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| 1 | Correlation of N-myc downstream-regulated gene 1 expression with clinical outcomes of colorectal cancer patients of different race/ethnicity显示文摘AIM: To evaluate the role of N-myc downstream-regulated gene 1 (NDRG1) expression in prognosis and survival of colorectal cancer patients with different ethnic backgrounds. METHODS: Because NDRG1 is a downstream target of p53 and hypoxia inducible factor-1α (HIF-1α),we examined NDRG1 expression together with p53 and HIF-1α by immunohistochemistry. A total of 157 colorectal cancer specimens including 80 from Japanese patients and 77 from US patients were examined. The correlation between protein expression with clinicopathological features and survival after surgery was analyzed.in colorectal tumor compared with normal epithelium in both Japanese and US patient groups. Expression of NDRG1 protein was significantly correlated with lymphatic invasion,venous invasion,depth of invasion,histopathological type,and Dukes' stage in Japanese colorectal cancer patients. NDRG1 expression was correlated to histopathological type,Dukes' stage and HIF-1α expression in US-Caucasian patients but not in US-African American patients. Interestingly,Kaplan-Meier survival analysis demonstrated that NDRG1 expression correlated significantly with poorer survival in US-African American patients but not in other patient groups. However,in p53-positive US cases,NDRG1 positivity correlated significantly with better survival. In addition,NDRG1 expression also correlated significantly with improved survival in US patients with stages Ⅲ and Ⅳ tumors without chemotherapy. In Japanese patients with stages Ⅱ and Ⅲ tumors,strong NDRG1 staining in p53-positive tumors correlated significantly with improved survival but negatively in patients without chemotherapy. CONCLUSION: NDRG1 expression was correlated with various clinicopathological features and clinical outcomes in colorectal cancer depending on the race/ethnicity of the patients. NDRG1 may serve as a biological basis for the disparity of clinical outcomes of colorectal cancer patients with different ethnic backgrounds. | Minori Koshiji Kensuke Kumamoto Keiichirou Morimura Yasufumi Utsumi Michiko Aizawa Masami Hoshino Shinji Ohki Seiichi Takenoshita Max Costa Thérèse Commes David Piquemal Curtis C Harris Kam-Meng Tchou-Wong | 2007 | World Journal of Gastroenterology2007，13，20： | 25 |
| 2 | Xestospongins:potent membrane permeable blockers of the inositol 1,4,5-trisphosphate receptor显示文摘 | Gafni J Munsch JA Lam TH Catlin MC Costa LG Molinski TF | 1997 | Neuron1997，19，3： | 1 |
| 3 | Positron emission tomography and colorectal cancer显示文摘 | Arulampalam TH Costa DC Loizidou M | 2001 | Br J Surg2001，88，2： | 1 |
| 4 | A simplified system for generating recombinant adenoviruses 显示文摘 | He TH Zhou SB da Costa LT | 1998 | Proc Natl Acad Sci USA1998，95，： | 1 |
| 5 | Enhanced programmed death l(PD-1)and PD-1 ligand(PD-L1)expression in patients with actinic cheilitis and oral squamous cell carcinoma显示文摘 | Malaspina TS Gasparoto TH Costa MR et at | 2011 | Cancer Immunol Immunother2011，60，7： | 1 |
| 6 | Enhanced pro- grammed death 1 ( PD - 1 ) and PD - 1 ligand ( PD - L1 ) ex- pression in patients with actinic cbeilitis and oral squamous cell carcinoma显示文摘 | Malaspina TS Gasparoto TH Costa MR | 2011 | Cancer Immunol Immunother2011，60，7： | 1 |
| 7 | Association between Chro- nic Apical Periodontitis and Coronary Artery Disease 显示文摘 | Costa TH Nero JA de Oliveira AE | 2014 | J Endod2014，40，2： | 1 |
| 8 | Association between chronic apical periodontitis and coronary artery disease显示文摘 | Costa TH Nero JA de Oliveira AE | 2014 | J Endod2014，40，2： | 1 |
| 9 | Dinuclear, Bishydrated GdⅢ Polyaminocarboxylates with a Rigid Xylene Core Display Remarkable Proton Relaxivities显示文摘 | Costa J Tóth Helm L | 2005 | Inorg Chem2005，44，13： | 1 |
| 10 | Associa- tion between chronic apical periodontitis and coronary artery dis- ease 显示文摘 | Costa TH de Figueiredo Neto JA de Oliveira AE | 2014 | J Endod2014，40，2： | 1 |
| 11 | Alterations inmyocardial lipid metabolism duringlactation in the rat显示文摘 | WangX Hole DG Da Costa TH | | 0，，： | 1 |
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