamma in the evolution of murine bleomycin lung fibrosis显示文摘 | Segel M J Izbicki G Cohen P Y | 2003 | Am J Physiol Lung Cell Mol Physiol2003，285，11： | 1 |
| 20 | Vascular endothelial growth factor (VEGF) and its receptors 显示文摘 | Neufeld G Cohen T Gengrinovitch S | 1999 | FASEB J1999，13，1： | 1 |
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