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| 1 | Dynamic changes of typeⅠ,Ⅲand N collagen synthesis and distribution of collagen-producing cells in carbon tetrachloride-induced rat liver fibrosis显示文摘AIM To find out the relationship between the gene transcription of different types ofprocollagen and the deposition of the relevant collagens in the liver tissue and to confirm the types of collagen producing cells in liverfibrogenesis.METHODS Dynamic changes of the expression of α1(Ⅰ ), α1 (Ⅲ ) and α1 (Ⅳ) procollagen mRNAand relevant collagens and the distribution ofcollagen producing cells during liver fibrogenesis of rat induced by CCl4 (20 weeks)were investigated with Northern blot analysis,in situ hybridization and immunohistochemicaltechniques.RESULTS The increased expression of α1 (Ⅲ)procollagen mRNA by Northern blot analysis was the most predominant one among the threemRNAs during fibrogenesis. However, theenhanced expression of al (Ⅳ) procollagenmRNA occurred very early while the expressionof α1 (Ⅰ) mRNA was not enhanced much until themiddle stage of the exPeriment. D6smin (Dm)positive hepatic stellate cells (HSCs) and fewmyofibroblasts (MFs) in and around the necrotic areas expressed α1 (Ⅰ), α1 (Ⅲ) and α1 (Ⅳ)procollagen mRNA signals detected by in situhybridization at the early stage of theexperiment. All the three procollagen mRNAsignals thereafter mainly localized in fibroblasts (Fbs) and MFs in fibrotic septa during the middle and late stages of fibrosis, which distributedparallel to the corresponding collagens detected by immunohistochemical study. ln addition, the endothelial cells of sinusoids and the small blood vessels within the septa also showed α1(Ⅳ) procollagen mRNA and type Ⅳ collagen expressionCONCLUSION It is considered that 'HSC-MF-Fb' effect cell system is the major cellularsource of collagen production in liver fibrosis, in which HSCs are collagen producing precursor cells in the early liver fibrogenesis, thereafter the synthesis of type Ⅰ, Ⅲ and Ⅳ collagens (Col Ⅰ, Col Ⅲ and Col Ⅳ) mainly derives fromMFs and Fbs, which play a very important role in the progress of liver fibrosis. The endothelialcells along sinusoids, as another source of Col Ⅳ production, might participate in the capillization of liver sinusoids. | DU Wei-Dong ZHANG Yue-E ZHAl Wei-Rong and ZHOU Xiao-Mei(Department of Pathology, Shanghai Medical University, Shanghai200032, China)(National Laboratory for Oncogenes and Related Genes, ShanghaiCencer Institute)See invited commentary on page 388 | 1999 | World Journal of Gastroenterology1999，5，5： | 47 |
| 2 | Neovascularisation is the principal cause of varicose vein recurrence:results of a randomised trial of stripping the long saphenous vein显示文摘 | Wittens CH Commentary | | 0，，1： | 1 |
| 3 | Birth Weight and the Fetal Origins of Adult Disease显示文摘 | Commentary on the article by oliver | 2002 | Pediatr Res2002，52，： | 1 |
| 4 | Implant periapical lesion:a clinical and histologic case report显示文摘 | Norman CA Commentary | 2000 | J Oral Implantol2000，26，2： | 1 |
| 5 | Some answers,mor controversy fron UKPDS显示文摘 | Commentary | 1998 | The Lancet1998，352，： | 1 |
| 6 | Journal of Clinical Nursing 5,1317-23显示文摘 | Carter B Commentary on Shields Pratt J - Hunter J(2006) Family centred eare=a review of qualitative studies | 2008 | J Clin Nuts2008，17，15： | 1 |
| 7 | A prospective study ofacute cerebro- vascular disease in the community: the Ox-fordshire Com- munity Stroke Project, 1981-86显示文摘 | commentaries WI | 2012 | J Neurol Neurosurg Psychiatry2012，83，6： | 1 |
| 8 | Some answers,more controversy from UKPDS显示文摘 | Commentary | 1998 | The Lancet1998，，352： | 1 |
| 9 | Brain natriuretic peptide as bridge to therapy for heart failure显示文摘 | Commentary | 2000 | Lancet2000，355，： | 1 |
| 10 | Some answers, more controversy from UKPDS 显示文摘 | Commentary | 1998 | Lancet1998，352，9： | 1 |
| 11 | Some answers,more controversy from UKPDS显示文摘 | Commentary | 1998 | The lAncet1998，352，： | 1 |
| 12 | Some answers, more controversary from UKPDS 显示文摘 | Commentary | 1998 | The Lancet1998，352，： | 1 |
| 13 | The Pharmaco- logical antioxidant Amifostine implications of recent research for integrative cancer care显示文摘 | BLOEK KI GYLLENHAL C COMMENTARY | 2005 | Integr Cancer Ther2005，4，4： | 1 |
| 14 | Some answers,more controversary from UKPDS显示文摘 | Commentary | 1998 | Lancet1998，352，： | 1 |
| 15 | Some answers,more controversy from UKPDS显示文摘 | Commentary | 1998 | Lancet1998，352，9131： | 1 |
| 16 | Some Answers,More Controversy from UKPDS显示文摘 | Commentary | 1998 | The Lancet1998，352，： | 1 |
| 17 | Carotid artery plaque composition- relationship to clinical presentation and ultrasound B-mode imaging显示文摘 | Golledge J Commentary | 2011 | Eur J Vasc Endovasc Surg2011，42，： | 1 |
| 18 | Outline for an ecological economy显示文摘 | COMMENTARY H | 1995 | Scientific American1995，273，3： | 1 |
| 19 | (2010):ketamine abuse:first medical evidence of harms we should confront显示文摘 | De La Torre R Commentary on Morgan | | 0，，01： | 1 |
| 20 | Embarking on a New Journey to Build a Modern Socialist China显示文摘The Fifth Plenary Session of the CPC 19th Central Committee was held in Beijing from October 26 to 29,2020.It was an extremely important meeting given that China has in its sights the completion of its goal to build a moderately prosperous society in all respects and is about to embark on a new journey to build a modern socialist country,and it was of overall and historic significance as China is entering a new stage of development and at a critical moment in efforts to realize the rejuvenation of the Chinese nation. | Qiushi Commentary | 2020 | Qiu Shi2020，12，6： | 0 |
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