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| 1 | 抗生素耐药性环境中产生和转移的人类健康风险评估(HHRA)显示文摘[背景]直到最近,人们才明确环境能影响抗生素耐药性风险对临床结果的影响,但迄今为止,很少有文献记录正式评估这些风险的方法。[目标]我们研究可能的方法,并试图确定人类健康风险评估(HHRA)的研究需求,这项评估注重环境在抗生素耐药性病原体所致的抗生素治疗失败中所起的作用。[方法]作者参加了2012年3月4—8日在加拿大魁北克省举行的研讨会,定义抗生素耐药性风险与人类健康环境评估的范围和目标。我们专注于环境中耐药性产生'热点区域'的关键要素,(与食品无关的)暴露评估以及剂量反应,以描述风险特征,从而改善抗生素耐药性管理的方案。[讨论]识别传统风险评估中有助于评估环境中抗生素耐药性的各个新方面。包括:a)解释附加的选择压力对环境耐药基因组的作用,即随着时间的推移,促使抗生素耐药性细菌(ARB)产生;b)在相关的环境组成部分的'热点区域'中识别和描述水平基因转移(HGT)率;c)针对不同健康结局和途径的ARB剂量修改传统的剂量反应方法。[结论]我们建议将抗生素耐药性产生造成的环境影响纳入所有涉及ARB的HHRA过程之中。由于可用的数据有限,一种多标准决策分析方法将有助于进行环境中抗生素耐药性的HHRA,并使风险管理者了解环境抗生素耐药性。 | Nicholas J.Ashbolt Alejandro Amézquita Thomas Backhaus Peter Borriello Kristian K.Brandt Peter Collignon Anja Coors Rita Finley William H.Gaze Thomas Heberer John R.Lawrence D.G.Joakim Larsson Scott A.McEwen James J.Ryan Jens Schnfeld Peter Silley Jason R.Snape Christel Van den Eede Edward Topp 王晓宇 张伊人 操仪 | 2014 | 环境与职业医学2014，31，2： | 3 |
| 2 | Impact of the maturity of corn for use as silage in the diets of dairy cows on intake,digestion, and milk production显示文摘 | BALM A Coors J G Shaver R D | 1997 | J Dairy1997，80，： | 2 |
| 3 | Ear-fill effects on field and quality of silage corn显示文摘 | Coors J G Bures E J | 1997 | Crop Sci1997，37，： | 2 |
| 4 | Polysorbate 80 in medical products and nonimmunologic anaphylactoid reactions 显示文摘 | Coors EA Seybold H Merk HF | 2005 | Ann Allergy Asthma Immunol2005，95，6： | 1 |
| 5 | Twenty-four cycles of mass selection for prolificacy in the Golden Glow maize population 显示文摘 | Leon T N Coors J G | 2002 | Crop Science2002，42，2： | 1 |
| 6 | Treatment of erythrodermic cutaneous T-cell lymphoma with intermittent chlorambucil and fluocortolone therapy显示文摘 | Coors EA Von den DP | 2000 | Br J Dematol2000，143，1： | 1 |
| 7 | Genetic analysis of tolerance to low-phosphorus stress in maize using restrictionfragment length polymorphisms 显示文摘 | REITER R S COORS J G SUSSMAN M R | 1991 | Theor Appl Genet1991，82，5： | 1 |
| 8 | Impact of the maturity of corn for use as silage in the diets of dairy cows on intake, digestion, and milk production 显示文摘 | Bal M A Coors J G Shaver R D | 1997 | J Dairy Sei1997，80，10： | 1 |
| 9 | Genetic analysis of tolerance to low phosphorus stress in maize using restriction fragment length polymorphisms 显示文摘 | Reiter R Coors J Sussman M | 1991 | Theoretical and Applied Genetics1991，82，： | 1 |
| 10 | Gentic analysis of tolerance to low-phosphorus stress in maize using restriction frogmentlength polymorphisms显示文摘 | Reiter R S Coors J G Sussman M R | 1991 | Theor Appl Genet1991，82，： | 1 |
| 11 | The product of the tobacco mosaic virus resistance gene N: similarity to toll and the interleukin-1 receptor 显示文摘 | Whitham S Dinesh-kumar S P Choi D Hehl R Coor C Baker B | 1994 | Cell1994，78，： | 1 |
| 12 | Earfill effects on yield and quality of silage corn显示文摘 | Coors J G Bures E J | | 0，，： | 1 |
| 13 | 3D - GIS in networking environments 显示文摘 | Volker Coors | 2002 | Computers Environment and Urban Systems2002，274，： | 1 |
| 14 | 3D-GIS in networking environments 显示文摘 | Volker Coors | 2003 | Computers Environment and Urban Systems2003，27，2： | 1 |
| 15 | 3D GIS in Networking environments显示文摘 | Coors V | | 0，，04： | 1 |
| 16 | Topical photodynamic therapy for patients with therapy-resistant lesions of cutaneous T-cell lymphoma 显示文摘 | Coors EA yon den Driesch P | 2004 | J Am Acad Dennatot2004，50，6： | 1 |
| 17 | Topical photodynamie therapy for patients with therapy-resistant lesions of cutaneous T-cell lymphoma显示文摘 | Coors EA von den Driesch P | 2004 | J Am Acad Dermatol2004，50，3： | 1 |
| 18 | Genetic analysis of tolerance to low-phosphorus stress in maize using restriction fragment length polymorphisms显示文摘 | R. S. Reiter J. G. Coors M. R. Sussman W. H. Gabelman | 1991 | Theoretical and Applied Genetics1991，，5： | 1 |
| 19 | 3D GIS in networking environments显示文摘 | Coors V | 2003 | Computer Environment and Urbaqn Systems2003，27，4： | 1 |
| 20 | Lax leaf maize cell wall composition and nutritional value显示文摘 | Falkner L K Coor J G Ostrander B M | 2000 | Journal of the science of food and garicultuer2000，80，25： | 1 |
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