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| 1 | Acute effects of rotavirus and malnutrition on intestinal barrier function in neonatal piglets显示文摘AIM: To investigate the effect of protein-energy malnutrition on intestinal barrier function during rotavirus enteritis in a piglet model.METHODS: Newborn piglets were allotted at day 4 of age to the following treatments:(1) full-strength formula(FSF)/noninfected;(2) FSF/rotavirus infected;(3) half-strength formula(HSF)/noninfected;or(4) HSF/rotavirus infected.After one day of adjustment to the feeding rates,pigs were infected with rotavirus and acute effects on growth and diarrhea were monitored for 3 d and jejunal samples were collected for Ussingchamber analyses.RESULTS: Piglets that were malnourished or infected had lower body weights on days 2 and 3 post-infection(P < 0.05).Three days post-infection,marked diarrhea and weight loss were accompanied by sharp reductions in villus height(59%) and lactase activity(91%) and increased crypt depth(21%) in infected compared with non-infected pigs(P < 0.05).Malnutrition also increased crypt depth(21%) compared to full-fed piglets.Villus:crypt ratio was reduced(67%) with viral infection.There was a trend for reduction in transepithelial electrical resistance with rotavirus infection and malnutrition(P = 0.1).3H-mannitol flux was significantly increased(50%;P < 0.001) in rotavirus-infected piglets compared to non-infected piglets,but there was no effect of nutritional status.Furthermore,rotavirus infection reduced localization of the tight junction protein,occludin,in the cell membrane and increased localization in the cytosol.CONCLUSION: Overall,malnutrition had no additive effects to rotavirus infection on intestinal barrier function at day 3 post-infection in a neonatal piglet model. | Sheila K Jacobi Adam J Moeser Anthony T Blikslager J Marc Rhoads Benjamin A Corl Robert J Harrell Jack Odle | 2013 | World Journal of Gastroenterology2013，19，31： | 4 |
| 2 | Trans-10, cis-12 conjugated linoleic acid decreases lipogenic rates and expression of genes involved in milk lipid synthesis in dairy cows显示文摘 | BAUMGARD L H MATITASHVILI E CORL B A | 2002 | Dairy Sci2002，85，： | 1 |
| 3 | Imaging of renal trauma :a comprehensive review 显示文摘 | Kawashima A Sandier CM Corl FM | 2001 | Radiographics2001，21，3： | 1 |
| 4 | Transcriptional regulation of lipid synthesis in bovine mammary epithelial cells by sterol regulatory element binding protein-1显示文摘 | Ma L Corl B A | 2012 | J Dairy Sci2012，95，7： | 1 |
| 5 | Conjugated linoleic aoid is synthesized endogenously in lactating dairy cows by 9- desaturase显示文摘 | Griinari J M Corl B A Lacy S H | 2000 | J Nutr2000，130，9： | 1 |
| 6 | Effect of animal plasma proteins on intestinal damage and recovery of neonatal pigs infected with rotavirus显示文摘 | Corl B A Harrell R J Moon H K | 2007 | J Nutr Bio2007，18，： | 1 |
| 7 | The Effect of Breed, Parity, and Stage of Lactation on Conjugated Linoleic Acid (CLA) in Milk Fat from Dairy Cows显示文摘 | KELSEY J A CORL B A COLLIER R J | 2003 | J Dairy Sci2003，86，： | 1 |
| 8 | Imaging of renal trauma: a comprehensive review 显示文摘 | KAWASHIMA A SANDLER C M CORL F M et at | 2001 | Radiographics2001，21，3： | 1 |
| 9 | Conjugated Linoleic Acid is Synthesized Endogenously in Lactating Dairy Cows by △9- Desaturase显示文摘 | GRIINARI J M CORL B A LACY S H | 2000 | J Nutr2000，130，： | 1 |
| 10 | Regulation of lipid synthesis by liver X receptorαand sterol regulatory element-binding protein 1in mammary epithelial cells显示文摘 | Oppi-williams C Suagee J K Corl B A | 2013 | J Dairy Sci2013，96，： | 1 |
| 11 | Conjugated linoleic acid is synthesized endogenously in lactating dairy cows by A9- desaturase 显示文摘 | GRIINARI J M CORL B A LACY S H | 2000 | J Nutr2000，130，9： | 1 |
| 12 | Shifts in bovine CD4+ subpopulations increase TH-2 compared to TH-1 effector cells during the postpartum period显示文摘 | Shafer-Weaver K A C M Corl L M Sordillo | 1999 | Dairy Science1999，82，： | 1 |
| 13 | Conjugated linoleic acid is synthesized endogenously in lactating dairy cows by delta(9)- desaturase显示文摘 | Griinari J M Corl B A Lacy S H | 2000 | The Journal of Nutrition2000，130，9： | 1 |
| 14 | Identification and characterization of a novel bovine stearoyl-CoA desaturase isoform with homology to human SCD5 显示文摘 | Lengi A J Corl B A | 2007 | Lipids2007，42，6： | 1 |
| 15 | Muscarinic suppression ofCa2+ - dependent K currentin colonic smooth muscle 显示文摘 | Cole WC Corl A Sanders KM | 1989 | Am J Physiol1989，257，： | 1 |
| 16 | Trans-lO, cis-12 conjugated linoleic acid decreases lipogenic rates and expression of genes involved in milk lipid synthesis in dairy cows显示文摘 | Baumgard L H Matitashvili E Corl B A | 2002 | Journal of Dairy Science2002，85，： | 1 |
| 17 | Theeffect of breed,parity,and stage of lactation on con-jugated linoleic acid (CLA) in milk fat from dairycows显示文摘 | KELSEY J A CORL B A COLLIER RJ | 2003 | J Dairy Sci2003，86，8： | 1 |
| 18 | Intestinal ribosomal p70 (S6K) signaling is increased in piglet rotavirus enteritis显示文摘 | RHOADS J M CORL B A HARRELL R | 2007 | American Journal of Physiology:Gastrointestinal and Liver Physiology2007，292，3： | 1 |
| 19 | Effect of animal plasma proteins on intestinal damage and recovery of neonatal pigs infected with rotavirus显示文摘 | Corl B A Harrell R J Moon H K | 2007 | The Journal of Nutritional Biochemistry2007，18，12： | 1 |
| 20 | Imaging of renal trauma: a comprehensive review 显示文摘 | Kawashima A Sandier CM Corl FM | 2001 | Radiographics2001，21，2： | 1 |
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