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| 1 | Dietary and metabolomic determinants of relapse in ulcerative colitis patients: A pilot prospective cohort study显示文摘AIM To identify demographic, clinical, metabolomic, and lifestyle related predictors of relapse in adult ulcerative colitis(UC) patients.METHODS In this prospective pilot study, UC patients in clinical remission were recruited and followed-up at 12 mo to assess a clinical relapse, or not. At baseline information on demographic and clinical parameters was collected. Serum and urine samples were collected for analysis of metabolomic assays using a combined direct infusion/liquid chromatography tandem mass spectrometry and nuclear magnetic resolution spectroscopy. Stool samples were also collected to measure fecal calprotectin(FCP). Dietary assessment was performed using a validated self-administered food frequency questionnaire. RESULTS Twenty patients were included(mean age: 42.7 ± 14.8 years, females: 55%). Seven patients(35%) experienced a clinical relapse during the follow-up period. While 6 patients(66.7%) with normal body weight developed a clinical relapse, 1 UC patient(9.1%) who was overweight/obese relapsed during the follow-up(P = 0.02). At baseline, poultry intake was significantly higher in patients who were still in remission during follow-up(0.9 oz vs 0.2 oz, P = 0.002). Five patients(71.4%) with FCP > 150 μg/g and 2 patients(15.4%) with normal FCP(≤ 150 μg/g) at baseline relapsed during the follow-up(P = 0.02). Interestingly, baseline urinary and serum metabolomic profiling of UC patients with or without clinical relapse within 12 mo showed a significant difference. The most important metabolites that were responsible for this discrimination were trans-aconitate, cystine and acetamide in urine, and 3-hydroxybutyrate, acetoacetate and acetone in serum. CONCLUSION A combination of baseline dietary intake, fecal calprotectin, and metabolomic factors are associated with risk of UC clinical relapse within 12 mo. | Ammar Hassanzadeh Keshtel iFloris F van den Brand Karen L Madsen Rupasri Mandal Rosica ValchevaKaren I Kroeker Beomsoo Han Rhonda C Bell Janis Cole Thomas Hoevers David S Wishart Richard N Fedorak Levinus A Dieleman | 2017 | World Journal of Gastroenterology2017，23，21： | 9 |
| 2 | 鼻阻力测压与鼻声反射测量的相关性研究显示文摘目的探讨主动后鼻阻力测压仪的参数——鼻阻力(nasal resistance,NR)与鼻声反射测量仪的参数——鼻腔容积(nasal cavity volume,NV)、鼻腔最小横截面积(minimal cross sectional area,MCSA)间是否具有相关性。方法应用主动后鼻阻力测压法和鼻声反射测量法对316例有鼻阻塞的患者进行前瞻性研究。根据减充血前双侧鼻阻力(bilateral NR,BNR)将患者分为2组,组1:BNR减充血前≤0.25 Pa/cm^3·s,组2:BNR减充血前>0.25 Pa/cm^3·s。Spearman等级相关分析研究上述两种客观测量法的参数在全体研究对象及各组中的相关性。结果在使用减充血剂前、后,316例患者单侧鼻阻力(unilateral NR,UNR)与单侧鼻腔容积(unilateral NV,UNV)、单侧鼻腔最小横截面积(unilateral MCSA,UMCSA)间均存在显著性负相关(P值均=0.000);组1(104例)和组2(212例)在减充血前、后的UNR与UNV、UMCSA间均存在显著性负相关(P值均=0.000)。鼻阻力与鼻腔最小横截面积的相关系数均大于鼻阻力与鼻气道容积的相关系数。结论在有鼻阻塞的患者中,NR、NV及MCSA存在负相关,MCSA是影响NR的主要因素。 | 张革化 李源 Ronald S Fenton Philip Cole Richard Rival Philip Solomon | 2008 | 中国耳鼻咽喉头颈外科2008，15，10： | 8 |
| 3 | Clearance of vancomycin during high-volume heamofiltration: impact of pre-dilution 显示文摘 | Uchino S Cole L Morimatsu H | 2002 | Intensive Care Med2002，，28： | 2 |
| 4 | Observations of the RT instability in laser imploded microballoons显示文摘 | Wark J S Kilkeany J D Cole A J | 1986 | Appl Phys Lett1986，48，15： | 2 |
| 5 | Response of dairy cows to high doses of a sustained- release bovine somatotropin administered during two lactations显示文摘 | EPARD P J HUDSON S COLE W J | 1991 | J Dairy Sci1991，74，： | 2 |
| 6 | Deciphering the biology of Mycobacteriurn tuberculosis from the complete genome sequence 显示文摘 | Cole S T Broseh R Parkhill J | 1998 | Nature1998，393，： | 1 |
| 7 | Molecular genetics and pathogenesis of Clostridium perfringens 显示文摘 | COLE S T | 1991 | Microbiol Rev1991，55，： | 1 |
| 8 | The role of actigraphy in the study of sleep and circadian rhythms显示文摘 | Cole R Alessi C | 2003 | Sleep2003，26，3： | 1 |
| 9 | Deciphering the biology of Mycobacterium tuberculosis from the complete genome sequence显示文摘 | Cole S T Brosch R Parkhill J | 1998 | Nature1998，393，6685： | 1 |
| 10 | Estimation of available phosphorus in soils by extraction with sodium bicarbonate 显示文摘 | Olsen S R Cole C V Watanabe F S | 1954 | USDA Circ1954，939，： | 1 |
| 11 | Risk factors and outcomes in patients with coronary artery aneurysms显示文摘 | BAMAN T S COLE J H DEVIREDDY C M | 2004 | Am J Cardiol2004，93，12： | 1 |
| 12 | Bacterial production in fresh and saltwater ecosystems : a cross - system overview显示文摘 | Cole J J Findlay S Pace M L | 1988 | Mar Ecol Prog Set1988，43，： | 1 |
| 13 | Double intussusception fatally complicated by clostridial infection in a dog(a case report) 显示文摘 | Okewole P A Odeyemi P S Cole T | 1989 | Br Vet J1989，145，3： | 1 |
| 14 | Inflammation and Alzheimer's disease显示文摘 | Akiyama H Barger S Barnum S Bradt B Bauer J Cole GM | 2000 | Neurobiol Aging2000，21，3： | 1 |
| 15 | Deciphering the biology of My cobacterium tuberculosis from the complete genome sequence 显示文摘 | Cole S T Brosch R Parkhill J Gamier T Churcher C Harris D Gordon S V Eiglmeier K Gas S Barry C E Tekaia F Badcock K Basham D Brown D Chillingworth T Cormor R Davies R Devlin K FeltweU T Gentles S Hamlin N Holroyd S Hornsby T Jagels K Kroghs A McLean J Moule S Murphy L Oliver K Osborne J Quail M A Rafandream M A Rogers J Rutter S Seeger K Skelton J Squaraes R Squares S Sulston J E Taylo K Whitehead S Barrell B G | 1998 | Nature1998，393，： | 1 |
| 16 | Intracellular P-gp contributes to functional drug efflux and resistance in acute myeloid leukaemia 显示文摘 | Ferrao P Sincock P Cole S | 2001 | Leuk Res2001，25，5： | 1 |
| 17 | Inflammation and Alzheimer' s disease 显示文摘 | Akiyama H Barger S Barnum S Bradt B Bauer J Cole GM et a/ | 2000 | Neurobiol Ag- ing2000，21，3： | 1 |
| 18 | Breeding and genetics symposium: really big data: processing and analysis of very large data sets 显示文摘 | Cole J B Newman S Foertter F | 2012 | Journal of Animal Sciences2012，90，3： | 1 |
| 19 | Idealized steering for hauling locomotives 显示文摘 | Simson S A Cole C | 2010 | Journal of Rail and Rapid Transit2010，224，： | 1 |
| 20 | An Integer-programming-based Approach to the Close-Enough Traveling Salesman Problem显示文摘 | BEHDANI B COLE S J | 2014 | Informs Journal on Computing2014，26，3： | 1 |
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