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| 1 | Resective surgery for liver tumor: a multivariate analysis of causes and risk factors linked to postoperative complications显示文摘BACKGROUND: In spite of accurate selection of patients eligible for resection, and although advances in surgical techniques and perioperative management have greatly contributed to reducing the rate of perioperative deaths, stress must be placed on reducing the postoperative complication rates reported to be still as high as 50%. This study was designed to analyze the causes and foreseeable risk factors linked to postoperative morbidity on the grounds of data derived from a single-center surgical population. METHODS: From September 1989 to March 2005, 287 consecutive patients, affected either with HCC or liver metastasis, had liver resection at our department. Among the HCC series we recorded 98 patients (73.2%) in Child- Pugh class A, 32 (23.8%) in class B and 4 in class C (3%). In 104 colorectal metastases, 71% were due to colon cancer, 25% rectal, 3% sigmoid, and 1% anorectal. In 49 non-colorectal metastases, 22.4% were derived from breast cancer, 63.2% gastrointestinal tumors (excluding colon) and 14.4% other cancers. We performed 80 wedge resections, 77 bisegmentectomies and/or left lobectomies, 74 segmentectomies, 22 major hepatectomies, 20 left hepatectomies, and 14 trisegmentectomies. RESULTS: The in-hospital mortality rate in this series was 4.5%, and the morbidity rate was 47.7%, because of pleural effusion (30%), hepatic abscess (25%), hepatic insufficiency (19%), ascites (10%), hemoperitoneum (10%), or biliary fistula (6%). The variables associated with the technical aspects of the surgical procedure thatwere responsible for the complications were: a Pringle maneuver length more than 20 minutes (P=0.001); the type of liver resection procedure, including major hepatectomy (P=0.02), left hepatectomy (P=0.04), trisegmentectomy (P=0.04), bisegmentectomy and/or left lobectomy (P=0,04); and a blood transfusion of more than 600 ml (P=0.04). CONCLUSION: The evaluation of causes and foreseeable risk factors linked to postoperative morbidity during the planning of surgical treatment should play the same role as other factors weighed in the selection of patients eligible for liver resection. | Enrico Benzoni Dario Lorenzin Umberto Baccarani Gian Luigi Adani Alessandro Favero Alessandro Cojutti Fabrizio Bresadola Alessandro Uzzau | 2006 | Hepatobiliary & Pancreatic Diseases International2006，5，4： | 17 |
| 2 | Therapeutic drug monitoring may improve safety outcomes of long-term treatment with linezolid in adult patients显示文摘 | Pea F Viale P Cojutti P | 2012 | J Antimicrob Chemother2012，67，8： | 1 |
| 3 | Hydroforming of inhomogeneous sheet pairs with counterpressure显示文摘 | M. Geiger M. Merklein M. Cojutti | 2009 | Production Engineering2009，，1： | 1 |
| 4 | Hydroforming of inhomogeneous sheet pairs with counterpressure显示文摘 | M. Geiger M. Merklein M. Cojutti | 2009 | Production Engineering2009，，1： | 1 |
| 5 | Therapeutic drug monitoring may improve safety outcomes of long-term treatment with linezolid in adult patients显示文摘 | Pea F Viale P Cojutti P | 2012 | J AntimicrobChemother2012，67，8： | 1 |
| 6 | Liver resective surgery: a multivariate analysis of postoperative outcome and complication显示文摘 | Benzoni E Cojutti A Lorenzin D | 2007 | Langenbecks Arch Surg2007，392，1： | 1 |
| 7 | Integration of double sheet and tube hydroforming processes : Numerical investigation of the feasibility of a complex part显示文摘 | GEIGER M COJUTTI M | 2009 | International Journal of Computational Materials Science and Surface Engineering2009，2，12： | 1 |
| 8 | Liver resective surgery: a muhivariate analysis of postoperative outcome and complication 显示文摘 | Benzoni E Cojutti A Lorenzin D | 2007 | Langenbecks Arch Surg2007，392，1： | 1 |
| 9 | Therapeutic drug monitoring of linezolid: a retrospective monocentric analysis显示文摘 | Pea F Furlanut M Cojutti P | 2010 | Antimicrob Agents Chemother2010，54，11： | 1 |
| 10 | Therapeutic drug monitoring of linezolid:a retrospective monocentric analysis显示文摘 | Pea F Furlanut M Cojutti P | | 0，，11： | 1 |
| 11 | Laparoscopic versus open gastroplasty in esophagectomy for esophageal cancer: a com- parative study显示文摘 | Bresadola V Terrosu G Cojutti A | 2006 | Surg Laparosc Endosc Percut Tech2006，16，2： | 1 |
| 12 | Liver resective surgery:a multivariate analysis of postoperative outcome and complication显示文摘 | Benzoni E Cojutti A Lorenzin D | 2012 | Langenbecks Arch Surg2012，392，1： | 1 |
| 13 | Therapeutic drug mon- itoring of linezolid: a retrospective monocentric analysis 显示文摘 | Pea F Furlanut M Cojutti P | 2010 | Antimicrob Agents Chemother2010，54，11： | 1 |
| 14 | Liver resective surgery:a multivariate analysis of postoperative outcome and complication显示文摘 | Benzoni E Cojutti A Lorenzin D | | 0，，01： | 1 |
| 15 | Therapeutic drug moni- toring may improve safety outcomes of long-term treat- ment with linezolid in aduk patients显示文摘 | Pea F Viale P Cojutti P | 2012 | J Antirnicrob Chemother2012，67，8： | 1 |
| 16 | Therapeutic drug monitoring may improve safety outcomes of long-term treatment with linezolid in adult patients显示文摘 | Pea F Viale P Cojutti P | 2012 | Antimicrob Chemother2012，67，8： | 1 |
| 17 | Liver respect ivesurgery:amultivariate analysis of postoperative outcome and complication显示文摘 | Benzoni E Cojutti A Lorenzin D | 2007 | Langenbecks Arch Surg2007，392，1： | 1 |
| 18 | TDM-guided therapy withdaptomycin and meropenem in a morbidly obese, critically ill patient显示文摘 | Pea F Cojutti P Sbrojavacca R | 2011 | Ann Pharmacother2011，45，78： | 1 |
| 19 | Laparoscopic versus open gastroplasty in esophagectomy for esophageal cancer:a comparative study显示文摘 | Bresadola V Terrosu G Cojutti A | | 0，，2： | 1 |
| 20 | Laparoscopic versusopen gastroplasty in esophagectomy for esophageal cancer : a com-parative study显示文摘 | Bresadola V Terrosu G Cojutti A | 2006 | Surg Laparosc Endosc Percutan Tech2006，16，2： | 1 |
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