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| 1 | Acoustic radiation force imaging sonoelastography for noninvasive staging of liver fibrosis显示文摘AIM:To investigate the diagnostic accuracy of acoustic radiation force impulse (ARFI) imaging as a noninvasive method for the assessment of liver fibrosis in chronic hepatitis C (CHC) patients.METHODS:We performed a prospective blind com-parison of ARFI elastography,APRI index and FibroMax in a consecutive series of patients who underwent liver biopsy for CHC in University Hospital Bucharest. His-topathological staging of liver fibrosis according to the METAVIR scoring system served as the reference. A to-tal of 74 patients underwent ARFI elastography,APRI index,FibroMax and successful liver biopsy. RESULTS:The noninvasive tests had a good correlation with the liver biopsy results. The most powerful test in predicting fibrosis was ARFI elastography. The diagnostic accuracy of ARFI elastography,expressedas area under receiver operating characteristic curve (AUROC) had a validity of 90.2% (95% CI AUROC = 0.831-0.972,P < 0.001) for the diagnosis of significant f ibrosis (F ≥ 2). ARFI sonoelastography predicted even better F3 or F4 fibrosis (AUROC = 0.993,95% CI = 0.979-1).CONCLUSION:ARFI elastography had very good accuracy for the assessment of liver fibrosis and was superior to other noninvasive methods (APRI Index,FibroMax) for staging liver fibrosis. | Carmen Fierbinteanu-Braticevici Dan Andronescu Radu Usvat Dragos Cretoiu Cristian Baicus Gabriela Marinoschi | 2009 | World Journal of Gastroenterology2009，15，44： | 114 |
| 2 | Cellular and molecular basis of chronic constipation: Taking the functional/idiopathic label out显示文摘In recent years, the improvement of technology and the increase in knowledge have shifted several strongly held paradigms. This is particularly true in gastroenterology, and specifically in the field of the so-called 'functional' or 'idiopathic' disease, where conditions thought for decades to be based mainly on alterations of visceral perception or aberrant psychosomatic mechanisms have, in fact, be reconducted to an organic basis (or, at the very least, have shown one or more demonstrable abnormalities). This is particularly true, for instance, for irritable bowel syndrome, the prototype entity of 'functional' gastrointestinal disorders, where low-grade inflammation of both mucosa and myenteric plexus has been repeatedly demonstrated. Thus, researchers have also investigated other functional/idiopathic gastrointestinal disorders, and found that some organic ground is present, such as abnormal neurotransmission and myenteric plexitis in esophageal achalasia and mucosal immune activation and mild eosinophilia in functional dyspepsia. Here we show evidence, based on our own and other authors' work, that chronic constipation has several abnormalities reconductable to alterations in the enteric nervous system, abnormalities mainly characterized by a constant decrease of enteric glial cells and interstitial cells of Cajal (and, sometimes, of enteric neurons). Thus, we feel that (at least some forms of) chronic constipation should no more be considered as a functional/idiopathic gastrointestinal disorder, but instead as a true enteric neuropathic abnormality. | Gabrio Bassotti Vincenzo Villanacci Dragos Cretoiu Sanda Maria Cretoiu Gabriel Becheanu | 2013 | World Journal of Gastroenterology2013，19，26： | 9 |
| 3 | Exercise-mediated regulation of autophagy in the cardiovascular system显示文摘Cardiovascular disease is the leading cause of human death worldwide. Autophagy is an evolutionarily conserved degradation pathway,which is a highly conserved cellular degradation process in which lysosomes decompose their own organelles and recycle the resulting macromolecules.Autophagy is critical in maintaining cardiovascular homeostasis and function, and excessive or insufficient autophagy or autophagic flux can lead to cardiovascular disease. Enormous evidence indicates that exercise training plays a beneficial role in the prevention and treatment of cardiovascular diseases. The regulation of autophagy during exercise is a bidirectional process. For cardiovascular disease caused by either insufficient or excessive autophagy, exercise training restores normal autophagy function and delays the progression of cardiovascular disease.An in-depth exploration and discussion of exercise-mediated regulation of autophagy in the cardiovascular system can broaden our view about the prevention of various autophagy-related diseases through exercise training. In this article, we review autophagy and its related signaling pathways,as well as autophagy-dependent beneficial effects of exercise in cardiovascular system. | Lijun Wang Jiaqi Wang Dragos Cretoiu Guoping Li Junjie Xiao | 2020 | Journal of Sport and Health Science2020，9，3： | 3 |
| 4 | 应用GT-Styrene~苯乙烯回收技术对裂解汽油的改质分析显示文摘通过采用GT-Styrene苯乙烯回收技术对传统的裂解汽油处理工艺进行改进,汽油的产品性能可以得到有效的改善,并回收有价值的苯乙烯产品和得到高质量的混合二甲苯产品。 | 于婷婷 安晓冬 吴兴松 Cimpeanu Andrei Cretoiu Mircea | 2011 | 乙烯工业2011，23，2： | 2 |
| 5 | Molecular characterization of invasive and non-invasive Streptococcus pyogenes isolates from Romania显示文摘 | Luca-Harari B Straut M Cretoiu S | | 0，，11： | 1 |
| 6 | Interstitial Cajal-like cells (ICLC) as steroid hormone sensors in human myometrium:immunocytochemical approach显示文摘 | Cretoiu D Ciontea SM Popescu LM | 2006 | J Cell Mol Med2006，10，3： | 1 |
| 7 | Molecular characterization of invasive and non-invasive Streptococcus pyogenes isolates from Romania显示文摘 | Luca-Harari B Straut M Cretoiu S | 2008 | J Med Microbiol2008，57，11： | 1 |
| 8 | Molecular characterization of invasive and non-invasive Streptococcus pyogenes isolates from Romania显示文摘 | Luca-Harari B Straut M Cretoiu S | 2008 | J Med Microbiol2008，57，11： | 1 |
| 9 | Interstitial Cajal-like cells of human Fallopian tube express estrogen and progesterone receptors显示文摘 | Sanda Maria Cretoiu D. Cretoiu Laura Suciu L. M. Popescu | 2009 | Journal of Molecular Histology (-)2009，，5： | 1 |
| 10 | Novel type of interstitial cell (Cajallike) in human fallopian tube显示文摘 | Popescu LM Ciontea SM Cretoiu D | | 0，，： | 1 |
| 11 | Interstitial Cajal-like cells in human uterus and fallopian tube显示文摘 | POPESCU L M CIONTEA S M CRETOIU D | 2007 | Ann N Y Acad Sci2007，1101，： | 1 |
| 12 | Interstitial Cajal-like cells in human uterus and fallopian tube显示文摘 | Popescu LM Ciontea SM Cretoiu D | | 0，，： | 1 |
| 13 | Novel type of interstitial cell (Cajal-like)in human fallopian tube显示文摘 | POPESCU LM CIONTEA SM CRETOIU D | 2005 | J Cell Mol Med2005，9，： | 1 |
| 14 | The great screen anomaly a new frontier in product discovery through functional metage- nomics显示文摘 | EKKERS D M CRETOIU M S K1ELAK A M | 2012 | Appl Mierobiol Bioteehnoi2012，93，3： | 1 |
| 15 | Complex e- ffects of imatinib on spontaneous and oxytocin-induced con- tractions in human non-pregnant myometrium显示文摘 | Cretoiu S M Simioneseu A A Caravia L | 2011 | Acta Phys- iol Hung2011，98，3： | 1 |
| 16 | Novel type of interstitial cell (Cajal-like) in human fallopian tube显示文摘 | Popescu LM Ciontea SM Cretoiu D | 2005 | J Cell Mol Med2005，9，： | 1 |
| 17 | Telocytes:ultrastructural,immunohistochemical and electrophysiological characteristics in human myometrium显示文摘 | Cretoiu SM Cretoiu D Marin A | 2013 | Reproduction2013，145，： | 1 |
| 18 | Interstitial Cajal-like cells (ICLC) as steroid hormone sensors in human myometrium: immunocytochemical approach 显示文摘 | Cretoiu D Ciontea SM Popescu LM | 2006 | J Cell Mol Med2006，10，3： | 1 |
| 19 | Molecular characterization of invasive and non-invasive Streptococcus pyogenes isolates from Romania 显示文摘 | Luca-Harari B Straut M Cretoiu S | 2008 | J Med Microbiol2008，57，11： | 1 |
| 20 | Interstitial Cajal-like cells of human fallopian tube express estrogen and progesterone receptors 显示文摘 | Cretoiu SM Cretoiu D Suciu L | 2009 | J Mol Histol2009，40，56： | 1 |
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