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| 1 | GRADE指南:Ⅵ.证据质量评价--不精确性(随机误差)显示文摘GRADE建议通过检查95%可信区间(CI)为决定不精确性的最佳方法。在指南实际运用中,如果CI的上、下限值代表了真实效应,而临床实际情况与之不符时,必须降低证据质量级别(即对效应估计值的把握度)。除外当效应值很大且可信区间提示效应稳健,而总样本量不大且事件数很少的情况,其他应考虑因不精确性而降低证据质量级别。作此决定时,可计算有足够检验效能的单个试验所需的病例数(定义为'最优信息样本量',即optimal information size,OIS)。对连续型变量,我们建议用类似方法,首先考虑可信区间上、下限值,再计算OIS。系统评价(SR)所需方法略有不同。如果95%CI不包括相对危险度(RR)为1,且总事件发生数或病例数超过OIS标准,则精确性良好。如果95%CI包括了明显获益或危害(我们建议以RR值<0.75或>1.25作粗标准),即使达到OIS要求,因不精确性而降低证据质量级别较恰当。 | Gordon Guyatt Andrew D.Oxman Regina Kunz Jan Brozek Pablo Alonso-Coello David Rind PJ Devereaux Victor M.Montori Bo Freyschuss Gunn Vist Roman Jaeschke John W.Williams Jr. Mohammad Hassan Murad David Sinclairk Yngve Falck-Ytter Joerg Meerpohl Craig Whittington Kristian orlund Je Andrews Holger J.Schünemann 代表GRADE工作组 李幼平 王莉 陈尹 高霑 | 2011 | 中国循证医学杂志2011，11，12： | 43 |
| 2 | Analysis of optineurin (OPTN) gene mutations in subjects with and without glaucoma: the Blue Mountains Eye Study显示文摘 | Baird PN Richardson AJ Craig JE | 2004 | Clin Experiment Ophthalmol2004，32，： | 1 |
| 3 | Cigarette smoking and serum lipid and lipoprotein concentrations: an analysis of published data 显示文摘 | Craig M Palomaki GE Haddow JE | 1989 | BMJ1989，298，6676： | 1 |
| 4 | Mechanism of topiramate-in-duced acute-onset myopia and angle closure glaucoma 显示文摘 | Craig JE Ong TJ Louis DL | 2004 | AmJ Ophthalmol2004，137，1： | 1 |
| 5 | Retinopathy of prematurity:recent advances in our understanding显示文摘 | Wheatley CM Dickinson JL Mackey DA Craig JE Sale MM | 2002 | Br J Ophthalmol2002，86，： | 1 |
| 6 | Amiodarone is safe and highly effective therapy for supraventricular tachycardia in infants显示文摘 | Etheridge SP Craig JE Compton SJ | 2001 | Am Heart J2001，141，1： | 1 |
| 7 | Rapid detection of deletions causing delta beta thalassemia and heredi- tary persistence of fetal hemoglobin by enzymatic am- plification显示文摘 | Craig JE Bametson RA Prior J | 1994 | Blood1994，83，6： | 1 |
| 8 | The optics of aircraft shearflows显示文摘 | ROSEWC | 1985 | AIAA1985，12，14： | 1 |
| 9 | Aetiology of congenital and pediatric cataract in an Australian population 显示文摘 | Wirth MG Russel-Eggitt IM Craig JE | 2002 | Br J Ophthalmol2002，6，： | 1 |
| 10 | Major fetal abnormalities associated with positive screening tests for Smith-Lemli-Opitz syndrome (SLOS) 显示文摘 | Craig WY Haddow JE Palomaki GE | 2007 | Prenat Diagn2007，27，5： | 1 |
| 11 | Cigaretle smoking and serum lipid and lipoprotein concentrations ananalysis of published data EJJ 显示文摘 | Craig WY Palomaki GE Haddow JE | 1989 | BMJ1989，298，： | 1 |
| 12 | Lipoprotei(a)levels in peripherl atherosclerotic disease显示文摘 | Craig WY Kloza EM Haddow JE | 1995 | Vase Sury1995，21，3： | 1 |
| 13 | Aetiology of congenital and paediatric cataract in an Australian population显示文摘 | Wirth MG Russell-Eggitt IM Craig JE | 2002 | Br J Ophthalmol2002，86，： | 1 |
| 14 | Retinopathy of prematurity: recent advances in our understanding显示文摘 | Dickinson JL Mackey DA Craig JE Sale MM | 2002 | BrJ Ophthalmol2002，86，6： | 1 |
| 15 | Chronic moniliasis associated with Addison's disease显示文摘 | Craig JM Schiff LH Boone JE | 1955 | AMA Am J Dis Child1955，89，6： | 1 |
| 16 | Genetic factors in athetoid cerebral palsy 显示文摘 | Amor DJ Craig JE Delatycki MB | 2001 | J Child Neurol2001，16，11： | 1 |
| 17 | Dissecting the loci controlling fetal haemoglobin production on chromosones 11 p and 6q by the regressive approach 显示文摘 | Craig JE Rochette J Fisher CA | 1996 | Nat Genet1996，12，1： | 1 |
| 18 | Cigarette smoking and serum lipid and lipoprotein concentrations: an analysis of published data显示文摘 | Craig WY Palomaki GE Haddow JE | 1989 | BMJ1989，298，： | 1 |
| 19 | Attitudes to predictive DNA testing for myocilin glaucoma:experience with a large Australian family显示文摘 | Healey DL Craig JE Wilkinson CH | 2004 | J Glaucoma2004，13，： | 1 |
| 20 | Detection,screening and community epidemiology of taenia cestode zoonosis:cystic echinococcosis,alvedar echinococcosis and neurocysticercosis显示文摘 | Craig PS Rogan MT Allan JE | 1996 | Adv Parasitol1996，138，9： | 1 |
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