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| 1 | Dietary and metabolomic determinants of relapse in ulcerative colitis patients: A pilot prospective cohort study显示文摘AIM To identify demographic, clinical, metabolomic, and lifestyle related predictors of relapse in adult ulcerative colitis(UC) patients.METHODS In this prospective pilot study, UC patients in clinical remission were recruited and followed-up at 12 mo to assess a clinical relapse, or not. At baseline information on demographic and clinical parameters was collected. Serum and urine samples were collected for analysis of metabolomic assays using a combined direct infusion/liquid chromatography tandem mass spectrometry and nuclear magnetic resolution spectroscopy. Stool samples were also collected to measure fecal calprotectin(FCP). Dietary assessment was performed using a validated self-administered food frequency questionnaire. RESULTS Twenty patients were included(mean age: 42.7 ± 14.8 years, females: 55%). Seven patients(35%) experienced a clinical relapse during the follow-up period. While 6 patients(66.7%) with normal body weight developed a clinical relapse, 1 UC patient(9.1%) who was overweight/obese relapsed during the follow-up(P = 0.02). At baseline, poultry intake was significantly higher in patients who were still in remission during follow-up(0.9 oz vs 0.2 oz, P = 0.002). Five patients(71.4%) with FCP > 150 μg/g and 2 patients(15.4%) with normal FCP(≤ 150 μg/g) at baseline relapsed during the follow-up(P = 0.02). Interestingly, baseline urinary and serum metabolomic profiling of UC patients with or without clinical relapse within 12 mo showed a significant difference. The most important metabolites that were responsible for this discrimination were trans-aconitate, cystine and acetamide in urine, and 3-hydroxybutyrate, acetoacetate and acetone in serum. CONCLUSION A combination of baseline dietary intake, fecal calprotectin, and metabolomic factors are associated with risk of UC clinical relapse within 12 mo. | Ammar Hassanzadeh Keshtel iFloris F van den Brand Karen L Madsen Rupasri Mandal Rosica ValchevaKaren I Kroeker Beomsoo Han Rhonda C Bell Janis Cole Thomas Hoevers David S Wishart Richard N Fedorak Levinus A Dieleman | 2017 | World Journal of Gastroenterology2017，23，21： | 9 |
| 2 | Platelet-rich plasma for muscle injuries: A systematic review of the basic science literature显示文摘BACKGROUND Platelet-rich plasma(PRP) is an increasingly used biologic adjunct for muscle injuries, as it is thought to expedite healing. Despite its widespread use, little is known regarding the mechanisms by which PRP produces its efficacious effects in some patients.AIM To clarify the effects of PRP on muscular pathologies at the cellular and tissue levels by evaluating the basic science literature.METHODS A systematic review of PubMed/MEDLINE and EMBASE databases was performed using the Preferred Reporting Items for Systematic Reviews and MetaAnalyses(PRISMA) guidelines and checklist. Level III in vivo and in vitro studies examining PRP effects on muscles, myocytes and/or myoblasts were eligible for inclusion. Extracted data included PRP preparation methods and study results.RESULTS Twenty-three studies were included(15 in vivo, 6 in vitro, 2 in vitro/in vivo). Only one reported a complete PRP cytology(platelets, and red and white blood cell counts). Five in vitro studies reported increased cellular proliferation, four reported increased gene expression, and three reported increased cellular differentiation. Five in vivo studies reported increased gene expression, three reported superior muscle regeneration, and seven reported improved histological quality of muscular tissue.CONCLUSION The basic science literature on the use of PRP in muscle pathology demonstrates that PRP treatment confers several potentially beneficial effects on healing in comparison to controls. Future research is needed to determine optimal cytology,dosing, timing, and delivery methods of PRP for muscle pathologies. | Kyle N Kunze Charles P Hannon Jared D Fialkoff Rachel M Frank Brian J Cole | 2019 | World Journal of Orthopedics2019，10，7： | 6 |
| 3 | Soybean hull as a dietary fiber source for dogs显示文摘 | Cole J T Fahey G C Merchen N R | 1999 | J Anim Sci1999，77，： | 1 |
| 4 | Deciphering the biology of My cobacterium tuberculosis from the complete genome sequence 显示文摘 | Cole S T Brosch R Parkhill J Gamier T Churcher C Harris D Gordon S V Eiglmeier K Gas S Barry C E Tekaia F Badcock K Basham D Brown D Chillingworth T Cormor R Davies R Devlin K FeltweU T Gentles S Hamlin N Holroyd S Hornsby T Jagels K Kroghs A McLean J Moule S Murphy L Oliver K Osborne J Quail M A Rafandream M A Rogers J Rutter S Seeger K Skelton J Squaraes R Squares S Sulston J E Taylo K Whitehead S Barrell B G | 1998 | Nature1998，393，： | 1 |
| 5 | Carbon dioxidesupersaturation in the surface waters of lakes 显示文摘 | Cole J J Caraco F N Kling W G | 1994 | Science1994，265，5178： | 1 |
| 6 | Mapping resis- tanee quantitative trait Loci for three foliar diseases in a maize re- combinant inbred line population-evidence for multiple disease re- sistance显示文摘 | Zwonitzer J C Coles N D Krakowsky M D | 2010 | Phytopathology2010，100，1： | 1 |
| 7 | Review:Ammonia emissions from dairy farms and beef feedlots显示文摘 | Hristov A N Hanigan M Cole A | 2011 | Canadian Journal of Animal Science2011，，91： | 1 |
| 8 | Influence of buffers on pesticide and nutrient runoff from bermudagrass turf显示文摘 | Cole J H Baird J H Basta N T | 1997 | Journal of Environmental Quality1997，26，： | 1 |
| 9 | Buoyancy and drug release patterns of floating minitablets containing piretanide and atenolol as model drugs显示文摘 | Rouge N Cole ET Buri P | 1998 | Pharm Dev echnol1998，3，1： | 1 |
| 10 | Carbon dioxide concentration and atmospheric flux in the Hudson River 显示文摘 | Raymond P A Caraco N F Cole J J | 1997 | Estuaries1997，20，2： | 1 |
| 11 | Evaluation of synergistic ac- tivity of bovine lactoferricin with antibiotics in corneal infection 显示文摘 | Oo TZ Cole N Garthwaite L | 2010 | J Antimicrob Chemother2010，65，6： | 1 |
| 12 | Factors influencing bacterial adhesion to contact lenses显示文摘 | Dutta D Cole N Willcox M | 2012 | Mol Vis2012，，18： | 1 |
| 13 | The ING gene family in the regulation of cell growth and tumorigenesis 显示文摘 | COLES A H JONES S N | 2009 | J Cell Physiol2009，218，1： | 1 |
| 14 | Direct brazing of ceramics, graphite and refractory metals显示文摘 | CANONICO D A COLE N C SLAUGHTER G M | 1977 | Welding Journal1977，，8： | 1 |
| 15 | Thiazolidinedi one treatment normalizes insulin resistance and ischemic injury in the Zucker fatty rat heart显示文摘 | Sidell R J Cole MA Draper N J | 2002 | Diabetes2002，51，4： | 1 |
| 16 | Foraminifera and Ostracoda from Quaternary carbonate mounds associated with gas seepage in the Porcupine Basin, offshore Western Ireland显示文摘 | Coles G P Ainsworth N R Whatley R C | 1996 | Revista Espartola de Micropalentologia1996，28，： | 1 |
| 17 | Neonatal factors predicting childhood height in preterm infants:evidence for a persisting effect of early metabolic bone disease? 显示文摘 | Fewtrell M Cole TJ Bishop N J | 2000 | Pediatr2000，137，： | 1 |
| 18 | Time-dependent complexation of cysteine-capped gold nanoparticles with octadecylamine Langmuir monolayers at the air-water interface显示文摘 | Mayya K M Cole A Jain N | 2003 | Langmuir2003，19，： | 1 |
| 19 | Carbon-dioxide su- persaturation in the surface waters of lakes 显示文摘 | Cole J J Caraco N F Kling G W | 1994 | Science1994，265，： | 1 |
| 20 | Predicting diatom communities at the genus level for therapid bioligical assessment of rivers显示文摘 | Chessman B Growns I Currey J Plunkett Cole N | 1999 | Freshwater Biology1999，41，2： | 1 |
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