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| 1 | Autopsy analysis ofthe implantation site of a permanent selective direct his bundle pacinglead 显示文摘 | Correa de Sa DD Hardin NJ Crespo EM | 2012 | Circ Arrhythm Electrophysiol2012，5，： | 1 |
| 2 | Autopsy analysis of the implantation site of a permanent selective direct his bundle pacing lead显示文摘 | Correa de Sa DD Hardin NJ Crespo EM | 2012 | Circ Arrhythm Electrophysiol2012，5，1： | 1 |
| 3 | Comprehensive analysis of HFE gene in hereditary hemochromatosis and in diseases associated with acquired iron overload显示文摘BACKGROUND Patients with hepatitis C virus(HCV) and hepatocellular carcinoma(HCC) may or not develop iron overload(IO),which is associated with worst prognosis,because can cause serious damage to organs.HFE gene controls the iron uptake from gut,particularly in patients with hereditary hemochromatosis(HH).AIM To identify associations between HFE coding region in patients exhibiting hereditary hemochromatosis and in diseases associated with acquired IO.METHODS We sequenced exons 2 to 5 and boundary introns of HFE gene,evaluating all polymorphic sites in patients presenting hereditary(hemochromatosis) or acquired iron overload HCV and HCC) and in healthy controls,using Sanger sequencing.We also determined the ensemble of extended haplotype in healthy control individuals,including several major histocompatibility complex loci,using sequence specific probes.Haplotype reconstruction was performed using the Arlequin and Phase softwares,and linkage disequilibrium(LD) between histocompatibility loci and HFE gene was performed using the Haploview software.RESULTS The HFE*003 allele was overrepresented(f = 71%) and HFE*001 allele was underrepresented(f = 14%) in HH patients compared to all groups.A strong linkage disequilibrium was observed among the H63 D-G,IVS2(+4)-C and C282 YG gene variants,particularly in HH;however,the mutation IVS2(+4)T>C was not directly associated with HH susceptibility.The HFE*001/HFE*002 genotype conferred susceptibility to HCC in HCV patients exhibiting IO(P = 0.02,OR =14.14).Although HFE is telomeric to other histocompatibility genes,the H63 DG/IVS2(+4)-C(P ≤ 0.00001/P ≤ 0.0057) combination was in LD with HLA-B*44 allele group in healthy controls.No LD was observed between HFE alleles and other major histocompatibility loci.CONCLUSION A differential HFE association was observed for HH and for diseases associated with acquired IO(HCV,HCC).Since HFE is very distant from other histocompatibility loci,only weak associations were observed with these alleles. | Wagner Narciso de Campos Juliana Doblas Massaro Eduardo Luiz Rachid Can?ado Cláudia Emília Vieira Wiezel Aguinaldo Luiz Sim?es Andreza Correa Teixeira Fernanda Fernandes de Souza Celso Teixeira Mendes-Junior Ana de Lourdes Candolo Martinelli Eduardo Ant?nio Donadi | 2019 | World Journal of Hepatology2019，11，2： | 1 |
| 4 | Autopsy analysis ofthe implantation site of a permanent selective direct his bundlepacing lead显示文摘 | Correa de Sa DD Hardin NJ Crespo EM | 2012 | Circ Arrhythm Electrophysiol2012，5，1： | 1 |
| 5 | Mutations in the SRY, DAX1,SF1 and WNT4 genes in Brazilian sex-reversed patients显示文摘 | Domenice S Correa RV Costa EM | 2004 | Braz J Med Biol Res2004，37，1： | 1 |
| 6 | Height and bone mineral density in androgen insensitivity syndrome with mutations in the androgen receptor gene显示文摘 | Danilovic DL Correa PH Costa EM | 2007 | Osteoporos Int2007，18，3： | 1 |
| 7 | Analysis of DNA structure and sequence requirements for Pseudomonas aeruginosa MutL endonuclease activity显示文摘 | Correa EM De Tullio L Velez PS | 2013 | J Biochem2013，154，6： | 1 |
| 8 | Autopsy analysis of the implantation site of a permanent selective direct his bundle pacing lead显示文摘 | Correa DSD Hardin N J Crespo EM | 2012 | Cire Arrhythm Electrophysiol2012，5，1： | 1 |
| 9 | Some amino acids of the Pseudomonas aeruginosa MutL D(Q/M)HA(X)(2)E(X)(4)E conserved motif are essential for the in vivo function of the protein but not for the in vitro endonuclease activity显示文摘 | Correa EM Martina MA De Tullio L | 2011 | DNA Repair(Amst)2011，10，11： | 1 |
| 10 | Mutations in the SRY, DAX1, SF1 and WNT4 genes in Brazilian sex- reversed patients 显示文摘 | Domenice S Correa RV Costa EM | 2004 | BrazJMedBiolRes2004，37，1： | 1 |
| 11 | The forehead flap: the gold standard of nasal soft tissue reconstruction 显示文摘 | CORREA B J WEATHERS WM WOLFSWINKEL EM | 2013 | Semin Plast Surg2013，27，2： | 1 |
| 12 | Autopsy analysis of the implantation site of a permanent selective direct his bundle pacing lead显示文摘 | Correa de Sa DD Hardin NJ Crespo EM | 2012 | Circ Arrhythm Electrophysiol2012，5，1： | 1 |
| 13 | Autopsy analysis of the implantation site of a permanent selective direct his bundle pacing lead显示文摘 | Correa D SD Hardin NJ Crespo EM | 2012 | Circ Arrhythm Electrophysiol2012，5，1： | 1 |
| 14 | Mutations in the SRY, DAX1, SF1 andWNT4 genes in Brazilian sex- reversed patients 显示文摘 | Domenice S Correa RV Costa EM | 2004 | Brazilian Journal of Medical and Biological Research2004，37，： | 1 |
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