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| 1 | Aminoguanidine impedes human pancreatic tumor growth and metastasis development in nude mice显示文摘AIM:To study the action of aminoguanidine on pancreatic cancer xenografts in relation to cell proliferation,apoptosis,redox status and vascularization.METHODS:Xenografts of PANC-1 cells were developed in nude mice. The animals were separated into two groups:control and aminoguanidine treated. Tumor growth,survival and appearance of metastases were determined in vivo in both groups. Tumors were excised and ex vivo histochemical studies were performed. Cell growth was assessed by Ki-67 expression. Apoptosis was studied by intratumoral expression of B cell lymphoma-2 protein (Bcl-2) family proteins and Terminal deoxynucleotidyl transferase biotin-dUTP Nick End Labeling (Tunel). Redox status was evaluated by the expression of endothelial nitric oxide synthase (eNOS),catalase,copper-zinc superoxide dismutase (CuZnSOD),manganese superoxide dismutase (MnSOD) and glutathione peroxidase (GPx). Finally,vascularization was determined by Massons trichromic staining,and by VEGF and CD34 expression.RESULTS:Tumor volumes after 32 d of treatment by aminoguanidine (AG) were significantly lower than in control mice (P < 0.01). Median survival of AG mice was significantly greater than control animals (P < 0.01). The appearance of both homolateral and contralateral palpable metastases was significantly delayed in AG group. Apoptotic cells,intratumoral vascularization (trichromic stain) and the expression of Ki-67,Bax,eNOS,CD34,VEGF,catalase,CuZnSOD and MnSOD were diminished in AG treated mice (P < 0.01),while the expression of Bcl-2 and GPx did not change.CONCLUSION:The antitumoral action of aminoguanidine is associated with decreased cell proliferation,reduced angiogenesis,and reduced expression of antioxidant enzymes. | Nora A Mohamad Graciela P Cricco Lorena A Sambuco Máximo Croci Vanina A Medina Alicia S Gutiérrez Rosa M Bergoc Elena S Rivera Gabriela A Martín | 2009 | World Journal of Gastroenterology2009，15，9： | 3 |
| 2 | Hemangioendothelioma of the testis : second reported case显示文摘 | Cricco CF Jr Buck AS | 1980 | J Urol1980，123，1： | 1 |
| 3 | Hybrid Aortic Arch Debranching With Staged Endovascular Completion in DeBakey Type I Aortic Dissection显示文摘 | Antonino G.M. Marullo Samuele Bichi Rocco A. Pennetta Gerardo Di Matteo Antonio M. Cricco Luigi Specchia Fausto Castriota Giampiero Esposito | 2010 | The Annals of Thoracic Surgery2010，，6： | 1 |
| 4 | Histamine regulates pancreatic carcinoma cell growth through H3 and H4 receptors显示文摘 | Cricco G Mohamad NA Sambuco LA | | 0，，1： | 1 |
| 5 | Hybrid One-Stage Approach to Extensive Atherosclerotic Aneurysm of Thoracoabdominal Aorta显示文摘 | Samuele Bichi Antonio M. Cricco Antonino G.M. Marullo Renato Gregorini Giampiero Esposito | 2011 | The Annals of Thoracic Surgery2011，，5： | 1 |
| 6 | The impact of insomnia oncognitive functioning in older adults显示文摘 | Cricco M Simonsick EM Foley DJ | 2001 | J Am Geriatr Soc2001，49，9： | 1 |
| 7 | The impact of insomnia on cognitive functioning in older adults显示文摘 | Simonsick EM Foley DJ | 2001 | J Am Geriatr Soc2001，49，9： | 1 |
| 8 | The impact of insomnia on cognitive functioning in older adults显示文摘 | Cricco M Simonsick EM Foley DJ | 2001 | American Geriatrics Society2001，49，9： | 1 |
| 9 | The impact of insomnia on cognitive functioning in older adults显示文摘 | Cricco M Simonsick EM Foley DJ | 2001 | J Am Geriatr Soe2001，49，9： | 1 |
| 10 | Hybrid one-stage approach to extensive atherosclerotic aneurysm of thoracoabdominal aorta显示文摘 | Bichi S Cricco AM Marullo AM | 2011 | Ann Thorac Surg2011，91，5： | 1 |
| 11 | The Impact of Insomnia on Cognitive Functioning in Older Adults显示文摘 | Cricco M Simonsick E M Foley D J | 2001 | American Geriatrics Society2001，49，9： | 1 |
| 12 | The impact of insomnia on cognitive functioning in older adults显示文摘 | I Cricco M Simonsick E M Foley D J | 2001 | Journal of Amrican Geri- atrics Society2001，49，9： | 1 |
| 13 | Chylothorax: a complication after internal thoracic artery harvesting显示文摘 | Prifit E Cricco A M | 2001 | Ital Heart J2001，2，7： | 1 |
| 14 | The impact of insomnia on cognitive functioning in older adults显示文摘 | Cricco M Simonsick EM Foley DJ | 2001 | J Am Geriatr Soc2001，49，9： | 1 |
| 15 | The impact of insomnia on cognictive functioning in older adults显示文摘 | Cricco M Simonsick EM Foley DJ | 2001 | J Am Geriatr Soc2001，49，9： | 1 |
| 16 | The impact of insomnia on cognitive functioning in older adults 显示文摘 | Cricco M Simonsick EM Foley DJ | 2001 | Am Geriatrics Soc2001，49，9： | 1 |
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