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| 1 | PrP^C-related signal transduction is influenced by copper, membrane integrity and the alpha cleavage site显示文摘铜绑定,抛锚膜的、细胞的 prion 蛋白质(PrPC ) 有二个组成的劈开地点生产不同 N 终端和 C 终端碎片(N1/C1 和 N2/C2 ) 。用表示也人的 PrPC,鼠标 PrPC 或鼠标 PrPC 的 RK13 房间带 3F4 epitope,这研究在 endoproteolytic 劈开和一个通常认为的 PrPC 函数上探索了 PrPC 主要顺序的影响,地图 kinase 信号 transduction,响应外长的铜与或没有使不安的膜环境。PrPC 主要顺序,特别在 N1/C1 劈开地点附近,看起来在这个地点和细胞外的调整信号的 kinase 1/2 (ERK1/2 ) phosphorylation 影响解朊作用的基础层次,与处理激活增加与基础 ERK1/2 表明一种反的关系。人的 PrPC 独自响应铜显示出增加的 N1/C1 劈开,由特定的 p38 和 JNK/SAPK phosphorylation 伴随了。到加扣押胆固醇的抗菌素 filipin 的铜的联合暴露导致了一只老鼠信号蛋白质 phosphorylation 的 PrPC 特定的实质的增加,由 N1/C1 劈开的增加伴随了。怀有人的 N1/C1 劈开地点的老鼠 PrPC 基础地并且响应铜假定更似人类的侧面并且改变了膜环境。我们的结果证明在 N1/C1 劈开地点附近的 PrPC 主要顺序影响在这个地点处理的 endoproteolytic,它显得连接了基础地并且响应铜印射 kinase 信号 transduction。进一步,主要顺序看起来响应外长的刺激在 PrPC 相关的信号 transduction 的忠实上授与 N1/C1 劈开和膜完整的相互的依赖。 | Cathryn L Haigh | 2009 | Cell Research2009，19，9： | 4 |
| 2 | Blood classical monocytes phenotype is not altered in primary non-small cell lung cancer显示文摘AIM: To evaluate the M1 and M2 monocyte phenotype in patients with non-small cell lung cancer(NSCLC) compared to controls. Also, to examine the expression of Th1 and Th2 cytokines in plasma of NSCLC vs controls. METHODS: Freshly prepared peripheral blood mononuclear cells samples were obtained from patients with NSCLC(lung adenocarcinoma and squamous cell lung carcinoma) and from non-cancer controls. Flow cytometry was performed to investigate M1 and M2 phenotypes in peripheral monocytes(classical monocytes CD14+, CD45+ and CD16-) using conventional surface markers. Th1 and Th2 cytokine production was alsoanalysed in the plasma using cytometric bead array technique. RESULTS: There were no significant difference in expression of M1(HLA-DR) and/or M2 markers(CD163 and CD36) markers on classical monocytes in patients with NSCLC compared to non-cancer controls. Expression of CD11 b, CD11 c, CD71 and CD44 was also shown to be similar in patients with NSCLC compared to noncancer controls. Th1 and Th2 cytokines [interleukin(IL)-1β, IL-2, IL-4, IL-5, IL-8, IL-10, IL-12(p70), tumor necrosis factor(TNF)-α, TNF-β, and interferon-γ] analysis revealed no significant difference between patients with NSCLC and non-cancer controls. CONCLUSION: This study shows no alteration in peripheral monocyte phenotype in circulating classical monocytes in patients with NSCLC compared to noncancer controls. No difference in Th1 and Th2 cytokine levels were noted in the plasma of these patients. | Saleh A Almatroodi Christine F Mc Donald Allison L Collins I an A Darby Dodie S Pouniotis | 2014 | World Journal of Clinical Oncology2014，5，5： | 2 |
| 3 | A dynamic recurrent neural network-based controller for a rigid-flexible manipulator system显示文摘 | Tian L F Collins C | 2004 | Mechatronics2004，，14： | 1 |
| 4 | Lipolysis and free fatty acid catabolism in cheese: a review of current knowledge显示文摘 | COLLINS Y F MCSWEENEY P L H WILKINSON M G | 2003 | International Dairy Journal2003，13，11： | 1 |
| 5 | Cavity expansionin sands underdrained loading conditions显示文摘 | Collins L F Pender M J | 1992 | Geomech1992，16，1： | 1 |
| 6 | Cloning and characterization of a type Ⅲ Na-dependent phosphate cotrans- porter from mouse intestine显示文摘 | Bai L Collins J F Ghishan F K | 2000 | American Journal Physiology Cell Physiology2000，279，4： | 1 |
| 7 | Gas hydrates in CO2-bearing fluid inclusions andthe use of freezing data for estimation of salinity显示文摘 | Collins P L F | 1979 | EconomicGeology1979，74，： | 1 |
| 8 | Regulation of the human sodium-phos- phate cotransporter NaPi-llb gene promoter by epidermal growth factor显示文摘 | Xu H Collins J F Bai L | 2001 | American Journal of Physiology - Cell Physiology2001，280，： | 1 |
| 9 | Cognitive existential coupletherapy for newly diagnosed prostate cancer patients and their part-ners:A descriptive pilot study显示文摘 | Collins A L Bloch S Annette F | 2011 | Psycho-oncology2011，10，2： | 1 |
| 10 | Mechanical proper- ties and microstructure analysis of fly ash geopolymeric recy- cled concrete显示文摘 | Shi X S Collins F G Zhao X L | 2012 | J Hazard Mater2012，20，29： | 1 |
| 11 | Age-dependent regulation of rat intestinal type Ⅱ b sodium-phosphate co-transporter by 1,25-(OH)2 vitamin D3显示文摘 | Xu H Bai L Q Collins J F | 2002 | Animal Journal of Physiology-Cell Physiology2002，282，： | 1 |
| 12 | Age-dependent regulation of rat intestinal type lib sodium-phosphate cotransporter by 1,25-(OH)2 vitamin D3显示文摘 | Xu H Bai L Collins J F | 2002 | Am J Physiol Cell Physiol2002，282，： | 1 |
| 13 | 查看详情显示文摘 | Landen O L Boehly T R Bradley D K Braun D G Callahan D A Celliers P M Collins G W Dewald E L Divol L Glenzer S H Hamza A Hicks D G Hoffman N Izumi N Jones O S Kirkwood R K Kyrala G A Michel P Milovich J Munro D H Nikroo A Olson R E Robey H F Spears B K Th | | 0，，： | 1 |
| 14 | Essential element, cadmium, and lead in raw and pasteurized cow and goat milk 显示文摘 | Lopez A Collins W F Williams H L | 1985 | Journal of Dairy Science1985，68，1： | 1 |
| 15 | Gas hydrates in C02-bearing fluid:inelusions and the use of freeing data for estimation of salinity显示文摘 | Collins P L F | 1979 | Economic Geology1979，74，6： | 1 |
| 16 | Effects of deoxynivalenol(DON,vomitoxin) on in utero development in rats显示文摘 | Collins Robert L | 2006 | Food and Chemical Toxicology2006，44，： | 1 |
| 17 | Rapid FTIR method for quantification of styrene-butadiene type copolymers in bitumen显示文摘 | MASSON J F PELLETIER L COLLINS P | | 0，，05： | 1 |
| 18 | An effective robot trajectory planning method using a genetic algorithm显示文摘 | TIAN L F COLLINS C | 2004 | Mechatronics2004，12，5： | 1 |
| 19 | Allelopathic potential of wheat (Triticum aestivum) straw on selected weed species显示文摘 | Steinsiek J W Oliver L R Collins F C | 1982 | Weed Science1982，30，5： | 1 |
| 20 | Mechanical properties and microstructure analysis of fly ash geopolymeric recycled concrete 显示文摘 | Shi X H Collins F G Zhao X L | 2012 | Journal of Hazardous Materials2012，20，29： | 1 |
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