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| 1 | Fatty liver disease in severe obese patients:Diagnostic value of abdominal ultrasound显示文摘AIM:To evaluate the sensitivity and specificity of abdominal ultrasound (US) for the diagnosis of hepatic steatosis in severe obese subjects and its relation to histological grade of steatosis. METHODS: A consecutive series of obese patients, who underwent bariatric surgery from October 2004 to May 2005, was selected. Ultrasonography was performed in all patients as part of routine preoperative time and an intraoperative wedge biopsy was obtained at the beginning of the bariatric surgery. The US and histological findings of steatosis were compared, considering histology as the gold standard. RESULTS: The study included 105 patients. The mean age was 37.2 ± 10.6 years and 75.2% were female. The histological prevalence of steatosis was 89.5%. The sensitivity and specificity of US in the diagnosis of hepatic steatosis were, respectively, 64.9% (95% CI: 54.9-74.3) and 90.9% (95% CI: 57.1-99.5). The positive predictive value and negative predictive value were, respectively, 98.4% (95% CI: 90.2-99.9) and 23.3% (95% CI: 12.3-39.0). The presence of steatosis onUS was associated to advanced grades of steatosis on histology (P = 0.016). CONCLUSION: Preoperative abdominal US in our series has not shown to be an accurate method for the diagnosis of hepatic steatosis in severe obese patients. Until another non-invasive method demonstrates better sensitivity and specificity values, histological evaluation may be recommended to these patients undergoing bariatric surgery. | Alessandro de Moura Almeida Helma Pinchemel Cotrim Daniel Batista Valente Barbosa Luciana Gordilho Matteoni de Athayde Adimeia Souza Santos Almir Galvo Vieira Bitencourt Luiz Antonio Rodrigues de Freitas Adriano Rios Erivaldo Alves | 2008 | World Journal of Gastroenterology2008，14，9： | 10 |
| 2 | Anthropometric indicators of visceral adiposity as predictors of non-alcoholic fatty liver disease: A review显示文摘The objective was to critically analyze studies that evaluated the predictive capacity of indicators of visceral adiposity in non-alcoholic fatty liver disease(NAFLD). The bibliographic research was carried out using the electronic database PubMed, LILACS and SciELO, references of selected articles. Although we found few studies, they have already used several indicators of visceral adiposity as waist circumference, waist-to-hip ratio, waist-to-height ratio, Lipid accumulation product, Body Shape Index, Body Roundness Index and most them were good predictors of NAFLD. Thus, the anthropometric indicators may contribute for the diagnosis of NAFLD in a simple, low-cost and noninvasive way, allowing early therapeutic measures to prevent the evolution to non-alcoholic steatohepatitis. | Naiade Silveira Almeida Raquel Rocha Helma Pinchemel Cotrim Carla Daltro | 2018 | World Journal of Hepatology2018，10，10： | 5 |
| 3 | Prognostic significance of vascular endothelial growth factor polymorphisms in colorectal cancer patients显示文摘AIM To investigate the associations of the genetic polymor-phisms of vascular endothelial growth factor A(VEGF-A)-1498C>T and-634G>C, with the survival of patients with colorectal cancer(CRC). METHODS A prospective cohort consisting of 131 Brazilians patients consecutively operated on with a curative intention as a result of sporadic colorectal carcinoma was studied. DNA was extracted from peripheral blood and its amplification and allelic discrimination for each genetic polymorphism was performed using the technique of polymerase chain reaction(PCR) in real-time. The real-time PCR technique was used to identify the VEGF-A-1498C>T(rs833031) and-634G>C(rs2010963) polymorphisms. Genotyping was validated for VEGF-A-1498C>T polymorphism in 129 patients and for VEGF-A-634G>C polymorphism in 118 patients. The analysis of association between categorical variables was performed using logistic regression, survival by Kaplan-Meier method and multivariate analysis by the Cox regression method. RESULTS In the univariate analysis there was a significant association(OR = 0.32; P = 0.048) between genotype CC of the VEGF-A-1498C>T polymorphism and the presence of CRC liver metastasis. There was no association between VEGF-A-1498C>T polymorphism and VEGF-A-634G>C polymorphism with further clinical or anatomopathologic variables. The genotype CC of the VEGF-A-1498C>T polymorphism was significantly correlated with the 5-year survival(P = 0.032), but not significant difference(P = 0.27) was obtained with the VEGF-A-634G>C polymorphism with the 5-year survival in the univariate analysis. The genotype CT(HR = 2.79) and CC(HR = 4.67) of the polymorphism VEGF-A-1498C>T and the genotype CC(HR = 3.76) of the polymorphism VEGF-A-634C>G acted as an independent prognostic factor for the risk of death in CRC patients. CONCLUSION The CT and CC genotypes of the VEGF-A-1498C>T and the CC genotype of the VEGF-A-634C>G polymorphisms are prognostic factors of survival in Brazilians patients with sporadic colorectal carcinoma. | Gilmar Ferreira do Espírito Santo Bianca Borsatto Galera Elisabeth Carmen Duarte Elisabeth Suchi Chen Lenuce Azis Amilcar Sabino Damazo Gabriela Tognini Saba Flávia de Sousa Gehrke Ismael Dale Cotrim Guerreiro da Silva Jaques Waisberg | 2017 | World Journal of Gastrointestinal Oncology2017，9，2： | 4 |
| 4 | Nonalcoholic fatty liver disease in asymptomatic Brazilian adolescents显示文摘AIM:To evaluate the prevalence and clinical characteristics of Nonalcoholic fatty liver disease(NAFLD) among asymptomatic Brazilian adolescents. METHODS:Transversal observational study included asymptomatic adolescents with central obesity from private and public schools in Salvador-Bahia,northeastern Brazil.The children answered a questionnaire that included age,gender,race,and medical history,and were submitted to a complete physical exam and abdominal ultrasound.Biochemical exams included:ALT,AST,GGT,C reactive protein(CRP),fasting glucose,insulin,cholesterol and triglycerides.Criteria for NAFLD included:the presence of steatosis in ultrasound and/or high level of ALT,negative or occasional historic of intake of alcohol(≤140 g/wk),negative investigation for hepatitis A,B,C,auto-immune hepatitis,Wilson disease and hemochromatosis.RESULTS:From October,2005 to October,2006,the study included 1801 subjects between 11 and 18 years of age and a mean age of 13.7±2.0 years.One hundred ninety-nine had central obesity.The prevalence of NAFLD was 2.3%,most of whom were male and white.Insulin resistance(IR)was observed in 22.9% of them and had positive correlations with ALT and GGT(P<0.05).Elevated CRP was observed in 6.9% of the cases;however,it was not associated with WC,IR or liver enzymes. CONCLUSION:The prevalence of NAFLD in Brazilian adolescents was low.The ethnicity may have influence this frequency in the population studied,which had a large proportion of African descendents. | Raquel Rocha Helma Pinchemel Cotrim Almir Galvo Vieira Bitencourt Daniel Batista Valente Barbosa Adméia Souza Santos Alessandro de Moura Almeida Bruno Cunha Isabel Guimares | 2009 | World Journal of Gastroenterology2009，15，4： | 2 |
| 5 | Sonographic hepatorenal ratio: A noninvasive method to diagnose nonalcoholic steatosis显示文摘 | Valéria Ferreira de Almeida e Borges Angélica L. D. Diniz Helma P. Cotrim Haroldo L. O. G. Rocha Nestor Barbosa Andrade | 2012 | J Clin Ultrasound2012，，1： | 2 |
| 6 | Threeeasos of preg- nancy in patients with severe pulmonary arterial hypertension: experience of a single unit 显示文摘 | Cotrim C Loureiro M J Avillez T | 2010 | Rev Port Cardiol2010，29，1： | 1 |
| 7 | Differential radiation protection of salivary glands versus tumor by Tempol with accompanying tissue assessment of Tempol by magnetic resonance imaging 显示文摘 | Cotrim AP Hyodo F Matsumoto K | 2007 | Clin Cancer Res2007，13，16： | 1 |
| 8 | Differential radiation protection of salivary glands versus tumor by Tempol with accompanying tissue assessment of Tempol by magnetic resonance imaging显示文摘 | Cotrim AP Fuminori H Ken-Ichiro M | 2007 | Clin Cancer Res2007，13，16： | 1 |
| 9 | The Developmental Competence of Oocyte, Retrieved from The Leading Follicle in Controlled Ovarian Stimulated Cycles 显示文摘 | Daniela Paes de Almeida Ferreira Braga Tatiana Carvalho de Souza Bonetti Ismael Dale Cotrim Guerreiro da Silva | 2013 | Int J Fertil Steril2013，6，4： | 1 |
| 10 | Acute resynchronization with inhaled iloprost in a pregnant woman with idiopathic pulmonary artery hypertension显示文摘 | Cotrim C Sim6es O Loureiro M J | 2006 | Rev Port Cardiol2006，25，5： | 1 |
| 11 | COL1A1 Sp1-binding site polymorphism as a risk factor for genital prolapse显示文摘 | Andrea Moura Rodrigues Manoel Jo?o Batista Castello Gir?o Ismael Dale Cotrim Guerreiro Silva Marair Gracio Ferreira Sartori Karina de Falco Martins Rodrigo de Aquino Castro | 2008 | International Urogynecology Journal2008，，11： | 1 |
| 12 | The stable nitroxide tempol facilitates salivary gland protection during head and neck irradiation in a mouse modal显示文摘 | Vitolo JM Cotrim AP Sowers AL | 2004 | Clin Cancer Res2004，10，5： | 1 |
| 13 | Three cases of pregnancy in patients with severe pulmonary arterial hypertension: experience of a single unit 显示文摘 | Cotrim S C Loureiro M J Avillez T | 2010 | Rev Port Cardiol2010，29，1： | 1 |
| 14 | Prevention of radiation-in-duced salivary hypofunction following delivery to murine sub-mandibular glands显示文摘 | Zheng C Cotrim AP Rowzee A | 2011 | Clin Cancer Res2011，17，6： | 1 |
| 15 | Transfer of the AQP1 cDNA for the correction of radiation - induced salivary hypofunction 显示文摘 | Baum BJ Zheng C Cotrim AP | 2006 | Biochim Biophys Acta2006，1758，8： | 1 |
| 16 | mTOR inhibition prevents epithelial stem cell sene- scence and protects from radiation-induced muco- sitis显示文摘 | lglesias-Bartolome R Patel V Cotrim A | 2012 | Cell Stem Cell2012，11，3： | 1 |
| 17 | Nonalcoholic fatty liver disease:clinical and histological characteristics in obese who underwent bariatric surgery显示文摘 | Bitencourt AG Cotrim HP Alves E | 2007 | Acta Gastroenterol Latinoam2007，37，4： | 1 |
| 18 | Hor- mone replacement therapy in menopausal women : risk factor or protection to nonalcoholic fatty liver disease? 显示文摘 | FLORENTINO G COTRIM HP FLORENTINOA | 2012 | Ann Hepatol2012，11，1： | 1 |
| 19 | Cyclosporin A induces proliferation in human gingival fibroblasts via induction of transforming growth factor-betal显示文摘 | Cotrim P Martelli-Junior H Graner E | 2003 | J Periodontol2003，74，11： | 1 |
| 20 | Identifying the ori- gin of lignins and monitoring their structural changes by means of FTIR - PCA and - SIMCA显示文摘 | Cotrim A R Ferraz A Gone alves A R | 1999 | Bioresource Technology1999，68，1： | 1 |
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