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| 1 | It is safe to use transdermal glyceryl trinitrate to lower blood pressure in patients with acute ischaemic stroke with carotid stenosis显示文摘Background There is concern that blood pressure(BP)lowering in acute stroke may compromise cerebral perfusion and worsen outcome in the presence of carotid stenosis.We assessed the effect of glyceryl trinitrate(GTN)in patients with carotid stenosis using data from the Efficacy of Nitric Oxide in Stroke(ENOS)Trial.Methods ENOS randomised 4011 patients with acute stroke and raised systolic BP(140-220 mm Hg)to transdermal GTN or no GTN within 48 hours of onset.Those on prestroke antihypertensives were also randomised to stop or continue their medication for 7 days.The primary outcome was the modified Rankin Scale(mRS)at day 90.Ipsilateral carotid stenosis was split:<30%;30-<50%;50-<70%;≥70%.Data are ORs with 95%CIs adjusted for baseline prognostic factors.results 2023(60.5%)ischaemic stroke participants had carotid imaging.As compared with<30%,≥70%ipsilateral stenosis was associated with an unfavourable shift in mRS(worse outcome)at 90 days(OR 1.88,95%CI 1.44 to 2.44,p<0.001).Those with≥70%stenosis who received GTN versus no GTN had a favourable shift in mRS(OR 0.56,95%CI 0.34 to 0.93,p=0.024).In those with 50-<70%stenosis,continuing versus stopping prestroke antihypertensives was associated with worse disability,mood,quality of life and cognition at 90 days.Clinical outcomes did not differ across bilateral stenosis groups.Conclusions Following ischaemic stroke,severe ipsilateral carotid stenosis is associated with worse functional outcome at 90 days.GTN appears safe in ipsilateral or bilateral carotid stenosis,and might improve outcome in severe ipsilateral carotid stenosis. | Jason P Appleton Lisa J Woodhouse Andrew Belcher Daniel Bereczki Eivind Berge Valeria Caso Hui Meng Chang Hanne K Christensen Ronan Collins John Gommans Ann C Laska George Ntaios Serefnur Ozturk Gillian M Sare Szabolcs Szatmari Yongjun Wang Joanna M Wardlaw Nikola Sprigg Philip M Bath for the ENOS investigators | 2019 | Stroke & Vascular Neurology2019，4，1： | 6 |
| 2 | 针对患者利益的机器学习和人工智能研究:在透明性、可重复性、伦理和有效性等方面的20个关键问题显示文摘机器学习(ML)、人工智能(AI)和其他现代统计方法正为利用先前尚未开发且极速增长的数据资源提供新的机会,以期让患者获益。尽管目前正在进行许多有前景的研究,特别是在图像方面,但就文献整体而言还缺乏透明度、对可重复性清晰的阐述、对潜在伦理问题的探究,以及对有效性的明确验证。这些问题的存在有许多原因,其中最重要的一点(为此我们提供了初步解决方案)就是当前缺乏针对ML和AI的最佳实践指南。我们认为从事研究的跨学科团队和应用ML/AI影响健康的项目,将因解决有关透明度、可重复性、伦理和有效性(TREE)的一系列问题而受益。这里提出的20个关键问题为研究团队提供了一个研究设计、实施和报告框架;帮助编辑和同行评审专家评估文献的贡献;让患者、临床医生和政策制定者评估新发现可能会给患者带来的获益。 | Sebastian Vollmer Bilal A Mateen Gergo Bohner Franz J Kirdly Rayid Ghani Pall Jonsson Sarah Cumbers Adrian Jonas Katherine S L McAllister Puja Myles David Granger Mark Birse Richard Branson Karel G M Moons Gary S Collins John P A Chris Holmes Harry Hemingwayp 李峰(译) 徐磊(校) 赵邑(校) | 2020 | 英国医学杂志中文版2020，23，9： | 5 |
| 3 | The modified compression-field theory for reinforced concrete elements subjected to shear 显示文摘 | Vecchio F J Collins M P | 1986 | ACI Structural Journal1986，83，2： | 2 |
| 4 | The modified compression field theory for reinforced concrete elements subjected to shear 显示文摘 | Vecchio F J Collins M P | 1986 | ACI Journal1986，83，2： | 1 |
| 5 | The modified compression-filed theory for reinforced concrete elements subjected to shear显示文摘 | Vecchio F J and Collins M P | | ACI Struct J0，83，2： | 1 |
| 6 | High incidence of micrometastasesin breast cancer sentinel nodes 显示文摘 | Mann B G Buchana M Collins P J | 2000 | Aust N ZJ Surg2000，70，： | 1 |
| 7 | Simplified modi- fied compression field theory for calculating shear strength of reinforced concrete elements 显示文摘 | Bentz E C Vecehio F J Collins M P | 2006 | ACI Structural Journal2006，103，4： | 1 |
| 8 | Colon cancer: a civilization disorder显示文摘 | Watson A J Collins P D | 2011 | Dig Dis2011，29，2： | 1 |
| 9 | Breach erosion of earthfill dams (BEED) model显示文摘 | SINGH V P SCARLATOS P D COLLINS J G | 1988 | Natural Hazards1988，1，2： | 1 |
| 10 | Dynamic response and vibration control of wind turbine towers 显示文摘 | Murtagh P J Collins R Basu B | 2004 | Irish Engineers Journal2004，58，7： | 1 |
| 11 | Predicting the response of reinforced concrete beams subjected to shear using modified compression field theory 显示文摘 | Vecchio F J Collins M P | 1988 | ACI Structural Journal1988，85，3： | 1 |
| 12 | Stabilization of lignin peroxidase in white rot fungi by tryptophan显示文摘 | Collins P J Field J A Teunissen P | 1997 | Applied and Environmen- tal Microbiology1997，63，7： | 1 |
| 13 | The modified compression-field theory for reinforced concrete elements subjected to shear显示文摘 | Vecchio F J Collins M P | 1986 | ACI1986，83，2： | 1 |
| 14 | The effect of young biochar on soil respiration显示文摘 | Smith J L Collins H P Bailey V L | 2010 | Soil Biology and Biochemistry2010，42，12： | 1 |
| 15 | Simulating aerosols using a chemical transport model with assimilation of satellite aerosol retrievals:Methodology for INIXIEX显示文摘 | Collins W D P J Rasch B E Eaton | 2001 | J Geophys Res2001，106，7： | 1 |
| 16 | Oxidation of anthracene and benzo pyrene by laccases from Trametes versicolor 显示文摘 | COLLINS P J KOTTERMAN M J J FIELD J A | 1996 | Appl Environ Microbiol1996，62，12： | 1 |
| 17 | Ecological aspects of amphibian metamorphosis显示文摘 | Wilbur H M Collins J P | 1973 | Science1973，182，4119： | 1 |
| 18 | The modified compression field theory for reinforced concreteelements subjected to shear显示文摘 | Vecchio F J Collins M P | 1986 | ACI Structural Journal1986，83，2： | 1 |
| 19 | The modified compression-field theory for reinforced concrete elements subjected to shear 显示文摘 | Vecchio F J Collins M P | 1986 | ACI Structural Journal1986，83，2： | 1 |
| 20 | Extension of the MIMO precoder based on the minimum Euclidean distance: a cross-form matrix 显示文摘 | VRIGNEAU B LETESSIER J ROSTAING P COLLIN L BUREL G | 2008 | IEEE Journal of elected Topics in Signal Processing2008，2，2： | 1 |
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