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| 1 | Hepatic steatosis and fibrosis: Non-invasive assessment显示文摘Chronic liver disease is a major cause of morbidity and mortality worldwide and usually develops over many years, as a result of chronic inflammation and scarring, resulting in end-stage liver disease and its complications. The progression of disease is characterised by ongoing inflammation and consequent fibrosis, although hepatic steatosis is increasingly being recognised as an important pathological feature of disease, rather than being simply an innocent bystander. However, the current gold standard method of quantifying and staging liver disease, histological analysis by liver biopsy, has several limitations and can have associated morbidity and even mortality. Therefore, there is a clear need for safe and noninvasive assessment modalities to determine hepatic steatosis, inflammation and fibrosis. This review covers key mechanisms and the importance of fibrosis and steatosis in the progression of liver disease. We address non-invasive imaging and blood biomarker assessments that can be used as an alternative to information gained on liver biopsy. | Rustam N Karanjia Mary ME Crossey I Jane Cox Haddy KS Fye Ramou Njie Robert D Goldin Simon D Taylor-Robinson | 2016 | World Journal of Gastroenterology2016，22，45： | 6 |
| 2 | Urinary nuclear magnetic resonance spectroscopy of a Bangladeshi cohort with hepatitis-B hepatocellular carcinoma: A biomarker corroboration study显示文摘AIM: To establish if a distinct urinary metabolic profile could be identified in Bangladeshi hepatitis-B hepatocellular carcinoma(HCC) patients compared to cirrhosis patients and controls. METHODS: Urine samples from 42 Bangladeshi patients with HCC(39 patients with hepatitis-B HCC), 47 with cirrhosis on a background of hepatitis B, 46 with chronic hepatitis B, and seven ethnically-matched healthy controls were analyzed using nuclear magnetic resonance(NMR) spectroscopy. A full dietary and medication history was recorded for each subject. The urinary NMR data were analyzed using principal component analysis(PCA) and orthogonal partial leastsquared discriminant analysis(OPLS-DA) techniques. Differences in relative signal levels of the most discriminatory metabolites identified by PCA and OPLSDA were compared between subject groups using an independent samples Kruskal-Wallis one-way analysis of variance(ANOVA) test with all pairwise multiple comparisons. Within the patient subgroups, the MannWhitney U test was used to compare metabolite levels depending on hepatitis B e-antigen(HBe Ag) status and treatment with anti-viral therapy. A BenjaminiHochberg adjustment was applied to acquire the level of significance for multiple testing, with a declared level of statistical significance of P < 0.05.RESULTS: There were significant differences in age(P < 0.001), weight(P < 0.001), and body mass index(P < 0.001) across the four clinical subgroups. Serum alanine aminotransferase(ALT) was significantly higher in the HCC group compared to controls(P < 0.001); serum α-fetoprotein was generally markedly elevated in HCC compared to controls; and serum creatinine levels were significantly reduced in the HCC group compared to the cirrhosis group(P = 0.004). A threefactor PCA scores plot showed clustering of the urinary NMR spectra from the four subgroups. Metabolites that contributed to the discrimination between the subgroups included acetate, creatine, creatinine, dimethyamine(DMA), formate, glycine, hippurate, and trimethylamine-N-oxide(TMAO). A comparison of relative metabolite levels confirmed that carnitine was significantly increased in HCC; and creatinine, hippurate, and TMAO were significantly reduced in HCC compared to the other subgroups. HBe Ag negative patients showed a significant increase in creatinine(P = 0.001) compared to HBe Ag positive patients in the chronic hepatitis B subgroup, whilst HBe Ag negative patients showed a significant decrease in DMA(P = 0.004) in the cirrhosis subgroup compared to HBe Ag positive patients. There were no differences in metabolite levels in HCC patients who did or did not receive antiviral treatment. CONCLUSION: Urinary NMR changes in Bangladeshi HCC were identified, corroborating previous findings from Egypt and West Africa. These findings could form the basis for the development of a cost-effective HCC dipstick screening test. | I Jane Cox Abil E Aliev Mary ME Crossey Mahvish Dawood Mamun Al-Mahtab Sheikh M Akbar Salimur Rahman Antonio Riva Roger Williams Simon D Taylor-Robinson | 2016 | World Journal of Gastroenterology2016，22，16： | 4 |
| 3 | Mating-type-specific and nonspecific PAK kinases play shared and divergent role in cytokinesis,differentiation and virulence of Cryptococcus neoformans显示文摘 | Wang P Nichols CS Lengeler KB Cardenas ME Cox GM Perfect JR Heitman J | 2002 | Eukaryot Cell2002，1，2： | 1 |
| 4 | Insulin receptor expression by human prostate cancers显示文摘 | Cox ME Gleave ME Zakikhani M | 2009 | Prostate2009，69，1： | 1 |
| 5 | Relationship be- tween quality of life and clinical status in asthma:a factor analysis 显示文摘 | Juniper EF Wisniewski ME Cox FM | 2004 | Eur RespirJf2004，23，2： | 1 |
| 6 | Transforming growth factor beta 1 and renal injury following subtotal nephrectomy in the rat: role of the renin-angiotensin system显示文摘 | Cox A Roe CJ Dziadek M Cooper ME | 1997 | Kidney Int1997，51，5： | 1 |
| 7 | Aminoguanidine ameliorates overexpression of prosclerotic growth factors and collagen deposition in experimental diabetic nephropathy显示文摘 | Kelly DJ Gilbert RE Cox AJ Soulis T Jerums G Cooper ME | 2001 | J Am Soc Nephrol2001，12，： | 1 |
| 8 | Nursing identification of de- lirium显示文摘 | Flagg B Cox L Me Dowell S | 2010 | Clin Nurse Spec2010，24，5： | 1 |
| 9 | Effects of age and human papilloma viral load on colposcopy triage:data from the randomized atypical squamous cells of undetermined significance /low grade squamous intraepithelial lesion triage study显示文摘 | Sherman ME Schiffman M Cox JT | 2002 | J Natl Cancer Inst2002，94，2： | 1 |
| 10 | Habitat segregation of dengue vectors along an urban environmental gradient显示文摘 | Cox J GriUet ME Ramos OM | 2007 | Am J Trop Med Hyg2007，76，5： | 1 |
| 11 | Dipeptidyl peptidase -4 in- hibitors in the management of type 2 diabetes : safety, tolerability, and efficacy显示文摘 | Cox ME Rowell J Corsino L | 2010 | Drug Heahhc Patient Saf2010，2，： | 1 |
| 12 | Effect of age and human papilloma viral load on colposcopy triage:Data from the randomized atypical squamous cells of undertermined significance/low-Grade squamous intraepithelial lesion triage study(ALTS)显示文摘 | Sherman ME Schiffman M Cox JT | 2002 | J Natl Cancer Inst2002，94，： | 1 |
| 13 | Dipeptidyl peptidase-4 inhibitors in the management of type 2 diabetes: safety, tolerability, and efficacy显示文摘 | Cox ME Rowell J Corsino L | 2010 | Drug Healthc Patient Saf2010，2，： | 1 |
| 14 | Toxicity of local anaesthetics 显示文摘 | Cox B Durieux ME Marcus MA | 2003 | Best Pract Res Clin Anaesthesiol2003，17，1： | 1 |
| 15 | Acquisition of neuro- endocrine characteristics by prostate tumor cells is reversible: implications for prostate cancer progression显示文摘 | Cox ME Deeble PD Lakhani S | 1999 | Cancer Res1999，59，15： | 1 |
| 16 | Adverse drug events during AKIand its recovery显示文摘 | Cox ZL Mc Coy AB Matheny ME | 2013 | Clin J Am Soc Nephrol2013，8，7： | 1 |
| 17 | Relationship between quality of life and clinical status in asthma:a factor analysis显示文摘 | Juniper EF Wisniewski ME Cox FM | 2004 | Eur Respir J2004，23，2： | 1 |
| 18 | Toxicity of local anaesthetics显示文摘 | Cox B Durieux ME Marcus MA | 2003 | Best Pract Res Clin Anaesthesiol2003，17，1： | 1 |
| 19 | Activated 3',5'-cyclic AMP-dependent protein kinase is sufficient to induce neuroendocrine-like differentiation of the LNCaP prostate tumor cell line显示文摘 | Cox ME Deeble PD Bissonette EA | 2000 | Biol Chem2000，275，13： | 1 |
| 20 | Effects of age and human papilloma viral load on colposcopy triage :data from the randomized atypical squamous cells of undetermined significance/lowgrade squamous intraepithelial lesion triage study 显示文摘 | Sherman ME Schiffman M Cox JT | 2002 | J Natl Cancer Inst2002，94，2： | 1 |
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