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| 1 | Denosumab治疗绝经后妇女低骨密度显示文摘Background: Receptor activator of nuclear factor- κ B ligand (RANKL) is essential for osteoclast differentiation, activation, and survival. The fully human monoclonal antibody denosumab (formerly known as AMG 162)- binds RANKL with high affinity and specificity and inhibits RANKL action. Methods: The efficacy and safety of subcutaneously administered denosumab were evaluated over a period of 12 months in 412 postmenopausal women with low bone mineral density (T score of- 1.8 to - 4.0 at the lumbar spine or- 1.8 to- 3.5 at the proximal femur). Subjects were randomly assigned to receive denosumab either every three months (at a dose of 6, 14, or 30 mg) or every six months (at a dose of 14, 60, 100, or 210 mg), open- label oral alendronate once weekly (at a dose of 70 mg), or placebo. The primary end point was the percentage change from baseline in bone mineral density at the lumbar spine at 12 months. Changes in bone turnover were assessed by measurement of serum and urine telopeptides and bone-specific alkaline phosphatase. Results: Denosumab treatment for 12 months resulted in an increase in bone mineral density at the lumbar spine of 3.0 to 6.7 percent (as compared with an increase of 4.6 percent with alendronate and a loss of 0.8 percent with placebo), at the total hip of 1.9 to 3.6 percent (as compared with an increase of 2.1 percent with alendronate and a loss of 0.6 percent with placebo), and at the distal third of the radius of 0.4 to 1.3 percent (as compared with decreases of 0.5 percent with alendronate and 2.0 percent with placebo). Near-maximal reductions in mean levels of serum C- telopeptide from baseline were evident three days after the administration of denosumab. The duration of the suppression of bone turnover appeared to be dose-dependent. Conclusions: In postmenopausal women with low bone mass, denosumab increased bone mineral density and decreased bone resorption. These preliminary data suggest that denosumab might be an effective treatment for osteoporosis. | Mc Clung M.R. Michael Lewiecki E. Cohen S.B. 马超 | 2006 | 世界核心医学期刊文摘(妇产科学分册)2006，0，8： | 19 |
| 2 | Two types of astrocytes incultures of development rat white matter: differences in morphology, surface gangliosides and growth characteristics显示文摘 | Raff MC Abney ER Cohen J | 1983 | J Neurosci1983，3，： | 1 |
| 3 | The effect of low b-values on the intravoxel incoherent motionderived pseudodiffusion parameter in liver 显示文摘 | COHEN AD SCHIEKE MC HOHENWALTER MD | 2015 | Magn ResonMed2015，73，1： | 1 |
| 4 | Combination therapy with etanercept and anakinra in the treatment of patients with rheumatoid arthritis who have been treated unsuccessfully with methotrexate显示文摘 | Genovese MC Cohen S Moreland L | 2004 | Arthntis Rheum2004，50，5： | 1 |
| 5 | Effect of beta-blockade on circadian variation of ventricular arrhythmias显示文摘 | Cohen MC Rohtla KM Lavery EC | 1997 | Am J Cardiol1997，79，11： | 1 |
| 6 | Cytokine function: a study in biologic diversity显示文摘 | Cohen MC Cohen S | 1996 | Am J Clin Pathol1996，105，5： | 1 |
| 7 | Renal Cell carcinoma 显示文摘 | Cohen H Mc Govern F | 2005 | N Eng J Med En2005，353，： | 1 |
| 8 | Cytokine function :a study in biologic diversity显示文摘 | Cohen S | 1996 | Clin Pathol1996，105，5： | 1 |
| 9 | Cytokine function: a study in biologic diversity显示文摘 | Cohen MC Cohen S | 1996 | Am J Clin Pathol1996，105，5： | 1 |
| 10 | Complaints in forprofit,non-profit and public nursing homes in two Canadian provinces显示文摘 | Margaret J Mc Gregor Marcy Cohen Catherine-Rose | 2011 | Open Med2011，5，4： | 1 |
| 11 | Biliary lipids and cholesterol gallstone disease显示文摘 | Wang DQ Cohen DE Carey MC | 2009 | J Lipid Res2009，50，： | 1 |
| 12 | Meta - nalvsis of the morning excess of acute myocardial infarction and sudden cardiac death 显示文摘 | Cohen MC Rohtla KM Lavery CE | 1997 | Am J Cardiol1997，79，： | 1 |
| 13 | Strategies to enhance participant recruitment and retention in research involving acommunity-based population显示文摘 | McCullagh MC Sanon MA Cohen MA | 2014 | Applied Nursing Research2014，27，4： | 1 |
| 14 | Renal cell carcinoma显示文摘 | Cohen HT Mc Govern FJ | 2005 | N Engl J Med2005，353，23： | 1 |
| 15 | Metastatic pulmonary calcification with ossification in a child with acute lymphoblastic leukemia显示文摘 | Cohen MC Drut R | 1999 | Pediatr Pulmonol1999，27，2： | 1 |
| 16 | Continued inhibition of structural damage over 2 years in patients with rheumatoid arthritis treated with rituximab in combination with methotrexate显示文摘 | Cohen SB Keystone E Genovese MC | 2010 | Ann Rheum Dis2010，69，6： | 1 |
| 17 | Impact of diabetes on long-term survival after acute myocardial infarction:comparability of risk with prior myocardial infarction显示文摘 | Mukamal KJ Nesto RW Cohen MC | 2001 | Diabetes Care2001，24，8： | 1 |
| 18 | Interleukin - 10 rescues T cells from apoptotic cell death : association with upregulation of Bcl - 2 显示文摘 | Cohen SB Crawley JB Kahan MC | 1997 | Immunology1997，92，1： | 1 |
| 19 | Factors Affecting Patient Selection of Graft Type in Anterior Cruciate Ligament Reconstruction显示文摘 | Cohen SB Yucha DT Ciccotti MC | 2009 | The Journal of Arthroscopic&Related Surgery2009，25，9： | 1 |
| 20 | Pulmonary contusion:review of the clinical entity显示文摘 | Cohen MC | 1997 | J Trauma1997，12，7： | 1 |
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