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31篇 您的检索式:作者名="Coumoul"
    题名 作者 年代 出处 被引量
1BRCA1 affects global DNA methylation through regulation of DNMT1显示文摘在 CpG 岛的全球 DNA hypomethylation 结合了本地 hypermethylation 是为乳癌的一个特点,然而,位于这个变化下面的机制留下逃犯。在这研究,我们证明 DNMT1,编码 methylation 维护酶,是 BRCA1 的一个 transcriptional 目标。BRCA1 通过一个潜在的 OCT1 地点和绑定绑在 DNMT1 基因的倡导者为维持 transcriptional 被要求在老鼠和人的房间的倡导者的活跃配置。我们进一步证明 BRCA1 的那损害功能在在 premaligant 阶段在一个 BRCA1 变异的老鼠模型检验的纸巾的几种类型导致全球 DNA hypomethylation,印的 genomic 的损失,和一种开的染色质配置。BRCA1 缺乏也与几 protooncogenes 的显著地增加的表达式层次被联系,包括 c-Fos,哈地岬,和 c-Myc,与在肿瘤的一个更高的表达式,当时乳房的上皮的房间显示了的 premalignant 在肿瘤和控制之间的一个中间的状态。在人的临床的样品,有 DNMT1 的减少的层次的 BRCA1 相互关联的减少的表示,和 CpG 岛的减少的 methylation。因此, BRCA1 通过断然调整 DNMT1 表示阻止全球 DNA hypomethylation,并且这为联系 BRCA1 的乳癌形成提供机制之一。Vivek Shukla Xavier Coumoul Tyler Lahusen Rui-Hong Wang Xiaoling Xu Athanassios Vassilopoulos Cuiying Xiao Mi-Hye Lee Yan-Gao Man Mutsuko Ouchi Toru Ouchi Chu-Xia Deng 2010Cell Research2010,20,11:5
2Roles of FGF receptors in mammalian development and congenital diseases显示文摘Coumoul X Deng CX 2003Birth Defects Res Part C Embryo Today2003,69,4:1
3RNAi-based conditional gene knockdown in mice using a U6 promoter driven vector 显示文摘Shukla V Coumoul X Deng CX 2007Int J Biol Sci2007,3,2:1
4Conditional knockdown of Fgfr2 in mice using Cre LoxP induced RNA interference 显示文摘Coumoul X Shukla V Li C 2005Nucleic Acids Research2005,33,11:1
5Roles of FGF receptors in mammalian development and congenital diseases显示文摘Coumoul X Deng C X 2003Birth Defects Res C Embryo Today2003,69,4:1
6Roles of FGF receptors in mammalian development and congenital diseases 显示文摘Coumoul X Deng CX 2003Birth Defects Res C Embryo Today2003,69,4:1
7Roles of FGF receptors in mammalian development and congenital diseases显示文摘 Deng CX 2003Birth Defects Res C Embryo Today2003,69,4:1
8Conditional knockdown of Fgfr2 in mice using Cre-LoxP induced RNA interference显示文摘Coumoul X Shukla V Li C 2005Nucleic Acids Res2005,33,11:1
9Roles of FGF receptors in mammalian de-velopment and congenital diseases显示文摘Coumoul X Deng C X 2003Birth Defects Res C Embryo To-day2003,69,4:1
10Inducible suppression of Fgfr2 and Survivin in ES cells using a combination of the RNA interference (RNAi) and the Cre-LoxP system显示文摘Xavier Coumoul Wenmei Li Rui-Hong Wang 2004Nucleic Acids Research2004,32,10:1
11Inducible suppression of Fgfr2 and Survivin in KS cells using a combination of the RNA interference (RNAi) and the Cre-LoxP system显示文摘Coumoul X Li W Wang RH 2004Nucleic Acids Res2004,32,10:1
12RNAi in mice: a promising appr-oach to decipher gene functions in vivo 显示文摘Coumoul X Deng CX 2006Biochimie2006,88,6:1
13PXR-dependent induction of human CYP 3A4 gene expression by organo-chlorine pesticides显示文摘XAVIER COUMOUL MONIQUE DIRY ROBERT BAROUKI 2002Biochemical Pharma-cology2002,64,10:1
14Roles of FGF receptors in mammalian development and congenital diseases显示文摘Coumoul X Deng C X 2003Birth Defects Res C Embryo Today2003,69,4:1
15Conditional knockdown of Fgfr2 in mice using Cre-LoxP induced RNA interference 显示文摘Coumoul X Shukla V Li C L 2005Nucleic Acids Research2005,33,11:1
16Differential regulation of cytochrome P450 1A1 and 1B1 by a combination of dioxin and pesticides in the breast tumor cell line MCF-7显示文摘Coumoul X Diry M Robillot C 2001Cancer Res2001,61,10:1
17Roles of FGF receptors in mammalian development and congenital diseases显示文摘Coumoul X Deng CX 0,,:1
18Activation of the dioxin/aryl hydrocarbon receptor (AhR) modulates cell plasticity through a JNK-dependent mechanism 显示文摘Diry M Tomkiewicz C Koehle C Coumoul X Bock KW Barouki R 2006Oncogene2006,25,40:1
19Roles of FGF receptors in mammalian development and congenital diseases 显示文摘Coumoul X Deng C X 2003Birth Defects Res Part C Embryo Today2003,69,:1
20Inducible suppression of Fgfr2 and Survivin in ES cells using a combination of the RNA interference (RNAi) and the Cre-LoxP system显示文摘 Li W Wang RH 2004Nucleic Acids Res2004,32,10:1
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