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| 1 | Evaluation of biodegradable electric conductive tube-guides and mesenchymal stem cells显示文摘AIM: To study the therapeutic effect of three tubeguides with electrical conductivity associated to mesenchymal stem cells(MSCs) on neuro-muscular regeneration after neurotmesis.METHODS: Rats with 10-mm gap nerve injury were tested using polyvinyl alcohol(PVA), PVA-carbon nanotubes(CNTs) and MSCs, and PVA-polypyrrole(PPy). The regenerated nerves and tibialis anterior muscles were processed for stereological studies after 20 wk. The functional recovery was assessed serially for gait biomechanical analysis, by extensor postural thrust, sciatic functional index and static sciatic functionalindex(SSI), and by withdrawal reflex latency(WRL). In vitro studies included cytocompatibility, flow cytometry, reverse transcriptase polymerase chain reaction and karyotype analysis of the MSCs. Histopathology of lung, liver, kidneys, and regional lymph nodes ensured the biomaterials biocompatibility. RESULTS: SSI remained negative throughout and independently from treatment. Differences between treted groups in the severity of changes in WRL existed, showing a faster regeneration for PVA-CNTs-MSCs(P < 0.05). At toe-off, less acute ankle joint angles were seen for PVA-CNTs-MSCs group(P = 0.051) suggesting improved ankle muscles function during the push off phase of the gait cycle. In PVA-PPy and PVA-CNTs groups, there was a 25% and 42% increase of average fiber area and a 13% and 21% increase of the 'minimal Feret's diameter' respectively. Stereological analysis disclosed a significantly(P < 0.05) increased myelin thickness(M), ratio myelin thickness/axon diameter(M/d) and ratio axon diameter/fiber diameter(d/D; g-ratio) in PVA-CNT-MSCs group(P < 0.05). CONCLUSION: Results revealed that treatment with MSCs and PVA-CNTs tube-guides induced better nerve fiber regeneration. Functional and kinematics analysis revealed positive synergistic effects brought by MSCs and PVA-CNTs. The PVA-CNTs and PVA-PPy are promising scaffolds with electric conductive properties, bio- and cytocompatible that might prevent the secondary neurogenic muscular atrophy by improving the reestablishment of the neuro-muscular junction. | Jorge Ribeiro Tiago Pereira Ana Rita Caseiro Paulo Armada-da-Silva Isabel Pires Justina Prada Irina Amorim Sandra Amado Miguel Franca Carolina Goncalves Maria Ascensao Lopes Jose Domingos Santos Dina Morais Silva Stefano Geuna Ana Lúcia Luís Ana Colette Maurício | 2015 | World Journal of Stem Cells2015，7，6： | 2 |
| 2 | Effects of dietary alpha linolenic acid on cholesterol metabolism in male and female hamsters of the LPN strain显示文摘 | ANNE M COLETTE S DANIEL G | 2004 | J Nutr Biochem2004，15，： | 1 |
| 3 | Absence of aromatase protein and mRNA expression in endometriosis 显示文摘 | Colette S Lousse JC Defrere S | 2009 | Hum Reprod2009，24，9： | 1 |
| 4 | Review:iuminesccncc as a toolto assess pelvic endometriosis evelopment in murine models 显示文摘 | Defrere S Colette S Lousse JC | 2009 | Reprod Sci2009，16，12： | 1 |
| 5 | Enteral absorption inman of eicosapentaenoic acid in different chemical forms显示文摘 | BOUSTANI S E COLETTE C MONNIER L | 1987 | Lipids1987，22，： | 1 |
| 6 | Molecular cloning and nucleotide sequence of the pestivirus bovine viral diarrhea virus显示文摘 | Colett M S Larson R Gold C | 1988 | Virology1988，165，1： | 1 |
| 7 | Magnitude of the dawn phenomenon and its impact on the overall glucose exposure in type 2 diabetes: is this of concern?显示文摘 | Monnier L Colette C Dejager S | 2013 | Diabetes Care2013，36，12： | 1 |
| 8 | Guiding Goal Modeling Using Scenarios 显示文摘 | Colette R Carine S | 1998 | IEEE Transaction on Software Engineering1998，24，12： | 1 |
| 9 | Magnitude of the dawn phenomenon and its impact on the overall glucose exposure in type 2 diabetes : is this of concern 显示文摘 | Monnier L Colette C Dejager S | 2013 | Diabetes Care2013，36，12： | 1 |
| 10 | Endometriosis显示文摘 | Colette S Donnez J | 2009 | N Engl J Med2009，360，18： | 1 |
| 11 | Magnitude of the dawn phenomenon and its impact on the overall glucose exposure in type 2 diabetes:is this of concern显示文摘 | Monnier L Colette C Dejager S | 2013 | Dia-betes Care2013，36，12： | 1 |
| 12 | Magnitude of the dawn phenomenon and its impact on the overall glucose exposure in type 2 diabetes:is this of concern? 显示文摘 | Monnier L Colette C Dejager S | 2013 | Dia- betes Care2013，36，12： | 1 |
| 13 | Probioties: mechanisms and established effects 显示文摘 | Arthur C O Pirkka V K Colette S | 1999 | International Dairy Journal1999，9，： | 1 |
| 14 | Enteral absorption in man of eicosapentaenoic acid in different chemical forms显示文摘 | Elboustani S Colette C Monnier L | 1987 | Lipids1987，22，10： | 1 |
| 15 | Probiotics: mechanisms and established effects 显示文摘 | Arthur C O Pirkka V K Colette S | 1999 | Int Dairy J1999，9，： | 1 |
| 16 | Control of apoptosis during angiogenesis by survivin expression in endothelial cells显示文摘 | Daniel S O Jeffrey S S Colette A el al | 2000 | Am J Pathol2000，156，2： | 1 |
| 17 | Magnitude of the dawn phenomenon and its impact on the overall glucose expo- sure in type 2 diabetes:is this of concern?显示文摘 | MONNIER L COLETTE C DEJAGER S | 2013 | Diabetes Care2013，36，12： | 1 |
| 18 | Absence of aromatase proteinand mRNA expression in endometriosis显示文摘 | Colette S Lousse JC Defrère S | 2009 | Hum Reprod2009，24，9： | 1 |
| 19 | Use of elec trospray mass spectrometry (ESIMS) for the study of europium(Ⅲ) complexation with bis(dialkyltriaz inyl) pyridines and its implications in the design of new extracting agents显示文摘 | Colette S Amekraz B Madic C | 2002 | Inorg Chem2002，41，： | 1 |
| 20 | Effects of dietary alpha linolenic acid on cholesterol metabolism in male and female hamsters of the LPN strain 显示文摘 | Anne M Colette S R Daniel G | 2004 | Journal of Nutritional Biochemistry2004，，15： | 1 |
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