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| 1 | Hepatic steatosis in overweight/obese females: New screening method for those at risk显示文摘AIM: To identify which parameters could help to distinguish the 'metabolically benign obesity', which is not accompanied by insulin resistance (IR) and early atherosclerosis.METHODS: Eighty two of 124 overweight/obese females formed the study population, which was divided into two groups (52 and 30 subjects, respectively) with and without IR according to a HO meostatic Metabolic Assessment (HOMA) cut-off of 2, and were studied in a cross-sectional manner. The main outcome measures were waist circumference, serum uric acid, high-density lipoprotein-cholesterol and triglycerides, alanine amino-transferase, blood pressure and the two imaging para-meters, hepatic steatosis and longitudinal diameter of the spleen, which were measured in relation to the presence/absence of IR. RESULTS: A variable grade of visceral obesity was observed in all subjects with the exception of three.Obesity of a severe grade was represented more in the group of IR individuals (P = 0.01). Hepatic steatosis, revealed at ultrasound, was more pronounced in IR than in non-IR subjects (P = 0.005). The two groups also demonstrated a clear difference in longitudinal spleen diameter and blood pressure, with raised and signif icant values in the IR group. Metabolic syndrome was frequent in the IR group, and was not modified when adjusted for menopause (P = 0.001). At linear regression, the β values of waist circumference and body mass index predicting HOMA were 0.295, P = 0.007 and 0.41, P = 0.0001, respectively. Measures of spleen longitudinal diameter were well predicted by body mass index (BMI) values, β = 0.35, P = 0.01, and by HOMA, β = 0.41, P = 0.0001. Blood pressure was predicted by HOMA values, β = 0.39, P = 0.0001). HOMA and hepatic steatosis were highly associated (rho = 0.34, P = 0.002). Interestingly, IR patients were almost twice as likely to have hepatic steatosis as non-IR patients. Among the MS criteria, blood pressure was very accurate in identifying the presence of IR (AUROC for systolic blood pressure 0.66, cut-off 125 mm of Hg, sensibility 64%, specif icity 75%; AUROC for diastolic blood pressure 0.70, cut-off 85 mm of Hg, sensibility 54.5%, specif icity 75%). CONCLUSION: As health care costs are skyrocketing, reliable and mainly inexpensive tools are advisable to better defi ne subjects who really need to lose weight. | Giovanni Tarantino Genoveffa Pizza Annamaria Colao Fabrizio Pasanisi Paolo Conca Patrizia Colicchio Carmine Finelli Franco Contaldo Carolina Di Somma Silvia Savastano | 2009 | World Journal of Gastroenterology2009，15，45： | 4 |
| 2 | Factors of surgical outcome in tumoral epilepsy 显示文摘 | Rossi GF Pompucci A Colicchio G | 1999 | Acta Neurochir (Wien)1999，141，8： | 1 |
| 3 | CXCR4-CXCL12-dependent inflammatory network and endothelial progenitors显示文摘 | SALVATORE P PAGLIARULO C COLICCHIO R et-al | 2010 | Curr Med Chem2010，17，27： | 1 |
| 4 | Non alcoholic fatty liver disease in young adult severely obese non - diabetic patients in South Italy 显示文摘 | Colicchio P Tarantino G del Genio F | 2005 | Ann Nutr Metab2005，49，： | 1 |
| 5 | Young adult obese subjects with and without insulin resistance:what is the role of chronic inflammation and how to weigh it non-invasively显示文摘 | Tarantino G Colicchio P Conca P | | Journal of Inflammation (London England)0，，： | 1 |
| 6 | Heart rate and heart rate variability modification in chronic insomnia pa- tients显示文摘 | Farina B Dittoni S Colicchio SA | 2014 | Behav Sleep Med2014，12，4： | 1 |
| 7 | Zernike polynomial applications in 3-D fluorescence microscopy显示文摘 | Nicolas Hueber Bruno Colicchio Alain Dieterlen | 2003 | Joumee du CRESPIM2003，，1： | 1 |
| 8 | Heart rate and heart rate variability modification in chronic insomnia patients 显示文摘 | FARINA B DITrONI S COLICCHIO S A | 2014 | Behav Sleep Med2014，12，4： | 1 |
| 9 | Heart rate and heart rate variability modification in chronic insomnia patients 显示文摘 | FARINA B DITYONI S COLICCHIO S A | 2014 | Behav Sleep Med2014，12，4： | 1 |
| 10 | Heart rate and heart rate variability modification in chronic insomnia patients显示文摘 | Farina B Dittoni S Colicchio SA | 2014 | Behav Sleep Med2014，12，4： | 1 |
| 11 | Serum and Intestinal Celiac Disease–associated Antibodies in Children With Celiac Disease Younger Than 2 Years of Age显示文摘 | Mariantonia Maglio Antonella Tosco Francesco Paparo Renata Auricchio Viviana Granata Barbara Colicchio Viviana Indolfi Erasmo Miele Riccardo Troncone | 2010 | Journal of Pediatric Gastroenterology and Nutrition2010，，1： | 1 |
| 12 | A domain-decomposition strategy for a compressible multi-phase flow interacting with a structure显示文摘 | Greco M Colicchio G Fahinsen O M | 2014 | International Journal for Numerical Methods in Engineering2014，98，： | 1 |
| 13 | Effect of a Weak Electrolyte on the Critical Micellar Concentration of Sodium Dodecyl Sulfate显示文摘 | Esposito E Colicchio P Facchiano A | 1998 | J Colloid Interf Sci1998，200，： | 1 |
| 14 | Telomere Shortening: a New Prognostic Factor for Cardivascular Dis- ease Post-radiation Exposure显示文摘 | M' kacher R Girinsky T Colicchio B | 2015 | Radiation Protection Do- simetry2015，164，12： | 1 |
| 15 | Vagal nerve stimu- lation for drug-resistant epilepsies in different age, aetiology and duration显示文摘 | Colicchio G Policicchio D Barbati G | 2010 | Childs Nerv Syst2010，26，6： | 1 |
| 16 | Factors of surgical outcome in tumoural epilepsy 显示文摘 | ROSSI G F POMPUCCI A COLICCHIO G | 1999 | Acta Neurochir (Wien)1999，141，8： | 1 |
| 17 | Geniculate ganglion meningioma显示文摘 | Magliulo G Alla FR Colicchio G | 2010 | Skull Base2010，20，3： | 1 |
| 18 | Enlarged internal audi- tory canal and Sudden deafness显示文摘 | Magliulo G Stasolla A Colicchio MG | 2010 | J Laryngol Otol2010，124，8： | 1 |
| 19 | Callosotomy for severe epilepsies with generalized seizure: outcome and prognostic factors 显示文摘 | Rossi GF Colicchio G Marchese | 1996 | Acta Neurochir (Wien)1996，138，： | 1 |
| 20 | Influence of the silica content in SPEEK-silica membranes prepared from the sol- gel process of polyethoxysiloxane: morphology and proton mobility 显示文摘 | Colicchio I Demco D E Baias M | 2009 | Journal of Membrane Science2009，337，1： | 1 |
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