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| 1 | Novel susceptibility genes in inflammatory bowel disease显示文摘The inflammatory bowel disease, Crohn's disease and ulcerative colitis, are polygenic disorders with important environmental interactions. To date, the most widely adopted approach to identifying susceptibility genes in complex diseases has involved genome wide linkage studies followed by studies of positional candidate genes in loci of interest. This review encompasses data from studies into novel candidate genes implicated in the pathogenesis of inflammatory bowel disease. Novel techniques to identify candidate genes-genome wide association studies, yeast-two hybrid screening, microarray gene expression studies and proteomic profiling, are also reviewed and their potential role in unravelling the pathogenesis of inflammatory bowel disease are discussed. | Colin Noble Elaine Nimmo Daniel Gaya Richard K Russell Jack Satsangi | 2006 | World Journal of Gastroenterology2006，12，13： | 3 |
| 2 | A statistical explanation of MaxEnt for ecologists显示文摘 | JaneElith Steven J.Phillips TrevorHastie MiroslavDudík Yung EnChee Colin J.Yates | 2010 | Diversity and Distributions2010，，1： | 2 |
| 3 | PI_3激酶参与AT_1受体介导Ang II调节SHR脑神经元电活动的信号转导显示文摘目的 探索AT1受体介导AngII调节SHR和WKY鼠脑神经元电活动的信号转导机制。 方法 原代培养SHR和WKY新生鼠脑干和下丘脑神经元 ,用全细胞膜片钳以电流箝方式记录神经元的放电活动 ,观察AngII及各种信号分子抑制剂对脑神经元放电频率的影响。结果 AngⅡ (10 0nmol·L-1)可使WKY新生鼠脑神经元的放电频率从 (0 .4 4± 0 .0 8)Hz增加到 (1.39± 0 .16 )Hz。这种效应在SHR鼠更加显著。由AngⅡ引起的这两种鼠脑神经元放电频率的增加均可被AT1受体拮抗剂Losartan完全消除。使用PKC抑制剂calphostinC和钙调蛋白激酶II抑制剂KN 93能完全阻断AngⅡ对WKY鼠脑神经元的作用 ,但对SHR鼠脑神经元的放电频率仅阻抑约 5 0 %。磷脂酰肌醇 3(PI3 )激酶抑制剂LY2 94 0 0 2 (10 μmol·L-1)对SHR鼠脑神经元的放电频率可产生部分阻断作用 ,但对WKY鼠脑神经元无明显影响。结论 AngII增加SHR和WKY鼠脑神经元放电频率的作用均由AT1受体介导。PI3 | 杜剑青 孙成文 唐敬师 Colin Sumners Mohan K Raizada | 2003 | 西安交通大学学报(医学版)2003，24，6： | 2 |
| 4 | Orthodontic tooth movement in the prednisolone-Treated rat显示文摘 | Colin K Laurence J Douglas H | 2000 | Angle Orthod2000，70，： | 1 |
| 5 | Biomechanical and morphological corneal response to placement of intrastromal corneal ring segments for keratoconus显示文摘 | Caroline Dauwe David Touboul Cynthia J. Roberts Ashraf M. Mahmoud Julien Kérautret Pierre Fournier Fran?ois Malecaze Joseph Colin | 2009 | Journal of Cataract & Refractive Surgery2009，，10： | 1 |
| 6 | Vertical distributions of lightning NO, for use in regional and global chemical transport models 显示文摘 | Pickering K E Wang Yansen Too Wei-kuo Price Colin Muller J-F | 1998 | J Geophys Res1998，103，31： | 1 |
| 7 | Cmeias color segmentation= an improved computing technology to process color images for quantitative microbial ecology studies at single cell res olution显示文摘 | Gross Colin A Reddy Chandan K Dazzo Frank B | 2010 | Microbial Ecology2010，59，40： | 1 |
| 8 | Impact of cattle on soil physical properties and nutrient concentrations in overland flow from pasture in Ireland显示文摘 | Isabelle K Colin D R Hubert T | 2006 | Agriculture Ecosystems and Environment2006，113，： | 1 |
| 9 | Cellular and molecular mechanisms of glial scarring and progressive cavitation: in vivo and in vitro analysis of inflammationinduced secondary injury after CNS trauma 显示文摘 | Michael TF Catherine D Colin K | 1999 | J Neurosci1999，19，19： | 1 |
| 10 | Pharmacological character- isation of oxytocin binding sites in the ovine pineal gland 显示文摘 | Hamid R R David K M Colin D I | 1997 | Regulatory Peptides1997，70，： | 1 |
| 11 | Characterization of polyploid wheat genomic diversity using a high-density 90 000 single nucleotide polymorphism array 显示文摘 | Wang SC Debbie W Kerrie F Alexandra A Shiaoman C Bevan EH Marco M Silvio S Sara GM Luigi C Anna MM Alex W Stuart S Gary B Ralf W Joerg P International Wheat Genome Sequencing Consortium Morten L Diane M Rudi A Rudy D Gina BG Abraham K Alina RA Catherine F Jerome S Michele M Curtis P Luo MC Jan DMM Jorge D Martin G Roberto T Cindy L Ivan M Colin C Keith JE Matthew H Eduard A | 2014 | Plant Biotechnol J2014，12，： | 1 |
| 12 | Corneal penetration of levofloxaein into the human aqueous humour: a comparison with eiprofloxaein 显示文摘 | Colin J Simonpoli S Geldsetzer K | 2003 | Acta Ophthalmologiea Seandinavica2003，81，6： | 1 |
| 13 | Determination of 3 - chloro - 1,2 - propanediol in foods and food ingredients by gas chromatography with mass spectrometric detection:collaborative study 显示文摘 | Paul B janet K Colin C | 2001 | Journal of AOAC International2001，84，2： | 1 |
| 14 | Functional dyspepsia:A classification with guidelines for diagnosis and management显示文摘 | Colin Jone D Koch K L | 1991 | Gastroenterol Int1991，，4： | 1 |
| 15 | A Learning-Based Model of Repeated Games with Incomplete Information显示文摘 | CHONG J K COLIN F | 2006 | Games and Eco-nomic Behavior2006，55，2： | 1 |
| 16 | Extraction of organic compounds with room temperature ionic liquids 显示文摘 | Poole Colin F Poole Salwa K | 2010 | Journal of Chromatography A2010，1217，16： | 1 |
| 17 | Effects of chain length and heat treatment on the nauotribology of alkylsilanemonolayers self-assembled on a rough aluminum surface 显示文摘 | Khatri O P Colin D B Sanjay K B | 2005 | J Phys Chem B2005，109，23： | 1 |
| 18 | Combination therapy for dendritic keratitis with human leukocyte interferon and acyclovir显示文摘 | Colin J Chastel C Renard G Cantell K | 1983 | Am J Ophthalmol1983，95，： | 1 |
| 19 | Beta-amyloid stimulation of microglial and monocytes results in TNFα-dependent expression of inducible nitric oxide synthase and neuronal apoptosis 显示文摘 | Colin K Combs J Colleen K | 2001 | J Neurosci2001，21，4： | 1 |
| 20 | Coordinated multitissue transcriptional and plasma metabonomic profiles following acute caloric restriction in mice显示文摘 | COLIN S NICOLA D K ANISHA C | 2006 | Physiological Genomics2006，27，6： | 1 |
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