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| 1 | QRISK(一种适用于英国的新型心血管疾病风险评分)的建立与验证:前瞻性开放性队列研究显示文摘目的:建立一种适用于英国的新型心血管风险评分(QRISK)模型,并验证其相对于已确立的Framingham心血管疾病评估系统及新近建立的Scottish评分(ASSIGN)的效能。设计:利用自全科诊所常规收集的数据进行前瞻性开放性队列研究。地点:将数据归纳入QRESEARCH数据库的英国诊所。 | Hippisley- Cox J. Coupland C. Vinogradova Y. 罗亮 | 2007 | 世界核心医学期刊文摘(心脏病学分册)2007，，12： | 11 |
| 2 | 20~64岁人群的抗抑郁药使用和心血管结局风险:初级医疗数据库的队列研究显示文摘目的探讨抑郁患者不同抗抑郁治疗方案与3种心血管结局(心肌梗死、中风或短暂性脑缺血发作、心律不齐)比率的关系。设计队列研究。场所为 QResearch 初级医疗数据库贡献数据的英国全科诊所。参与者2000-01-01至2011-07-31首次诊断为抑郁症的年龄为20~64岁的238963例患者。干预抗抑郁药(三环类及相关抗抑郁药、选择性5-羟色胺再摄取抑制剂、其他抗抑郁药)、剂量、使用时间、个体化抗抑郁药。主要结局指标5年随访过程中心肌梗死、中风或短暂性脑缺血发作、心律不齐的首次确诊。采用 Cox 比例风险回归模型估计风险比例,调整潜在混杂变量。结果5年随访期间,772例患者发生心肌梗死,1106例患者发生中风或短暂性脑缺血发作,1452例患者发生心律不齐。未发现抗抑郁药与心肌梗死存在显著关联。随访第1年,使用选择性5-羟色胺再摄取抑制剂患者与未使用选择性5-羟色胺再摄取抑制剂患者相比,心肌梗死风险明显下降〔 HR'=0.58,95% CI (0.42,0.79)〕;在个体化抗抑郁药中,氟西汀能够大幅降低心肌梗死风险〔HR'=0.44,95% CI(0.27,0.72)〕,而洛非帕明则会大幅增加心肌梗死风险〔HR'=3.07,95% CI(1.50,6.26)〕。抗抑郁药或个体化抗抑郁药与中风或短暂性脑缺血发作风险无明显关联。5年随访期间,抗抑郁药与心律失常无明显关联,但是在三环类及相关抗抑郁药治疗期间的前28 d 风险大幅上升〔HR'=1.99,95% CI(1.27,3.13)〕。5年随访期间,氟西汀大幅降低心律不齐的风险〔HR'=0.74,95% CI(0.59,0.92)〕,但是,即使采用高剂量,西酞普兰与心律不齐风险仍无明显关联〔 HR'=1.11,95% CI(0.72,1.71),剂量≥40 mg/ d)。结论选择性5-羟色胺再摄取抑制剂不会增加20~64岁抑郁患者的心律不齐或中风或短暂性脑缺血发作风险,而西酞普兰也不会增加心律不齐风险。选择性5-羟色胺再摄取抑制剂可能会降低心肌梗死风险,尤其是氟西汀,而洛非帕明会增加心肌梗死风险。 | Coupland C Hill T Morriss R 本刊编辑部 | 2016 | 中国全科医学2016，19，15： | 7 |
| 3 | Small Ubiquitin-Like Modifier Conjugating Enzyme with Active Site Mutation Acts as Dominant Negative Inhibitor of SUMO Conjugation in Arabidopsis显示文摘Small ubiquitin-like modifier (SUMO) conjugation affects a broad range of processes in plants, including growth, flower initiation, pathogen defense, and responses to abiotic stress. Here, we investigate in vivo and in vitro a SUMO conjugating enzyme with a Cys to Ser change in the active site, and show that it has a dominant negative effect. In planta expression significantly perturbs normal development, leading to growth retardation, early flowering and gene expression changes. We suggest that the mutant protein can serve as a probe to investigate sumoylation, also in plants for which poor genetic infrastructure precludes analysis via loss-of-function mutants. | Konstantin Tomanov Christian Hardtke Ruchika Budhiraja Rebecca Hermkes George Coupland Andreas Bachmair | 2013 | Journal of Integrative Plant Biology2013，55，1： | 4 |
| 4 | Differences in outcomes of oesophageal and gastric cancer surgery across Europe显示文摘 | J. L. Dikken J. W. van Sandick W. H. Allum J. Johansson L. S. Jensen H. Putter V. H. Coupland M. W. J. M. Wouters V. E. P. Lemmens C. J. H. van de Velde | 2012 | Br J Surg2012，，1： | 4 |
| 5 | 用DTL电极测量我国正常人视网膜电图的明视负波反应显示文摘目的用DTL电极测量我国正常人视网膜电图的明视负波反应(PhNR)的正常值,探讨正常人PhNR的特征。方法应用美国ESPION视觉电生理仪及一次性使用的DTL电极测量我国正常人65例(112眼)的PhNR。全视野刺激器由LED发出光源,选用蓝色背景光(亮度为10cd/m2),刺激光为红色(刺激光强度分别为1、5cd.s/m2和7cd.s/m2)。按10岁一年龄组分组统计PhNR的振幅和潜伏期。结果经统计学分析,将年龄组间无显著统计学差异的组作合并后,分成<50岁和≥50岁两个年龄组。这两组的正常振幅值在1、5cd.s/m2和7cd.s/m2时分别为(-38.94±10.21)μV和(-32.41±7.76)μV,(-38.51±10.97)μV和(-34.52±8.90)μV,(-38.62±9.98)μV和(-33.96±9.81)μV,正常潜伏值分别为(65.83±4.06)ms和(69.86±5.68)ms,(66.17±6.48)ms和(71.33±4.90)ms,(65.81±6.71)ms和(70.40±4.61)ms,表明两个年龄组的振幅和潜伏值均有显著统计学差异。结论一次性DTL电极可防止交叉感染。研究确定了按相关年龄分组的我国正常人PhNR的正常值。 | 李明翰 吴德正 Stuart G Coupland 龙时先 梁炯基 | 2006 | 眼科研究2006，24，2： | 3 |
| 6 | SnapShot: Control of Flowering in Arabidopsis显示文摘 | Fabio Fornara Amaury de Montaigu George Coupland | 2010 | Cell2010，，3： | 2 |
| 7 | The CONSTANS gene of arabidopsis promotes flowering and encodes a protein showing similarities to zinc finger transcription factors显示文摘 | Joanna Putterill Frances Robson Karen Lee Rüdiger Simon George Coupland | 1995 | Cell1995，，6： | 2 |
| 8 | Decreased prefrontal myo-inositol in major depressive disorder 显示文摘 | Coupland NJ Ogilvie C J Hegadoren KM | 2005 | Biol Psychiat2005，57，： | 1 |
| 9 | Intestinal trehalase activity in a UK population: establishing a normal range and the effect disease显示文摘 | Murray IA Coupland K Smith JA | 2000 | Br J Nutr2000，83，3： | 1 |
| 10 | Primary pericardial synovial sarcoma:a case report and literature review显示文摘 | Al-Rajhi N Husain S Coupland R | 1999 | J Surg Oncol1999，70，3： | 1 |
| 11 | Practical dihydroxylation and C-C cleavage of unsaturated fatty acids显示文摘 | Oakley M A Woodward S Coupland K | 1999 | J Mol Catal A:Chem1999，150，： | 1 |
| 12 | Trends in incidence of small cell lung cancer and all lung cancer显示文摘 | RIAZ S P LuCHTENBORG M COUPLAND V H | 2012 | Lung cancer2012，75，3： | 1 |
| 13 | Differential expression of matrix metalloproteinases and their tissue inhibitors in colon mucosa of patients with inflammatory bowel disease显示文摘 | B von Lampe B Barthel S E Coupland | 2000 | Gut2000，47，1： | 1 |
| 14 | Time and deprivation trends in incidence of primary liver cancer subtypes in England 显示文摘 | Konfortion J Coupland V H Kocher H M | 2014 | Journal of evaluation in clinical practice2014，20，4： | 1 |
| 15 | A tale of three next generation sequencing platforms: comparison of Ion Torrent, Pacific Biosciences and Illumina MiSeq sequencers显示文摘 | QUALI M A SMITH M COUPLAND P | 2012 | BMC Ge- nomics2012，13，1： | 1 |
| 16 | Expectations, experiences, and psychological outcomes of childbirth: A prospective study of 825 women显示文摘 | Green JM Coupland VA Kitzinger JV | 1990 | Birth1990，17，： | 1 |
| 17 | Corporate social responsibility as argument on the web 显示文摘 | Coupland C | 2005 | Journal of Business Ethics2005，62，： | 1 |
| 18 | The effect of surfactants on the solubility, zeta potential, and viscosity of soy protein isolates 显示文摘 | Malhotra A Coupland J N | 2004 | Food Hydrocolloids2004，18，1： | 1 |
| 19 | Response of plant development to environment control of flowering by daylength and temperature显示文摘 | Reeves P H Coupland G | 2000 | Curr Opin Plant Biol2000，3，： | 1 |
| 20 | The molecular basis of diversity in the photoperiodic flowering responses of Arabidopsis and rice显示文摘 | HAYAMA R COUPLAND G | 2004 | Plant Physiology2004，135，： | 1 |
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