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| 1 | Osteocyte dysfunction promotes osteoarthritis through MMP13-dependent suppression of subchondral bone homeostasis显示文摘Osteoarthritis(OA),long considered a primary disorder of articular cartilage,is commonly associated with subchondral bone sclerosis.However,the cellular mechanisms responsible for changes to subchondral bone in OA,and the extent to which these changes are drivers of or a secondary reaction to cartilage degeneration,remain unclear.In knee joints from human patients with end-stage OA,we found evidence of profound defects in osteocyte function.Suppression of osteocyte perilacunar/canalicular remodeling(PLR)was most severe in the medial compartment of OA subchondral bone,with lower protease expression,diminished canalicular networks,and disorganized and hypermineralized extracellular matrix.As a step toward evaluating the causality of PLR suppression in OA,we ablated the PLR enzyme MMP13 in osteocytes while leaving chondrocytic MMP13 intact,using Cre recombinase driven by the 9.6-kb DMP1 promoter.Not only did osteocytic MMP13 deficiency suppress PLR in cortical and subchondral bone,but it also compromised cartilage.Even in the absence of injury,osteocytic MMP13 deficiency was sufficient to reduce cartilage proteoglycan content,change chondrocyte production of collagen II,aggrecan,and MMP13,and increase the incidence of cartilage lesions,consistent with early OA.Thus,in humans and mice,defects in PLR coincide with cartilage defects.Osteocyte-derived MMP13 emerges as a critical regulator of cartilage homeostasis,likely via its effects on PLR.Together,these findings implicate osteocytes in bone-cartilage crosstalk in the joint and suggest a causal role for suppressed perilacunar/canalicular remodeling in osteoarthritis. | Courtney MMazur Jonathon JWoo Cristal SYee Aaron JFields Claire Acevedo Karsyn NBailey Serra Kaya Tristan WFowler Jeffrey CLotz Alexis Dang Alfred CKuo Thomas PVail Tamara Alliston | 2019 | Bone Research2019，7，4： | 10 |
| 2 | Screen-printed amper- ometric microcell for proline iminopeptidase enzyme activity assay 显示文摘 | Nagy G Gyurcsanyi RE Cristalli CA | 2000 | Biosens Bioelectron2000，15，56： | 1 |
| 3 | Hairpin-Line and Hybrid Hairpinline/Half-Wave Parallel-Coupled-Line Filters显示文摘 | Cristal E G Frankel S | 1972 | IEEE Trans Microwave Theory Tech1972，20，： | 1 |
| 4 | Effects ofmicrowaves(900 MHz)on the cochlear receptor:exposuresystems and preliminary results显示文摘 | Marino C Cristalli G Galloni P | 2000 | Radiat Environ Biophys2000，39，2： | 1 |
| 5 | Adenosine deaminase: functional implications and different classes of inhibitors 显示文摘 | Cristalli G Costanzi S Lambertucci C | 2001 | Med Res Rev2001，21，： | 1 |
| 6 | Acoustic emissions for particle size of powers through signal processing techni ques显示文摘 | Bastari A Cristalli C Morlacchi R | 2011 | Mechanical Systems and Signal Processing2011，25，3： | 1 |
| 7 | 显示文摘 | Faglia G Comoni E Cristalli A | 1999 | Sensors and Actuators1999，55，： | 1 |
| 8 | Formation of polycyclic aromatic hydrocarbons by ionizing radiations显示文摘 | Perez G Lilla E Cristalli A | 1986 | Chemosphere1986，15，： | 1 |
| 9 | Hairpin-line and hybrid hairpin-line/half-wave parallel-coupled-line filters显示文摘 | CRISTAL E G FRANKEL S | 1972 | IEEE Trans Microwave Theory Teeh1972，20，11： | 1 |
| 10 | Occurrence and risk assessment of organophosphorus and brominated flame retardants in the River Aire (UK)显示文摘 | Cristale J Katsoyiannis A Sweetman A J | 2013 | Environmental Pollution2013，179，： | 1 |
| 11 | Tapped-line coupled transmission lines with applications to interdigital and combline filters显示文摘 | E G Cristal | 1975 | IEEE Trans Microwave Theory Tech1975，23，： | 1 |
| 12 | A mathematical study of some biomechanical factors affecting the oscillometric blood pressure measurement 显示文摘 | Mauro ursino Cristina Cristalli | 1996 | IEEE Trans Biomed Eng1996，43，： | 1 |
| 13 | Use of vancomycin chiral stationary phase for the enantiomeric resolution of basic and acidic compounds by nano-liquid chromatography显示文摘 | ORAZIO D ATURKI Z CRISTALLI M | 2005 | J Chromatogr:A2005，1081，1： | 1 |
| 14 | Screen-Printed amperometrie mieroeell for praline iminopeptidase enzyme activity assay显示文摘 | Nagy G Gyurcsanyi RE Cristalli CA Neuman MR Lindner E | 2000 | Bifaosens Bioeleetron 2000 Aug2000，15，56： | 1 |
| 15 | Some Considerations of Tourism Location in Europe :The Peripheral Region Underdeveloped Countries Recreation Areas 显示文摘 | Cristaller W | 1964 | Paper and Proceedings of Regional Science Association1964，12，1： | 1 |
| 16 | Screen-printed amperometric microcell for proline iminopeptidase enzyme activity assay显示文摘 | Nagy G Gyurcsanyi RE Cristalli CA | 2000 | Biosens Bioelectron2000，15，56： | 1 |
| 17 | Light EnchandedGas Sensor Properties of Indium Oxide and Tin Dioxide Sensors显示文摘 | Comini E Cristalli A Faglia G | 2000 | Sensors and Actuator B2000，65，： | 1 |
| 18 | Multiplexer channel-separation units usinginterdigital and parallel-coupled filters显示文摘 | G L Matthaei E G Cristal | 1965 | IEEE Trans-MTT1965，13，5： | 1 |
| 19 | Use ofvancomycin chiral stationary phase for the enantiomeric resolution of basic and acidic compounds by nano-liquid chromatography显示文摘 | D'Orazio G Aturki Z Cristalli M | | 0，，01： | 1 |
| 20 | Some Considerations of Tourism Location in Europe:The Peripheral Region Underdeveloped Countries Recreation Areas 显示文摘 | Cristaller W | 1964 | Paper and Proceedings of Regional Science Association1964，12，1： | 1 |
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