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| 1 | Clinical outcomes following salvage Gamma Knife radiosurgery for recurrent glioblastoma显示文摘Glioblastoma multiforme(GBM) is the most common malignant primary brain tumor with a survival prognosis of 14-16 mo for the highest functioning patients. Despite aggressive, multimodal upfront therapies, the majority of GBMs will recur in approximately six months. Salvage therapy options for recurrent GBM(r GBM) are an area of intense research. This study compares recent survival and quality of life outcomes following Gamma Knife radiosurgery(GKRS) salvage therapy. Following a Pub Med search for studies usingGKRS as salvage therapy for malignant gliomas, nine articles from 2005 to July 2013 were identified which evaluated rG BM treatment. In this review, we compare overall survival following diagnosis, overall survival following salvage treatment, progression-free survival, time to recurrence, local tumor control, and adverse radiation effects. This report discusses results for rG BM patient populations alone, not for mixed populations with other tumor histology grades. All nine studies reported median overall survival rates(from diagnosis, range:16.7-33.2 mo; from salvage, range:9-17.9 mo). Three studies identified median progression-free survival(range:4.6-14.9 mo). Two showed median time to recurrence of GBM. Two discussed local tumor control. Six studies reported adverse radiation effects(range:0%-46% of patients). The greatest survival advantages were seen in patients who received GKRS salvage along with other treatments, like resection or bevacizumab, suggesting that appropriately tailored multimodal therapy should be considered with each rG BM patient. However, there needs to be a randomized clinical trial to test GKRS for rG BM before the possibility of selection bias can be dismissed. | Erik W Larson Halloran E Peterson Wayne T Lamoreaux Alexander R MacKay Robert K Fairbanks Jason A Call Jonathan D Carlson Benjamin C Ling John J Demakas Barton S Cooke Christopher M Lee | 2014 | World Journal of Clinical Oncology2014，5，2： | 5 |
| 2 | Short term evaluation of carbon coated and uncoated porous titanium implants clin显示文摘 | COOK S D HADDAD R J | 1989 | Clin Mater1989，4，： | 1 |
| 3 | A study of 4-substituted 5,5-diaryl oxazolidin-2-ones as efficacious chiral auxiliaries显示文摘 | Gibson C L Gillon K Cook S | 1998 | Tetrahedron Lett1998，39，： | 1 |
| 4 | Stability and Thresholds in some Age - structured Epidemics 显示文摘 | Busenberg S Cooke K Iannelli M | 1989 | Springer Lecture Notes in Biomathematics1989，81，： | 1 |
| 5 | Curly bare (cub) ,a new mouse mutation on chromosome 11 cau- sing skin and hair abnormalities, and a modifies gene( mcub) on chromosome 5 显示文摘 | Johnson K R Lane P W Cook S A | 2003 | Genomics2003，81，1： | 1 |
| 6 | Envelope determinants of equine infectious anemia virus vaccine protection and the effects of sequence variation on immune recognition显示文摘 | Tagmyer T L Craigo J K Cook S J | 2008 | J Virol2008，82，8： | 1 |
| 7 | Tumor cell survival signaling by the ERK 1/2 pathways显示文摘 | Balmanno K Cook S J | 2009 | Cell Death Differ2009，16，3： | 1 |
| 8 | AngiotensinII can reguuulate gene expression by Ap-Ibinding sequence via a protein kinase c-dependent pathway显示文摘 | TAKEUCHI K NAKAMURA N COOK N S | 1990 | Biochem Biophys Res Comman1990，72，： | 1 |
| 9 | Relative lability of gold-oxide thin films in contact with air, solvents, or electrolyte solutions 显示文摘 | COOK K M FERGUSON G S | 2013 | Journal of Vacuum Science Technology A2013，31，021508： | 1 |
| 10 | Direct Measurement of Timing: Underpinning a Reliable Petroleum System Model for the Mid-Continent Rift System 显示文摘 | Hegarty K A Foland S S Cook A C | 2007 | AAPG Bulletin2007，91，7： | 1 |
| 11 | Effect of an informatics for evidence-hased practice currieulum on nursing informatics competencies显示文摘 | Desjardins K S Cook S S Jenkins M | 2005 | Int J Med Inform2005，74，1112： | 1 |
| 12 | Calmidazolium is a potent stimulator of steroidogenesis via mechanisms not involving cyclic AMP,calcium or protein synthesis显示文摘 | CHOI M S K COOKE B A | 1992 | Biochem J1992，281，： | 1 |
| 13 | Xenon purity analysis for exo-200 via mass spectrometry 显示文摘 | Dobi A Hall C Slutsky S Yen Y R Aharmin B Auger M Barbeau P S Benitez-Medina C Breidenbach M Cleveland B Conley R Cook J Cook S Counts I Craddock W Daniels T Davis C G Davis J Devoe R Dixit M Dolinski M J Donato K Fairbank Jr W Farine J Fierlinger P Franco D Giroux G Gornea R Graham K Gratta G Green C Hagemann C Hall K Hallman D Hargrove C Herrin S Hughes M Hodgson J Juget F Karelin A Kaufman L J Kuchenkov A Kumar K Leonard D S Lutter G Mackay D Maclellan R Marino M Mong B Montero Diez M Morgan P MUller A R Neilson R Odian A Oullivan K Piepke A Pocar A Prescott C Y Pushkin K Rivas A Rollin E Rowson P C Sabourov A Sinclair D Skarpaas K Stekhanov V Strickland V Swift M Twelker K Vuilleumier J L Vuilleumier J M Weber M Wichoski U Wodin J Wright J D Yang L | 2012 | Nuclear Instruments and Methods in Physics Research Section A: Accelerators Spectrometers Detectors and Associated Equipment2012，675，： | 1 |
| 14 | Two Approaches to Social Structure: Exchange Theory and Network Analysis显示文摘 | Cook K S Whitmeyer J M | 1992 | Annual Review of So- ciology1992，18，1： | 1 |
| 15 | Turkey rhinotracheitis:preliminary invesfigations显示文摘 | McDougall J S Cook J K | | 0，，08： | 1 |
| 16 | Further evidence for a possible role of conformation in the immunogenicity and antigenicity of the oxidative DNA lesion, 8-oxxo-2'-deoxyguanosine显示文摘 | Cooke M S Herbert K E and Butler P C | 1998 | Free Radical Research1998，28，： | 1 |
| 17 | Galactosylated polyethylenimine-graft-poly (vinylpyrrolidone) as a hepatocyte-targetinggene carrier 显示文摘 | COOK S E PARK I K KIM E M | 2005 | J Control Release2005，105，2： | 1 |
| 18 | How Smart Are Our Env ronments? An Updated Look at the State of the Art显示文摘 | Cook D J Dasb S K | 2007 | Pervasive and Mo- bile Computing2007，3，2： | 1 |
| 19 | Limb impact harvesting, part I: finite element analysis显示文摘 | Upadhyaya S K Cooke J R Rand R H | 1981 | Transactions of the ASAE1981，24，4： | 1 |
| 20 | Cytomegalovirus quantitation by real-time PCR is unaffected by delayed separation of plasma from whole blood 显示文摘 | Nesbitl S E Cook L Jeronle K R | 2004 | J Clin Microbiol2004，42，3： | 1 |
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