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| 1 | Current view and perspectives in amyotrophic lateral sclerosis显示文摘Amyotrophic lateral sclerosis(ALS), identified as a distinct clinical entity by Charcot since the end of the nineteenth century, is a devastating and fatal neurodegenerative disorder that affects motor neurons in the brain, brainstem and spinal cord. Survival of patients with ALS is associated with several factors such as clinical phenotype, age at onset, gender, early presence of respiratory failure, weight loss and treatment with Riluzole(the only disease-modifying drug approved for this disease). Nowadays, there is still no curative treatment for ALS: palliative care and symptomatic treatment are therefore essential components in the management of these patients. Nevertheless, the scientific knowledge in the field of ALS motor neuron degeneration is growing, with the prospect of new treatments. Based on this physiopathological knowledge, several new therapeutic targets are being studied, involving various mechanisms such as excitotoxicity, neuroinflammation, mitochondrial dysfunction, oxidative stress, RNA metabolism and other attractive concepts. Moreover, it is also important to identify reliable biomarkers that will be essential components for future therapeutic development and study design in ALS. In this review, we present the main recent advances and promising therapeutics and biomarkers in the field of ALS. | Stéphane Mathis Philippe Couratier Adrien Julian Philippe Corcia Gwendal Le Masson | 2017 | Neural Regeneration Research2017，12，2： | 3 |
| 2 | A simple and rapid confirmatory assay for analyzing antibiotic residues of the macrolide class and lincomycin in bovine milk and yoghurt:hot water extraction followed by liquid chromatography/tandem mass spectrometry显示文摘 | BOGIALLI S DI CORCIA A LAGAN(A)A | | 0，，02： | 1 |
| 3 | Recent applicati- ons of liquid chromatography-mass spectrometry to residue analysis of antimicrobials in food of an- imal origin 显示文摘 | BOGIALLI S DI CORCIA A | 2009 | Analytical and BioanalytiealChemistry2009，395，4： | 1 |
| 4 | Fate of natural estrogen conjugates in municipal sewage transport and treatment facilities 显示文摘 | D' Ascenzo G Di Corcia A Gentili A | 2003 | Science of the Total Environment2003，302，123： | 1 |
| 5 | A rapid method based on hot water extraction and liquid chromatography-tan- dem mass spectrometry for analysing tetracycline antibiotic re- sidues in cheese 显示文摘 | Bogialli S Coradazzi C Di Corcia A | 2007 | JAOAC Int2007，90，3： | 1 |
| 6 | Causes of death in a post- mortem series of ALS patients 显示文摘 | Corcia P Pradat PF Salachas F | 2008 | Amyotroph Lateral Scler2008，9，1： | 1 |
| 7 | Elevated serum ferritin is associated with reduced survival in amyotrophic lateral sclerosis 显示文摘 | Nadjar Y Gordon P Corcia P et at | 2012 | PLoS One2012，7，45： | 1 |
| 8 | Serum insulin and leptin levels and valproate-associated obesity显示文摘 | Verrotti A di Corcia G Salladini C | 2003 | Epilepsia2003，44，： | 1 |
| 9 | A liquid chromatography? mass spectrometry assay for analyzing sulfonamide antibacterials in cattle and fish muscle 显示文摘 | BOGIALLI S CURINI R DI CORCIA A | 2003 | Anal Chem2003，75，8： | 1 |
| 10 | Malnutrition at the time of diagnosis is associated with a shorter disease duration in ALS显示文摘 | Limousin N Blasco H Corcia P | 2010 | J Neurol Sci2010，297，： | 1 |
| 11 | Fate of natural estrogen conjugates in municipal sewage transport and treatment facilities显示文摘 | D'ASCENZO G CORCIA A D GENTILI A | 2003 | Sci Total Environ2003，302，123： | 1 |
| 12 | Development of a multiresidue method for analyzing herbicide and fungicide residues in bovine milk based on solid-phase extraction and liquid chromatography - tandem mass spectrometry显示文摘 | BOGIALI I S CURINI R CORCIA A D | 2006 | J Chromatogr: A2006，1102，： | 1 |
| 13 | Estimating steroid oestrogen inputs into activated sludge treatment works and observations on their removal from the effluent显示文摘 | Johnson A C Belfroid A Di Corcia A | | 0，，： | 1 |
| 14 | Dyslipidemia is a protective factor in amyotrophie lateral sclerosis 显示文摘 | Dupuis L Corcia P Ferguni A | 2008 | Neurology2008，70，13： | 1 |
| 15 | Solid-phase extraction followed by liquid chromatography-mass spectrometry for trace determination of beta-lactam antibiotics in bovine milk显示文摘 | BRUNO F CURINI R DI CORCIA A | 2001 | J Agric Food Chem2001，49，7： | 1 |
| 16 | A simple and sensitive liquid chromatography-mass spectrometry confirmatory method for analyzing sulfonmide antibacterials in milk and egg显示文摘 | Cavaliere C Curini R Corcia A N | 2003 | J Agricul and Food Chem2003，51，： | 1 |
| 17 | Liquid chromatographic-mass spectrometric methods for analyzing antibiotic and antibacterial agents in animal food products显示文摘 | DI CORCIA A NAZZARI M | 2002 | J Chromatogr A2002，974，1： | 1 |
| 18 | Estimating steroid estrogen inputs into activated sludge treatment works and observations on their removal from the effluent显示文摘 | JOHNSON A C BELFROID A DI CORCIA a | 2000 | The Science of the Total Environment2000，2，256： | 1 |
| 19 | Determination of tetracyclines in multi-specie animal tissues by pressurized liquid extraction and liquid chromatography-tandem mass spectrometry 显示文摘 | BLASCO C CORCIA A D PICO Y | 2009 | Food Chemistry2009，116，4： | 1 |
| 20 | Evaluation of a method based on liquid chromatography/electrospray/mass spectrometry for analyzing carbamate insecticides in fruits and vegetables显示文摘 | Corcia AD Crescenzi C Lagana A | 1996 | Journal of Agricultural and Food Chemistry1996，44，： | 1 |
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