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| 1 | 美国湿地保护制度变迁研究显示文摘本文提出了分析湿地保护制度变迁的理论框架,使不同国家的湿地保护制度研究能在统一语境下比较。首先基于科学计量学和系统研究方法筛选出公众、科学、政府和法律为影响湿地保护制度变迁的四个关键要素,并依赖博弈论工具建立了分析美国湿地保护制度的理论架构。基于这一架构,本文对包括关键利益相关者、政策执行路径、政策工具和管理挑战等内容的美国湿地政策史进行了讨论。对美国湿地保护制度的演化进行了四阶断之划分:'西进运动'与全民开垦(1900年之前)、'水鸟保护'与公众参与(1900-1970年)、核心法律与科学研究(1971-1980年)和完善制度与新的挑战(1980年至今)。分析得出如下结论:在湿地保护制度中,公众是源头、科学是前提、有效的政府管治和将湿地保护的规则和与政策制度化是关键。通过借鉴美国湿地保护制度变迁研究,本文构建了湿地保护制度变迁的'竹节模式'经验性模型,揭示了各动因之间的作用机理。虽然美国湿地保护制度也面临着公众教育、科学定义和政府管辖权等挑战,但中国的湿地管理者与政策制定者仍可从美国湿地政策执行的历史背景中吸取经验。同时本文的理论分析结构也可为自然资源及管理策略的研究提供参考。 | 陈溪 Magdeline Laba Robertson Morgan Barbara Cosens 王子彦 陈雪 James Anderson Marinus Otte Christopher Craft David Feldman 李杨帆 刘晶岚 Patrick Sullivan 吕宪国 | 2016 | 资源科学2016，38，4： | 13 |
| 2 | Relaxin prevents the development of severe acute pancreatitis显示文摘瞄准:为了调查尖锐胰腺炎(AP ) 的严厉,被联系到白血球激活,煽动性的起来规定和联系到 ischemia-reperfusion 损害的微循环混乱的紧张。支持 inflammatory 调停人的 Microvascular 完整和抑制在 AP 的进化是关键因素的。松弛激素是被归因的像胰岛素的荷尔蒙经由氮的氧化物小径的 vasorelaxant 性质当作为糖皮质激素受体收缩筋表现时。方法:AP 被 bilio 胰腺的 duct-outlet-exclusion closed-duodenal-loops 模型导致。有松弛激素的处理在不同时间点被做。由由 mifepristone 的阻塞被考虑的 L 名字和糖皮质激素受体(GR ) 的氮的氧化物 synthase 抑制。AP 严厉被生物化学、组织病理学说的分析估计。结果:有松弛激素的处理减少了浆液淀粉酶,脂肪分解酵素, C 反应的蛋白质, IL-6, IL-10, hsp72, LDH 和 8-isoprostane 象一样胰腺并且肺 myeloperoxidase。腺泡和脂肪坏死,出血和 neutrophil 渗透也被减少。当 caspases 2-3-8 和 9 项活动被增加时, ATP 弄空和 ADP/ATP 比率被减少。L 名字和 mifepristone 减少了松弛激素的效率。结论:松弛激素结果在当保存微发行量并且在坏死上赞成 apoptosis 时,联合 GR 收缩筋的性质的 AP 的处理有益。 | Laura Iris Cosen-Binker Marcelo Gustavo Binker Rodica Cosen Gustavo Negri Osvaldo Tiscornia | 2006 | World Journal of Gastroenterology2006，12，10： | 10 |
| 3 | Chronic stress sensitizes rats to pancreatitis induced by cerulein:Role of TNF-α显示文摘AIM:To investigate chronic stress as a susceptibility factor for developing pancreatitis,as well as tumor necrosis factor-α (TNF-α) as a putative sensitizer.METHODS:Rat pancreatic acini were used to analyze the influence of TNF-α on submaximal (50 pmol/L) cholecystokinin (CCK) stimulation.Chronic restraint (4 h every day for 21 d) was used to evaluate the effects of submaximal (0.2 μg/kg per hour) cerulein stimulation on chronically stressed rats.RESULTS:In vitro exposure of pancreatic acini toTNF-α disorganized the actin cytoskeleton.This was further increased by TNF-α/CCK treatment,which additionally reduced amylase secretion,and increased trypsin and nuclear factor-κB activities in a protein-kinase-C δ and ε-dependent manner.TNF-α/CCK also enhanced caspases' activity and lactate dehydrogenase release,induced ATP loss,and augmented the ADP/ATP ratio.In vivo,rats under chronic restraint exhibited elevated serum and pancreatic TNF-α levels.Serum,pancreatic,and lung inflammatory parameters,as well as caspases' activity in pancreatic and lung tissue,were substantially enhanced in stressed/cerulein-treated rats,which also experienced tissues' ATP loss and greater ADP/ATP ratios.Histological examination revealed that stressed/cerulein-treated animals developed abundant pancreatic and lung edema,hemorrhage and leukocyte infiltrate,and pancreatic necrosis.Pancreatitis severity was greatly decreased by treating animals with an anti-TNF-αantibody,which diminished all inflammatory parameters,histopathological scores,and apoptotic/necrotic markers in stressed/cerulein-treated rats.CONCLUSION:In rats,chronic stress increases susceptibility for developing pancreatitis,which involves TNF-α sensitization of pancreatic acinar cells to undergo injury by physiological cerulein stimulation. | Marcelo G Binker Andres A Binker-Cosen Daniel Richards Herbert Y Gaisano Rodica H de Cosen Laura I Cosen-Binker | 2010 | World Journal of Gastroenterology2010，16，44： | 7 |
| 4 | Rac1 inhibition decreases the severity of pancreatitis and pancreatitis-associated lung injury in mice显示文摘 | BINKER M G BINKER COSEN A A GAISANO H Y | 2008 | Exp Physiol2008，93，10： | 1 |
| 5 | Influence of stress in acute pancreatitis and correlation with stress - induced gastric ulcer 显示文摘 | Cosen - Binker LI Binker MG Negri G | 2004 | Pancreatology2004，4，16： | 1 |
| 6 | Abnormal electroretinogram from a Drosophila mutant 显示文摘 | Cosens DJ Manning A | 1969 | Nature1969，224，： | 1 |
| 7 | Development of drinking water standards for perchlorate in the United States显示文摘 | Kucharzyk K H Crawford R L Cosens B | 2009 | Journal of Environmental Management2009，91，2： | 1 |
| 8 | Hypoxia–reoxygenation increase invasiveness of PANC-1 cells through Rac1/MMP-2显示文摘 | Marcelo G. Binker Andres A. Binker-Cosen Daniel Richards Herbert Y. Gaisano Rodica H. de Cosen Laura I. Cosen-Binker | 2010 | Biochemical and Biophysical Research Communications2010，，3： | 1 |
| 9 | Abnormal electroretinogram from a Drosophila mutant显示文摘 | Cosens DJ Manning A | 1969 | Nature1969，224，18： | 1 |
| 10 | Abnormal electroretinogram from a Drosophila mutant显示文摘 | Cosens D J Manning A | 1969 | Nature1969，224，5216： | 1 |
| 11 | Alcohol redirects CCK- mediated apical exocytosis to the acinar basolateral membrane in alcoholic pancreatitis显示文摘 | Lam PP Cosen Binker LI Lugea A | 2007 | Traffic2007，8，5： | 1 |
| 12 | Abnormal eleetroretinogram from a Drosophila mutant 显示文摘 | Cosens D J Manning A | 1969 | Nature1969，224，： | 1 |
| 13 | Influenceof nitric oxide-donating nonsteroidal anti-inflammatorydrugs on the evolution of acute pancreatitis显示文摘 | Cosen-Binker LI Binker MG Cosen R | 2006 | Shoe2006，25，2： | 1 |
| 14 | Resilience and water governance: adaptive governance in the Columbia River Basin显示文摘 | COSENS B WILLIAMS M | 2012 | Ecology and Society2012，17，4： | 1 |
| 15 | Abnormal electroretinogram from aDrosophila mutant显示文摘 | Cosens D J Manning A | 1969 | Nature1969，224，5216： | 1 |
| 16 | Resilience in transboundary water governance : the okavango river basin 显示文摘 | GREEN O O COSENS B A GARMESTANI A S | 2013 | Ecology & Society2013，18，2： | 1 |
| 17 | Influence of nitric oxide-donating nonsteroidal anti-inflammatory drugs on the evolution of acute pancreatitis显示文摘 | Cosen-Binker LI Binker MG Cosen R | 2006 | Shock2006，25，2： | 1 |
| 18 | Abnormal electroretinogram from a drosophila mutant显示文摘 | Cosens DJ Manning A | | 0，，5216： | 1 |
| 19 | Abnormal electroretinogram from a Drosophila mutant显示文摘 | Cosens DJ Manning A | 1969 | Nature1969，224，5216： | 1 |
| 20 | Influence of nitric oxide-donating nonsteroidal anti-inflammatory drugs on the evaluation of acute pancreatitis显示文摘 | Cosen-Binker LI Binker MG Cosen R | 2006 | Shock2006，25，2： | 1 |
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