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| 1 | Using induced pluripotent stem cells as a tool for modelling carcinogenesis显示文摘Cancer is a highly heterogeneous group of diseases that despite improved treatments remain prevalent accounting for over 14 million new cases and 8.2 million deaths per year. Studies into the process of carcinogenesis are limited by lack of appropriate models for the development and pathogenesis of the disease based on human tissues. Primary culture of patient samples can help but is difficult to grow for a number of tissues. A potential opportunity to overcome these barriers is based on the landmark study by Yamanaka which demonstrated the ability of four factors;Oct4, Sox2, Klf4, and c-Myc to reprogram human somatic cells in to pluripotency. These cells were termed induced pluripotent stem cells(i PSCs) and display characteristic properties of embryonic stem cells. This technique has a wide range of potential uses including disease modelling, drug testing and transplantation studies. Interestingly i PSCs also share a number of characteristics with cancer cells including self-renewal and proliferation, expression of stem cell markers and altered metabolism. Recently, i PSCs have been generated from a number of human cancer cell lines and primary tumour samples from a range of cancers in an attempt to recapitulate the development of cancer and interrogate the underlying mechanisms involved. This review will outline the similarities between the reprogramming process and carcinogenesis, and how these similarities have been exploited to generate i PSC models for a number of cancers. | Emma L Curry Mohammad Moad Craig N Robson Rakesh Heer | 2015 | World Journal of Stem Cells2015，7，2： | 5 |
| 2 | Invasive Pneumococcal Disease in Children 5 Years After Conjugate Vaccine Introduction - Eight States, 1998-2005显示文摘 | Reingold A Hadler J Farley M M Harrison L Lynfield R Lexau C Bennett N Thomas A Craig A S Smith P J Beall B Whitney C G Moore M Pilishvili T | 2008 | MMWR Morbidity and Mortality Weekly Report2008，，6： | 1 |
| 3 | CFD simulation of anaerobic digester with variable sewage sludge rheology显示文摘 | CRAIG K J NIEUWOUDT M N NIEMAND L J | 2013 | Water Research2013，47，13： | 1 |
| 4 | Electrochemical principles for active control of liquids on submillimeter scales显示文摘 | Gallardo B S Gupta V K Eagerton F D Jong L I Craig V S Shah R R Abbott N L | 1999 | Science1999，283，： | 1 |
| 5 | Replacement of fish meal in cobia (Rachycentron canadum) diets using an organically certified protein 显示文摘 | Angela N L Craig S R McLean E | 2006 | Aquaculture2006，257，： | 1 |
| 6 | Hydrocyclone separation of dry-milled com 显示文摘 | Dickey L C Dallmer M F Radewonuk E R Parris N Kurantz M and Craig J C | 1997 | Cereal Chem1997，74，3： | 1 |
| 7 | Wear Behavior of Lubricant - Conditioned Copper Rails and Armatures in a Railgun显示文摘 | Irwin L Singer Michael J Veracka Craig N Boyer and Jesse M Neri | 2011 | IEEE Transactions On Plasma Science2011，39，1： | 1 |
| 8 | In vitro Tn7 nmtagenesis of Haemophilus influenzae Rd and characterization of the role of atpA in transformation 显示文摘 | Gwinn M L Stellw~igen A E Craig N L | 1997 | J Bacteriol1997，179，： | 1 |
| 9 | Performance of a wind turbine connected to a weak rural network显示文摘 | Craig L M Jenkins N | 1995 | Wind Engineering1995，19，3： | 1 |
| 10 | Functional characterization of an active Rag-like transposase显示文摘 | Hencken C G Li X Craig N L | 2012 | Nat Struct Mol Biol2012，19，8： | 1 |
| 11 | piggyBac can bypass DNAsynthesis during cut and paste transposition显示文摘 | Mitra R Fain-Thornton J Craig N L | 2008 | EMBO J2008，27，7： | 1 |
| 12 | Plant density modifies within canopy cotton fiber quality显示文摘 | CRAIG W B Robert L N Steve M B | 2006 | Crop Science2006，2，24： | 1 |
| 13 | Ultrastructural analysis of human T and TC mast cells identified by immunoelectron microscopy显示文摘 | Craig S S Schechter N M Schwartz L B | 1988 | Lab Invest1988，58，6： | 1 |
| 14 | A large focus of alveolar echinococcosis in central China显示文摘 | Craig P S Liu D Macpherson C N L | 1992 | Lancet1992，340，： | 1 |
| 15 | Replacement of fish meal in cobia (Rachycentron canadum)diets using an organically certified protein显示文摘 | ANGELA N L CRAIG S R MCLEAN E | 2006 | Aquaculture2006，257，1234： | 1 |
| 16 | The effects of organic protein supplementation upon growth,feed conversion and texture quality parameters of juvenile cobia (Rachycentron canadum)显示文摘 | ANGELA N L MCLEAN E CRAIG S R | 2007 | Aquaculture2007，264，1234： | 1 |
| 17 | Estimating the cost of exWacting cereal protein with ethanol 显示文摘 | Dickey L C McAloon A Craig J C Parris N | 1999 | Industrial Crops and Products1999，10，： | 1 |
| 18 | Three axis strainand temperature fiber optic grating sensor 显示文摘 | DREW N CRAIG L | 1996 | SPIE1996，2718，2628： | 1 |
| 19 | Processing of C3b-opsonized immune complexes bound to non-complement receptor1(CR1) sites on red cells:phagocytosis,transfer,and associations with CR1显示文摘 | Craig M L Waitumb J N Taylor R P | 2005 | J Immunol2005，174，5： | 1 |
| 20 | Ultrastruc-tural analysis of human T and TC mast cell indenti-fied by immunoelectron microscopy 显示文摘 | Craig S S Schechter N Schwartz L B | 1988 | Lab Invest1988，58，： | 1 |
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