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| 1 | Nonalcoholic fatty liver disease, metabolic risk factors, and hepatocellular carcinoma: An open question显示文摘Non-alcoholic liver disease(NAFLD) defines liver abnormalities ranging from simple steatosis to nonalcoholic steatohepatitis with or without cirrhosis development, occurring in the absence of significant alcohol consumption, use of teratogenic medication, or hereditary disorders.The association between NAFLD and metabolic syndrome is well documented and widely recognized.Obesity, type 2 diabetes mellitus(T2DM), and dyslipidemia are the most common metabolic risk factors associated with NAFLD.Among the components of metabolic syndrome, current evidence strongly indicates obesity and diabetes as hepatocellular carcinoma(HCC) risk factors.There is also growing evidence that suggests an increased risk of HCC in NAFLD patients, even surpassing other etiologies in some high-income countries.Epidemiologic data demonstrate a parallel rise in prevalence of obesity, diabetes, NAFLD, and HCC.As obesity and its related diseases have steadily afflicted larger populations, HCC incidence is expected to increase in the future.Pathophysiologic mechanisms that underlie NAFLD development and subsequent progression to nonalcoholic steatohepatitis and cirrhosis(insulin resistance and hyperinsulinemia, oxidative stress, hepatic stellate cell activation, cytokine/adipocytokine signaling pathways, and genetic and environmental factors) appear to play a significant role in the development of NAFLD-related HCC.However, a comprehensive view of molecular mechanisms linking obesity, T2 DM, and NAFLD-related HCC, as well as the exact sequence of molecular events, is still not understood in its entirety.Good-quality data are still necessary, and efforts should continue towards better understanding the underlying carcinogenic mechanisms of NAFLD-related HCC.In this paper, we aimed to centralize the most important links supporting these relationships, focusing on obesity, T2 DM, and NAFLD-related HCC, as well as point out the major gaps in knowledge regarding the underlying molecular mechanisms behind them. | Letitia Adela Maria Streba Cristin Constantin Vere Ion Rogoveanu Costin Teodor Streba | 2015 | World Journal of Gastroenterology2015，21，14： | 15 |
| 2 | Contrast-enhanced ultrasonography parameters in neural network diagnosis of liver tumors显示文摘AIM:To study the role of time-intensity curve(TIC) analysis parameters in a complex system of neural networks designed to classify liver tumors.METHODS:We prospectively included 112 patients with hepatocellular carcinoma(HCC)(n = 41),hypervascular(n = 20) and hypovascular(n = 12) liver metastases,hepatic hemangiomas(n = 16) or focal fatty changes(n = 23) who underwent contrast-enhanced ultrasonography in the Research Center of Gastroenterology and Hepatology,Craiova,Romania.We recorded full length movies of all contrast uptake phases and post-processed them offline by selecting two areas of interest(one for the tumor and one for the healthy surrounding parenchyma) and consecutive TIC analysis.The difference in maximum intensities,the time to reaching them and the aspect of the late/portal phase,as quantified by the neural network and a ratio between median intensities of the central and peripheral areas were analyzed by a feed forward back propagation multi-layer neural network which was trained to classify data into five distinct classes,corresponding to each type of liver lesion.RESULTS:The neural network had 94.45% training accuracy(95% CI:89.31%-97.21%) and 87.12% testing accuracy(95% CI:86.83%-93.17%).The automatic classification process registered 93.2% sensitivity,89.7% specificity,94.42% positive predictive value and 87.57% negative predictive value.The artificial neural networks(ANN) incorrectly classified as hemangyomas three HCC cases and two hypervascular metastases,while in turn misclassifying four liver hemangyomas as HCC(one case) and hypervascular metastases(three cases).Comparatively,human interpretation of TICs showed 94.1% sensitivity,90.7% specificity,95.11% positive predictive value and 88.89% negative predictive value.The accuracy and specificity of the ANN diagnosis system was similar to that of human interpretation of the TICs(P = 0.225 and P = 0.451,respectively).Hepatocellular carcinoma cases showed contrast uptake during the arterial phase followed by wash-out in the portal and first seconds of the late phases.For the hypovascular metastases did not show significant contrast uptake during the arterial phase,which resulted in negative differences between the maximum intensities.We registered wash-out in the late phase for most of the hypervascular metastases.Liver hemangiomas had contrast uptake in the arterial phase without agent wash-out in the portallate phases.The focal fatty changes did not show any differences from surrounding liver parenchyma,resulting in similar TIC patterns and extracted parameters.CONCLUSION:Neural network analysis of contrastenhanced ultrasonography-obtained TICs seems a promising field of development for future techniques,providing fast and reliable diagnostic aid for the clinician. | Costin Teodor Streba Mihaela Ionescu Dan Ionut Gheonea Larisa Sandulescu Tudorel Ciurea Adrian Saftoiu Cristin Constantin Vere Ion Rogoveanu | 2012 | World Journal of Gastroenterology2012，18，32： | 11 |
| 3 | Psychosocial stress and liver disease status显示文摘'Psychosocial stress' is an increasingly common concept in the challenging and highly-demanding modern society of today. Organic response to stress implicates two major components of the stress system, namely the hypothalamic-pituitary-adrenal axis and the sympathetic nervous system. Stress is anamnestically reported by patients during the course of disease, usually accompanied by a decline in their overall health status. As the mechanisms involving glucocorticoids and catecholamines have been deciphered, and their actions on immune cell function deeper understood, it has become clear that stress has an impact on hepatic inflam-matory response. An increasing number of articles have approached the link between psychosocial stress and the negative evolution of hepatic diseases. This article reviews a number of studies on both human populations and animal models performed in recent years, all linking stress, mainly of psychosocial nature, and the evolution of three important liver-related pathological entities: viral hepatitis, cirrhosis and hepatocellular carcinoma. | Cristin Constantin Vere Costin Teodor Streba Letitia Maria Streba Alin Gabriel Ionescu Felix Sima | 2009 | World Journal of Gastroenterology2009，15，24： | 7 |
| 4 | Malaria: Global progress 2000-2015 and future challenges显示文摘Background:2015 was the target year for malaria goals set by the World Health Assembly and other international institutions to reduce malaria incidence and mortality.A review of progress indicates that malaria programme financing and coverage have been transformed since the beginning of the millennium,and have contributed to substantial reductions in the burden of disease.Findings:Investments in malaria programmes increased by more than 2.5 times between 2005 and 2014 from US$960 million to US$2.5 billion,allowing an expansion in malaria prevention,diagnostic testing and treatment programmes.In 2015 more than half of the population of sub-Saharan Africa slept under insecticide-treated mosquito nets,compared to just 2%in 2000.Increased availability of rapid diagnostic tests and antimalarial medicines has allowed many more people to access timely and appropriate treatment.Malaria incidence rates have decreased by 37%globally and mortality rates by 60%since 2000.It is estimated that 70%of the reductions in numbers of cases in sub-Saharan Africa can be attributed to malaria interventions.Conclusions:Reductions in malaria incidence and mortality rates have been made in every WHO region and almost every country.However,decreases in malaria case incidence and mortality rates were slowest in countries that had the largest numbers of malaria cases and deaths in 2000;reductions in incidence need to be greatly accelerated in these countries to achieve future malaria targets.Progress is made challenging because malaria is concentrated in countries and areas with the least resourced health systems and the least ability to pay for system improvements.Malaria interventions are nevertheless highly cost-effective and have not only led to significant reductions in the incidence of the disease but are estimated to have saved about US$900 million in malaria case management costs to public providers in sub-Saharan Africa between 2000 and 2014.Investments in malaria programmes can not only reduce malaria morbidity and mortality,thereby contributing to the health targets of the Sustainable Development Goals,but they can also transform the well-being and livelihood of some of the poorest communities across the globe. | Richard E.Cibulskis Pedro Alonso John Aponte Maru Aregawi Amy Barrette Laurent Bergeron Cristin A.Fergus Tessa Knox Michael Lynch Edith Patouillard Silvia Schwarte Saira Stewart Ryan Williams | 2016 | Infectious Diseases of Poverty2016，5，1： | 4 |
| 5 | 老年人处方遗漏筛查工具第2版(中文版)显示文摘近年来我国老年人口数量迅速增加,2013年老年人口突破2亿大关。老年人常伴有多种疾病且同时服用多种药物,容易出现药物相互作用和药物不良反应,所以老年人用药问题是医务人员关注的重点。老年人不适当用药问题主要包括两个方面:老年人需要避免使用的药物和老年人需要使用而未使用的药物。 | Denis O'Mahony David O'Sullivan Stephen Byrne Marie Noelle O'Connor Cristin Ryan Paul Gallagher 侯凯旋 邢晓璇 闫素英 | 2017 | 药物不良反应杂志2017，19，5： | 4 |
| 6 | Suppression of bile acid synthesis by thyroid hormone in primary human hepatocytes显示文摘瞄准:甲状腺激素在人改变胆汁酸新陈代谢,这被知道,然而,单个酶上的效果是困难的阐明。这主要由于生产胆汁酸的人的肝房间线的缺乏。我们使用了主要人的 hepatocytes 的文化在胆汁酸合成上学习三碘甲状腺氨酸(T (3 )) 的效果。方法:主要 hepatocytes 从从由于内在的恶意经历肝切除术的三个不同病人获得的肝织物被孤立。hepatocytes 在没有浆液的条件下面是有教养的并且从 d 对待 1 到 d 5 与包含 0.1 的文化 - T (3 ) 的 1000 nmol/L。关键酶的胆汁酸形成和 mRNA 层次被分析。结果:T (3 ) 的最低集中减少了胆酸(CA ) 形成到到 d 上的控制的 52%-75% 的控制和 chenodeoxycholic 酸(CDCA ) 的 43%-53% 5。最高的剂量当 CDCA 形成在控制的 50%-117% 留下了时,推进减少的 CA 形成到控制的 16%-48% 。胆固醇 7alpha-hydroxylase (CYP7A1 ) 和甾醇 12alpha-hydroxylase (CYP8B1 ) 的 mRNA 层次的表示 dose-dependently 减少了。甾醇 27-hydroxylase (CYP27A1 ) 层次也减少了,然而并非到一样的程度。结论:T (3 ) dose-dependently 减少了与 CYP7A1 和 CYP8B1 的减少的表示同时的全部的胆汁酸形成。CA 形成比 CDCA 被禁止到更高的度,导致在 CA /CDCA 比率的显著减少。 | Ewa Cristine Siljevik Ellis | 2006 | World Journal of Gastroenterology2006，12，29： | 3 |
| 7 | Consistency features and fuzzy-based segmentation for shadow and reflection detection in digital image forgery显示文摘Advances in photo editing software have made it possible to generate visually convincing photographic forgeries which have been increased tremendously in recent years. In order to alleviate the problem of image forgery, a handful of techniques have been presented in the literature to detect forgery either in shadow or reflection. This paper aims to develop a technique to detect the image forgery either in shadow or reflection using features enabled neural network. The proposed technique of image forgery detection contains three important steps, like segmentation, feature extraction and detection. In segmentation, shadow points and reflection points are identified using map-based segmentation and FCM clustering. Then, feature points from the shadow points and reflective parts are extracted by considering texture consistency and strength consistency using LVP operator. The final step of forgery detection is performed using the feed forward neural network, where a new algorithm called ABCLM is developed for training of neural network weights. The performance is analyzed with four existing algorithms using measures such as accuracy and MSE. From the analysis, we understand that the proposed technique obtained the maximum accuracy of 80.49%. | Rajan CRISTIN Velankanni CYRIL RAJ | 2017 | Science China(Information Sciences)2017，60，8： | 2 |
| 8 | Microbiological air quality in tie-stall dairy barns and some factors that influence it显示文摘 | SILVANA P CRISTIN B EVA ANDREA D | 2011 | Af J Agric Res2011，6，32： | 1 |
| 9 | Release of dissolved amino acids by flagellates and ciliates grazing on bacteria显示文摘 | Cristine F P Markus K Fereieoum R | 1998 | Oceanologica Acta1998，21，3： | 1 |
| 10 | Poly(2-ethyl-2-ox- azoline)-PLA-PEI amphiphilie triblock mieells for co-deliv- ery of minicircle DNA and chemotherapeutics显示文摘 | Vitor M Cristine G Duarte D | 2014 | J Con- trolled Release2014，189，： | 1 |
| 11 | Fractionation studies of trace elements in contaminated soils and sediments: a review of sequential extraction procedures显示文摘 | Cristine Gleyzes Sylvaine TeUier Michel Astruc | 2002 | Trends in Analytical Chemistry2002，21，67： | 1 |
| 12 | Genes regulated by arachidonic and oleic acids in Raji cells显示文摘 | ROZANGELA VERLENGIA RENATA GORJAO CARLA CRISTINE KANUNFRE | 2003 | Lipids12003，38，： | 1 |
| 13 | On-line preconcentration and speciation of arsenic by flow injection hydride generation atomic absorption spectrophotometry显示文摘 | CRISTINE INGRID S LILIBETH DLC N COO FLORIAN R | 2005 | Talanta2005，68，： | 1 |
| 14 | YB-1:oncoprotein,prognosticmarker and therapeutic target?显示文摘 | Annette L Cristin G Adele GW | 2013 | Biochem J2013，449，1： | 1 |
| 15 | Variability in protein quality used for embryo culture: embryotoxicity of the stabilizer octanoic acid显示文摘 | Phoebe H. Leonard M. Cristine Charlesworth Linda Benson David L. Walker Jolene R. Fredrickson Dean E. Morbeck | 2013 | Fertility and Sterility2013，，2： | 1 |
| 16 | Vascular development in embryoid bodies: quantification of transgenic intervention and antiangiogenic treatment显示文摘 | Amanda Lisabeth Evans James Bryant Jeremy Skepper Stephen K. Smith Cristin G. Print D. Stephen Charnock-Jones | 2007 | Angiogenesis2007，，3： | 1 |
| 17 | In situ characterizaiton of soil clay content with visible near-infrared diffuse reflectance spectroscopy显示文摘 | Travis H Waiser Cristine L S Morgan David J Brown | 2007 | Soil Science Society of America2007，71，2： | 1 |
| 18 | Model-free control of nonlinear stochastic systems with discrete-time measurement 显示文摘 | Spall J C Cristin J A | 1998 | IEEE Transactions on Automatic Control1998，43，： | 1 |
| 19 | Functional role of inflame matory cytokines and anti-inflammatory molecules in seizures and epilep togenesis显示文摘 | Annamaria V Daniela M Cristinal R | 2002 | Epilepsia2002，43，5： | 1 |
| 20 | Accelerated endometrial maturation in the luteal phase of cycles utilizing controlled o- varian hyperstimulation :impact of gonadotropin-releasing hor- mone agonists versus antagonists 显示文摘 | Peynmn S Robert B Cristin C | 2004 | Fertil Steril2004，82，1： | 1 |
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