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| 1 | Expert consensus on standardized diagnosis and treatment for heat stroke(draft)显示文摘Overview Heats stroke(HS)is severe sunstroke caused by a rapid increase in one’s core temperature in excess of 40°C from exposure to a hot and humid environment.HS is accompanied by serious clinical syndromes that damage multiple organ systems.h ese syndromes include burning skin and impaired awareness,such as delir ium,conv ul sions,and loss of consciousness.Exertional heat stroke(EHS)is caused by a rapid increase in one’s core temperature in excess of 40°C from high | People’s Liberation Army Professional Committee of Critical Care Medicine | 2015 | Journal of Medical Colleges of PLA(China)2015，30，1： | 11 |
| 2 | 重症加强治疗病房(ICU)建设与管理指南(2006)显示文摘 | Society of Critical Care Medicine, Chinese Medical Association. No.1, Shuaifuyuan, Dongcheng District, Beijing. 100730, PRC | 2006 | 中国医院2006，10，7： | 9 |
| 3 | Microarray,SAGE and their applications to cardiovascular diseases显示文摘The wealth of DNA data generated by the human genome project coupling with recently invented high-throughput gene expression profiling techniques has dramatically sped up the process for biomedical researchers on elucidating the role of genes in human diseases. One powerful method to reveal insight into gene functions is the systematic analysis of gene expression. Two popular high-throughput gene expression technologies, microarray and Serial Analysis of Gene Expression (SAGE) are capable of producing large amounts of gene expression data with the potential of providing novel insights into fundamental disease processes, especially complex syndromes such as cardiovascular disease, whose etiologies are due to multiple genetic factors and their interplay with the environment. Microarray and SAGE have already been used to examine gene expression patterns of cell-culture, animal and human tissues models of cardiovascular diseases. In this review, we will first give a brief introduction of microarray and SAGE technologies and point out their limitations. We will then discuss the major discoveries and the new biological insightsthat have emerged from their applications to cardiovascular diseases. Finally we will touch upon potential challenges and future developments in this area. | SHUI QING YE, TERA LAVOIE, DAVID C USHER, LI Q. ZHANG1 Division of Pulmonary and Critical Care Medicine, Johns Hopkins University, School of Medicine, Baltimore, MD 21224, USA2Department of Biological Science, University of Delaware, Newark, DE 19716, USA | 2002 | Cell Research2002，12，2： | 5 |
| 4 | Association of fluid balance trajectories with clinical outcomes in patients with septic shock:A prospective multicenter cohort study显示文摘Background:Septic shock has a high incidence and mortality rate in Intensive Care Units(ICUs).Earlier intravenous fluid resuscitation can significantly improve outcomes in septic patients but easily leads to fluid overload(FO),which is associated with poor clinical outcomes.A single point value of fluid cannot provide enough fluid information.The aim of this study was to investigate the impact of fluid balance(FB)latent trajectories on clinical outcomes in septic patients.Methods:Patients were diagnosed with septic shock during the first 48 h,and sequential fluid data for the first 3 days of ICU admission were included.A group-based trajectory model(GBTM)which is designed to identify groups of individuals following similar developmental trajectories was used to identify latent subgroups of individuals following a similar progression of FB.The primary outcomes were hospital mortality,organ dysfunction,major adverse kidney events(MAKE)and severe respiratory adverse events(SRAE).We used multivariable Cox or logistic regression analysis to assess the association between FB trajectories and clinical outcomes.Results:Nine hundred eighty-six patients met the inclusion criteria and were assigned to GBTM analysis,and three latent FB trajectories were detected.64(6.5%),841(85.3%),and 81(8.2%)patients were identified to have decreased,low,and high FB,respectively.Compared with low FB,high FB was associated with increased hospital mortality[hazard ratio(HR)=1.63,95%CI 1.22–2.17],organ dysfunction[odds ratio(OR)=2.18,95%CI 1.22–3.42],MAKE(OR=1.80,95%CI 1.04–2.63)and SRAE(OR=2.33,95%CI 1.46–3.71),and decreasing FB was significantly associated with decreased MAKE(OR=0.46,95%CI 0.29–0.79)after adjustment for potential covariates.Conclusion:Latent subgroups of septic patients followed a similar FB progression.These latent fluid trajectories were associated with clinical outcomes.The decreasing FB trajectory was associated with a decreased risk of hospital mortality and MAKE. | Mei-Ping Wang Li Jiang Bo Zhu Bin Du Wen Li Yan He Xiu-Ming Xi China Critical Care Sepsis Trial(CCCST)workgroup | 2021 | Military Medical Research2021，8，3： | 4 |
| 5 | Definition for sepsis and organ failure and guideline for the use of innovative therapies in sepsis显示文摘 | Menbers of the American College of Chest Physicians/Society of Critical Care Medicine Consensus Conference | 1992 | Crit Care Med1992，20，： | 2 |
| 6 | Pandemic influenza 2009: Impact of vaccination coverage on critical illness in children, a Canada and France observational study显示文摘AIM To study the impact of vaccination critical illness due to H1N1pdm09, we compared the incidence and severity of H1N1pdm09 infection in Canada and France.METHODS We studied two national cohorts that included children with documented H1N1pdm09 infection, admitted to a pediatric intensive care unit(PICU) in Canada and in France between October 1, 2009 and January 31, 2010.RESULTS Vaccination coverage prior to admission to PICUs was higher in Canada than in France(21% vs 2% of children respectively, P < 0.001), and in both countries, vaccination coverage prior to admission of these critically ill patients was substantially lower than in the general pediatric population(P < 0.001). In Canada, 160 children(incidence = 2.6/100000 children) were hospitalized in PICU compared to 125 children(incidence = 1.1/100000) in France(P < 0.001). Mortality rates were similar in Canada and France(4.4% vs 6.5%, P = 0.45, respectively), median invasive mechanical ventilation duration and mean PICU length of stay were shorter in Canada(4 d vs 6 d, P = 0.02 and 5.7 d vs 8.2 d, P = 0.03, respectively). H1N1pdm09 vaccination prior to PICU admission was associated with a decreased risk of requiring invasive mechanical ventilation(OR = 0.30, 95%CI: 0.11-0.83, P = 0.02).CONCLUSION The critical illness due to H1N1pdm09 had a higher incidence in Canada than in France. Critically ill children were less likely to have received vaccination prior to hospitalization in comparison to general population and children vaccinated had lower risk of ventilation. | Olivier Fléchelles Olivier Brissaud Robert Fowler Thierry Ducruet Philippe Jouvet the Pediatric Canadian Critical Care Trials Group H1N1 Collaborative and Groupe Francophone de Réanimation et Urgences Pédiatriques | 2016 | World Journal of Clinical Pediatrics2016，5，4： | 2 |
| 7 | Assessing a novel critical care ultrasonography training program for intensive care unit nurses in China显示文摘Critical care ultrasonography(CCUS)is essential in the evaluation of shock,respiratory failure,and to guide central venous access.[1] Nurses also use ultrasound for nursing practice such as thrombosis screening,ultrasound-guided vascular puncture,feeding tube placement,and lung physical therapy.[2]CCUS strengths are lack of radiation,portability,and low costs.Therefore,CCUS has considerable clinical use in critical care. | Jianhua Sun Yue Wang Qing Zhang Xin Li Wei He Yangong Chao Xiaoting Wang Dawei Liu Critical Care Ultrasound Study Grop(CCUSG) | 2022 | Chinese Medical Journal2022，，8： | 2 |
| 8 | Guidelines for developing admission and discharge policies for pediatric intensive care unit 显示文摘 | American College of Critical Care Medicine of the Society of Critical Care Medicine and American Academy of Pediatrics | 1999 | Crit Care Med1999，27，4： | 1 |
| 9 | Definitions for sepsis and organ failure and guidelines for the use of innovative therapies in sepsis显示文摘 | AMERICAN COLLEGE OF CHEST PHYSICIAN/SOCIETY OF CRITICAL CARE MEDICINE CONSENSUS | 1992 | Crit Care Med1992，20，： | 1 |
| 10 | Definitions for sepsis and organ failure and guidelines for the use of innovative therapies in sepsis显示文摘 | American College of Chest Physicians/Society of Critical Care Medicine Consensus Conference | 1992 | Crit Care Med1992，20，6： | 1 |
| 11 | Definitions for sepsis and organ faiture and guidelines in sepsis 显示文摘 | American College of Chest Physicians/Society of Critical Care Medi- cine Consensics Conference Committee ACCP/SCCM Consensus Committee | 1992 | Crit Care Med1992，20，： | 1 |
| 12 | American College of Chest Physicians/Society of Critical Care Medicine Consensus Conference:Definitions for sepsis and organ failure and guidelines for the use of innovative therapies in sepsis显示文摘 | Members of the American College of Chest Physicians/Society of Critical Care Medicine Consensus Conference Committee | 1992 | Crit Care Med1992，20，： | 1 |
| 13 | Guidelines for the management of severe traumatic brain injury 显示文摘 | Brain Trauma Foundation American Association of Neurological Surgeons Congress of Neurological Surgeons Joint Section on Neurotrauma and Critical Care | 2007 | J Neurotrauma2007，24，1： | 1 |
| 14 | Evidence - based guidelines for weaning and discontinuing ventilator support 显示文摘 | A Collective Task Force Facilitated By the American College Of Chest Physicians the American Association for Respiratory Care and the American College of Critical Care Medicine | 2001 | Chest2001，120，6： | 1 |
| 15 | Definitions for sepsis and organ failure and guidelines for the use of innovative therapies in sepsis显示文摘 | American College of Chest Physiciano Society of Critical Care Medicine Consensus Conference | 1992 | Crit Care Med1992，20，6： | 1 |
| 16 | Definitions for sepsis and organ failure and guide- lines for the use of innovative therapies in sepsis 显示文摘 | American College of Chest Physicians/Society of Critical Care Medicine Consensus Conference | 1992 | Crit Care Med1992，20，6： | 1 |
| 17 | Acute lung injury and the acute respiratory distress syndrome in Ireland:a prospective audit of epidemiology and management显示文摘 | IRISH critical care trials group | 2008 | Crit Care2008，12，： | 1 |
| 18 | Definitions for sepsis and multiple organ failure and guidelines for the use of innovative therapies in sepsis显示文摘 | American College of Chest Physicians/Society of Critical Care Medicine Consensus Conference | 1992 | Crit Care Med1992，20，6： | 1 |
| 19 | definition for sepsis and organ failure and guidelines for the use of innovative thempies in sepsis显示文摘 | American collgeg ofchest physicians socicty of critical care medicine consensus conference | 1992 | Crit Care Med1992，20，： | 1 |
| 20 | Definitions for sepsis and organ failure and guidelines for the use of innovative therapies in sepsis显示文摘 | American College of Chest Physicians of Critical Care Medicine Consensus Conference | 1992 | Crit Care Med1992，20，： | 1 |
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