|
|
|
题名
|
作者
|
年代
|
出处
|
被引量
|
| 1 | Heavy Metal Contamination of Agricultural Soils in Taiyuan, China显示文摘To evaluate the current state of the environmental quality of agricultural soils in Taiyuan City, a hotspot for China's industrial development, the concentrations of 8 heavy metals in soils were investigated by means of extensive sampling in farmlands, forestlands,and grasslands in the city. Statistical analyses and spatial distribution maps were used to identify the most significant heavy metal pollutants. The mean concentrations of As, Cd, Cu, Hg, Pb, Zn, Ni, and Cr were slightly higher than their background values in Taiyuan's topsoil, but were lower than the maximum permissible concentrations in the Chinese Environmental Quality Standard for agricultural soils. Farmland soils in Taiyuan had the highest average Cd, Cu, Hg, Pb, Zn, and Cr concentrations, but the As and Ni concentrations did not differ significantly among the farmland, forestland, and grasslands. Soil contamination by Cd, Cu, Hg, Pb,Zn, and Cr was mainly derived from farming practices, especially the use of sewage water for irrigation. In contrast, As and Ni might derive mainly from the soil parent material. The identification of heavy metal sources in agricultural soils may provide a basis for taking appropriate action to protect soil quality. | LIU Yong WANG Huifeng LI Xiaoting LI Jinchang | 2015 | Pedosphere2015，25，6： | 20 |
| 2 | Enhanced rectification, transport property and photocurrent generation of multilayer ReSe2/MoS2 p-n heterojunctions显示文摘 | Xiaoting Wang Le Huang Yuting Peng Nengjie Huo Kedi Wu Congxin Xia Zhongming Wei Sefaattin Tongay Jingbo Li | 2016 | Nano Research2016，9，2： | 16 |
| 3 | Diffusion-tensor imaging as an adjunct to dynamic contrastenhanced MRI for improved accuracy of differential diagnosis between breast ductal carcinoma in situ and invasive breast carcinoma显示文摘Objective:To determine the value of diffusion-tensor imaging(DTI) as an adjunct to dynamic contrastenhanced magnetic resonance imaging(DCE-MRI) for improved accuracy of differential diagnosis between breast ductal carcinoma in situ(DCIS) and invasive breast carcinoma(IBC).Methods:The MRI data of 63 patients pathologically confirmed as breast cancer were analyzed.The conventional MRI analysis metrics included enhancement style,initial enhancement characteristic,maximum slope of increase,time to peak,time signal intensity curve(TIC) pattern,and signal intensity on FST2 WI.The values of apparent diffusion coefficient(ADC),directionally-averaged mean diffusivity(D_(avg)),exponential attenuation(EA),fractional anisotropy(FA),volume ratio(VR) and relative anisotropy(RA)were calculated and compared between DCIS and IBC.Multivariate logistic regression was used to identify independent factors for distinguishing IBC and DCIS.The diagnostic performance of the diagnosis equation was evaluated using the receiver operating characteristic(ROC) curve.The diagnostic efficacies of DCEMRI,DWI and DTI were compared independendy or combined.Results:EA value,lesion enhancement style and TIC pattern were identified as independent factor for differential diagnosis of IBC and DCIS.The combination diagnosis showed higher diagnostic efficacy than a single use of DCE-MRI(P=0.02),and the area of the curve was improved from 0.84(95%CI,0.67-0.99) to0.94(95%CI,0.85-1.00).Conclusions:Quantitative DTI measurement as an adjunct to DCE-MRI could improve the diagnostic performance of differential diagnosis between DCIS and IBC compared to a single use of DCE-MRI. | Yuan Wang Xiaopeng Zhang Kun Cao Yanling Li Xiaoting Li Liping Qi Lei Tang Zhilong Wang Shunyu Gao | 2015 | Chinese Journal of Cancer Research2015，27，2： | 12 |
| 4 | Prognostic factors for transarterial chemoembolization combined with sustained oxaliplatin-based hepatic arterial infusion chemotherapy of colorectal cancer liver metastasis显示文摘Objective: To investigate the prognostic factors in chemorefractory colorectal cancer liver metastasis(CRCLM)patients treated by transarterial chemoembolization(TACE) and sustained hepatic arterial infusion chemotherapy(HAIC).Methods: Between 2006 and 2015, 162 patients who underwent 763 TACE and HAIC in total were enrolled in this retrospective study, including 110 males and 52 females, with a median age of 60(range, 26–83) years.Prognostic factors were assessed with Log-rank test, Cox univariate and multivariate analyses.Results: The median survival time(MST) and median progression-free survival(PFS) of the 162 patients from first TACE/HAIC were 15.6 months and 5.5 months respectively. Normal serum carbohydrate antigen 19-9(CA19-9, <37 U/m L)(P<0.001) and carbohydrate antigen 72-4(CA72-4, <6.7 U/m L)(P=0.026), combination with other local treatment(liver radiotherapy or liver radiofrequency ablation)(P=0.034) and response to TACE/HAIC(P<0.001) were significant factors related to survival after TACE/HAIC in univariate analysis. A multivariate analysis revealed that normal serum CA19-9(P<0.001), response to TACE/HAIC(P<0.001) and combination with other local treatment(P=0.001) were independent factors among them.Conclusions: Our findings indicate that serum CA19-9 <37 U/m L and response to TACE/HAIC are significant prognostic indicators for this combined treatment, and treated with other local treatment could reach a considerable survival benefit for CRCLM. This could be useful for making decisions regarding the treatment of CRCLM. | Hangyu Zhang Jianhai Guo Song Gao Pengjun Zhang Hui Chen Xiaodong Wang Xiaoting Li Xu Zhu | 2017 | Chinese Journal of Cancer Research2017，29，1： | 12 |
| 5 | Methane emissions from rice fields under continuous straw return in the middle-lower reaches of the Yangtze River显示文摘A three-year experiment was conducted in the middle-lower reaches of the Yangtze River in China to study the influence of continuous wheat straw return during the rice season and continuous rice straw return in wheat on methane (CH 4 ) emissions from rice fields in which, the rice-wheat rotation system is the most dominant planting pattern. The field experiment was initiated in October 2009 and has continued since the wheat-growing season of that year. The analyses for the present study were conducted in the second (2011) and third (2012) rice growing seasons. Four treatments, namely, the continuous return of wheat straw and rice straw in every season (WR), of rice straw but no wheat straw return (R), of wheat straw but no rice straw return (W) and a control with no straw return (CK), were laid out in a randomized split-plot design. The total seasonal CH 4 emissions ranged from 107.4 to 491.7 kg/ha (2011) and 160.3 to 909.6 kg/ha (2012). The increase in CH 4 emissions for treatments WR and W were 289% and 230% in the second year and 185% and 225% in the third year, respectively, in relation to CK. We observed less methane emissions in the treatment R than in CK by 14%-43%, but not statistically significant. Treatment R could increase rice productivity while no more CH 4 emission occurs. The difference in the total CH 4 emissions mainly related to a difference in the methane flux rate during the first 30-35 days after transplant in the rice growing season, which was caused by the amount of dissolved oxygen in paddy water and the amount of reducible soil materials. | Pengfu Hou Ganghua Li Shaohua Wang Xin Jin Yiming Yang Xiaoting Chen Chengqiang Ding Zhenghui Liu Yanfeng Ding | 2013 | Journal of Environmental Sciences2013，25，9： | 10 |
| 6 | Essential roles of exosome and circRNA_101093 on ferroptosis desensitization in lung adenocarcinoma显示文摘Background:Resistance to ferroptosis,a regulated cell death caused by irondependent excessive accumulation of lipid peroxides,has recently been linked to lung adenocarcinoma(LUAD).Intracellular antioxidant systems are required for protection against ferroptosis.The purpose of the present studywas to investigate whether and how extracellular system desensitizes LUAD cells to ferroptosis.Methods:Established human lung fibroblasts MRC-5,WI38,and human LUAD H1650,PC9,H1975,H358,A549,and H1299 cell lines,tumor and matched normal adjacent tissues of LUAD,and plasma from healthy individuals and LUAD patients were used in this study.Immunohistochemistry and immunoblotting were used to analyze protein expression,and quantitative reverse transcription-PCR was used to analyze mRNA expression.Cell viability,cell death,and the lipid reactive oxygen species generationwere measured to evaluate the responses to ferroptosis.Exosomes were observed using transmission electron microscope.The localization of arachidonic acid(AA)was detected using click chemistry labeling followed by confocal microscopy.Interactions between RNAs and proteins were detected using RNA pull-down,RNA immunoprecipitation and photoactivatable ribonucleoside-enhanced crosslinking and immunoprecipitation methods.Proteomic analysis was used to investigate RNA-regulated proteins,and metabolomic analysis was performed to analyze metabolites.Cellderived xenograft,patient-derived xenograft,cell-implanted intrapulmonary LUAD mouse models and plasma/tissue specimens from LUAD patients were used to validate the molecular mechanism.Results:Plasma exosome from LUAD patients specifically reduced lipid peroxidation and desensitized LUAD cells to ferroptosis.A potential explanation is that exosomal circRNA_101093(cir93)maintained an elevation in intracellular cir93 in LUAD to modulate AA,a poly-unsaturated fatty acid critical for ferroptosisassociated increased peroxidation in the plasma membrane.Mechanistically,cir93 interacted with and increased fatty acid-binding protein 3(FABP3),which transported AA and facilitated its reaction with taurine.Thus,global AA was reduced,whereas N-arachidonoyl taurine(NAT,the product of AA and taurine)was induced.Notably,the role of NAT in suppressing AA incorporation into the plasma membrane was also revealed.In pre-clinical in vivo models,reducing exosome improved ferroptosis-based treatment.Conclusion:Exosome and cir93 are essential for desensitizing LUAD cells to ferroptosis,and blocking exosome may be helpful for future LUAD treatment. | Xiao Zhang Yunhua Xu Lifang Ma Keke Yu Yongjie Niu Xin Xu Yi Shi Susu Guo Xiangfei Xue Yikun Wang Shiyu Qiu Jiangtao Cui Hong Wang Xiaoting Tian Yayou Miao Fanyu Meng Yongxia Qiao Yongchun Yu Jiayi Wang | 2022 | Cancer Communications2022，42，4： | 10 |
| 7 | Transfer matrix method for multibody systems(Rui method) and its applications显示文摘The transfer matrix method for multibody systems, namely the 'Rui method', is a new method for studying multibody system dynamics, which avoids the global dynamics equations of the system, keeps high computational speed, and allows highly formalized programming. It has been widely applied to scientific research and key engineering of lots of complex mechanical systems in 52 research directions. The following aspects regarding the transfer matrix method for multibody systems are reviewed systematically in this paper: history, basic principles, formulas, algorithm, automatic deduction theorem of overall transfer equation, visualized simulation and design software, highlights, tendency, and applications in 52 research directions in over 100 key engineering products. | RUI XiaoTing WANG Xun ZHOU QinBo ZHANG JianShu | 2019 | Science China(Technological Sciences)2019，62，5： | 8 |
| 8 | TRPC6在人良性与恶性前列腺组织中的表达显示文摘观察瞬时受体电位通道C6(TRPC6)在人良性与恶性前列腺组织及前列腺癌细胞系中的表达,进一步探讨TRPC6的表达与前列腺癌分期、分级及激素依赖性的关系。利用免疫组织化学技术,检测发现45.0%的前列腺增生和86.6%的前列腺癌病例表达TRPC6,两者比较有显著性差异沪〈0.01)。TRPC6的表达与前列腺癌分级和前列腺外转移有关(P〈0.01)。前列腺癌分期增高,TRPC6表达增多,但在T2、T3和DT4期肿瘤病例中,TRPC6表达无显著差异。此外TRPC6在激素依赖性前列腺癌与激素非依赖性前列腺癌中的表达也无显著差异。应用RT-PCR及Westernblot,检测到TRPC6在前列腺癌细胞系中的表达。本研究发现,TRPC6在良性与恶性前列腺组织及前列腺癌细胞系中表达。TRPC6的表达与前列腺癌的组织分级、Gleason评分及前列腺外转移有关。 | Dan Yue Yong Wang Jian-Ying Xiaot Ping Wang Chang-Shan Ren | 2009 | Asian Journal of Andrology2009，11，5： | 8 |
| 9 | Preparation of Ultrafine TATB and the Technology for Crystal Morphology Control显示文摘极其细小的 1,3,5-triamino-2,4,6-trinitrobenzene (TATB ) 被在与象表面活化剂的范畴和剂量那样的谷物尺寸和晶体形态学控制的靠近的关系中使用溶剂和非溶剂方法,和影响因素准备了,到非溶剂的溶剂的卷比率也在这份报纸被考虑了。它证明这些因素在结晶化过程期间在水晶形态学,粒子尺寸和凝块上有显著效果。由使用 0.095%( 集体百分比) 离子的表面活化剂(S) 作为添加剂并且用作为落下的设备喂设备的水花落下, 1.06 g TATB 原料从 30 ~ 50 nm 与谷物尺寸被精制了进免费跑的椭圆体和球形的 TATB 谷物。由使用 0.014%( 集体百分比) 是的非离子的表面活化剂(P) 添加剂,有 50 nm 的粒子直径并且与狭窄的粒子尺寸分发的球形的 TATB 谷物也被获得了。它被 TATB 的极其细小的粒子最好加热抵抗平均和它的 5 秒点火点的描述显示出被 7.5 K 推进。 | Yang,Li Ren,Xiaoting Li,Tiecheng Wang,Shiwei Zhang,Tonglai | 2012 | Chinese Journal of Chemistry2012，30，2： | 8 |
| 10 | A readily monitored and controllable hydrothermal system for the facile,cost-effective transformation of FGD gypsum to calcium sulfate hemihydrate whiskers显示文摘The controllable transformation of flue gas desulfurization(FGD)gypsum to calcium sulfate hemihydrate(HH)whiskers under facile,readily monitored,and cost-effective hydrothermal conditions could play a vital role in the preparation of high quality HH whiskers and improve our understanding of the transformation process.This work assessed the conversion of FGD gypsum to HH whiskers in 5×10^(-4)mol/L H_(2)SO_(4)and 1.5 wt%CuCl_(2)at 120℃while determining the effects of temperature as well as H_(2)SO_(4)and CuCl_(2)concentrations on transformation kinetics.The preparation of HH whiskers was found to involve a solution-mediated transformation from the dihydrate(DH)to theα-HH.This transition was determined to proceed via a dissolution crystallization mechanism,the rate of which was controlled by nucleation and growth of the HH whiskers.An autocatalytic kinetic model was established based on variations in the HH whiskers mole fraction over time,and this model accurately fit the experimental data with R2=0.990.Increasing the temperature or H_(2)SO_(4)concentration accelerated the transformation by modifying the super-saturation and water activity in the reaction solution,while increasing the CuCl_(2)concentration had the opposite effect.The hydrothermal conditions had an important effect on the transformation from FGD gypsum to HH whiskers. | Bolun Cao Xiao Wang Xiaoting Zhang Biao Jin Zhuoyue Xu Xueping Liu Wei Zhang Liushuan Yang | 2021 | Particuology2021，19，1： | 8 |
| 11 | Dynamic-Change Laws of the Porosity and Permeability of Low-to Medium-Rank Coals under Heating and Pressurization Treatments in the Eastern Junggar Basin,China显示文摘Deep coalbed methane exists in high-temperature and high-pressure reservoirs. To elucidate the dynamic-change laws of the deep coal reservoir porosity and permeability characteristics in the process of coalbed methane production, based on three pieces of low-to medium-rank coal samples in the eastern Junggar Basin, Xinjiang, we analyse their mercury-injection pore structures. We measured the porosity and permeability of the coal samples at various temperatures and confining pressures by high-temperature and confining pressure testing. The results show that the porosity of a coal sample decreases exponentially with increasing effective stress. With increasing temperature, the initial porosity increases for two pieces of relatively low-rank coal samples. The increased rate of porosity decreases with increasing confining pressure. With increasing temperature, the initial porosity of a relatively high-rank coal sample decreases, and the rate of change of the porosity become faster. An exponential relationship exists between the porosity and permeability. With increasing coal rank, the initial porosity and permeability decrease. The change rate of the permeability decreases with increasing porosity. | Gang Wang Yong Qin Jian Shen Shuyuan Chen Beibei Han Xiaoting Zhou | 2018 | Journal of Earth Science2018，29，3： | 8 |
| 12 | Structural characteristic and formation mechanism of hemihydrate calcium sulfate whiskers prepared using FGD gypsum显示文摘Hemihydrate calcium sulfate whiskers(HH-CSWs)were hydrothermally synthesized in a sulfuric acid solution at 120℃ for different holding times(20,40,and 60 min).The phase structures and morphologies were characterized by XRD and SEM,respectively.The XRD pattern of the sample under 60 min was refined via the Rietveld fitting method.The structure models of the HH-CSW sample under a 60-min holding time was established based on Rietveld fitting results.No difference in the positions of diffraction peaks was determined.The as-prepared holding time increased the intensity and aspect ratio of the diffraction peaks of both samples.In the prepared HH-CSW structure,Ca-O polyhedron is a 12-sided polyhedron similar to that in the gypsum structure;the Ca atom is located in two positions in the one-unit cell;the H_(2)O channel along the c-axis similar is O-shaped and bigger than that in hexagonal and monoclinic CaSO_(4)·0.5H_(2)O structures.Therefore,although the prepared HH-CSW crystals’structure are similar to that of the reported hexagonal and monoclinic CaSO_(4)·0.5H_(2)O structures,they are not the same.The formation mechanism of HH-CSW from flue gas desulfurization(FGD)gypsum is discussed based on the analysis of gypsum structure. | Xiaoting Zhang Lingwei Ran Xiao Wang Biao Jin Jianwu Zhang Shanying Li Liushuan Yang | 2022 | Particuology2022，20，3： | 7 |
| 13 | 多器官床旁即时超声在新型冠状病毒肺炎中的应用:国际专家共识显示文摘新型冠状病毒肺炎(简称新冠肺炎,COVID-19)自首次报道以来,已造成全球超一亿人感染,给各国的公共卫生体系造成了巨大威胁。新冠肺炎的临床表现以呼吸系统体征和症状为主,80%的患者症状轻微,约5%为危重症患者,常表现为急性呼吸窘迫综合征(ARDS)。前期,由于缺乏相关研究,面对日益紧迫的临床困境,医务人员不得不借鉴采取一些经验性措施以应对疫情。 | 王臻(译) Arif Hussain Gabriele Via Lawrence Melniker Alberto Goffi Guido Tavazzi Luca Neri Tomas Villen Richard Hoppmann Francesco Mojoli Vicki Noble Laurent Zieleskiewicz Pablo Blanco Irene W.Y.Ma Mahathar Abd.Wahab Abdulmohsen Alsaawi Majid AI Salamah Martin Balik Diego Barca Karim Bendjelid Belaid Bouhemad Pablo Bravo-Figueroa Raoul Breitkreutz Juan Calderon Jim Connolly Roberto Copetti Francesco Corradi Anthony J.Dean AndréDenault Deepak Govil Carmela Graci Young-Rock Ha Laura Hurtado Toru Kameda Michael Lanspa Christian B Laursen Francis Lee Rachel Liu Massimiliano Meineri Miguel Montorfano Peiman Nazerian Bret P.Nelson Aleksandar N.Neskovic Ramon Nogue Adi Osman JoséPazeli Elmo Pereira-Junior Tomislav Petrovic Emanuele Pivetta Jan Poelaert Susanna Price Gregor Prosen Shalim Rodriguez Philippe Rola Colin Royse Yale Tung Chen Mike Wells Adrian Wong Wang Xiaoting Wang Zhen Yaseen Arabi | 2021 | 中国呼吸与危重监护杂志2021，20，2： | 5 |
| 14 | Discrete time transfer matrix method for dynamics analysis of complex weapon systems显示文摘Efficient, precise dynamic modeling and analysis for complex weapon systems have become more and more important in their dynamic design and performance optimizing. As a new method developed in recent years, the discrete time transfer matrix method of multibody system is highly efficient for multibody system dynamics. In this paper, taking a shipboard gun system as an example, by deducing some new transfer equations of elements, the discrete time transfer matrix method of multibody sys- tem is used to solve the dynamics problems of complex rigid-flexible coupling weapon systems successfully. This method does not need the global dynamic equations of system and has the low order of system matrix, high computational efficiency. The proposed method has advantages for dynamic design of complex weapon systems, and can be carried over straightforwardly to other complex mechanical systems. | RUI XiaoTing RONG Bao WANG GuoPing HE Bin | 2011 | Science China(Technological Sciences)2011，54，5： | 5 |
| 15 | Spatiotemporal variation in leaf size and shape in response to climate显示文摘叶片的形态变异是研究植物响应气候变化的重要指标之一。叶片大小与形状影响着植物与外界环境的碳、水等物质交换和能量交换。然而,叶片大小与形状如何响应气候变化仍缺乏研究。此外,大多研究忽略了叶大小与形状在时间和空间上的种内变异,而只关注种间变异。我们收集了中国98年(1910-2008年)7个代表性双子叶植物的植物标本馆标本6000多份,并测量了它们叶片的叶长和宽度。我们探索了叶片大小(叶长、叶宽和长×宽乘积)的地理模式和时间趋势,即研究了降水量和温度随时间和空间的变化对叶片大小和形状变化的影响。在控制了标本采集时间的影响后,全部物种的平均叶大小沿着纬度梯度的增加而减小,但这一关系在不同物种间存在差异。叶大小和形状的空间变异与温度和降水正相关。当控制了采集地点的影响后,全部物种的平均叶大小随着时间有变大的趋势。大多数物种叶大小的时间变化与降水正相关,而叶形状的时间变化则与温度正相关。我们的研究指出叶大小和形状在时空上的种内变异显著受气候的影响,同时说明植物标本可以为研究植物形态对气候变化的响应提供素材。 | Yaoqi Li Dongting Zou Nawal Shrestha Xiaoting Xu Qinggang Wang Wen Jia Zhiheng Wang | 2020 | Journal of Plant Ecology2020，13，1： | 4 |
| 16 | An antioxidant system through conjugating superoxide dismutase onto metal-organic framework for cardiac repair显示文摘Acute myocardial infarction(AMI)remains a dominant origin of morbidity,mortality and disability worldwide.Increases in reactive oxygen species(ROS)are key contributor to excessive cardiac injury after AMI.Here we developed an immobilized enzyme with Superoxide Dismutase(SOD)activity cross-link with Zr-based metal-organic framework(ZrMOF)(SOD-ZrMOF)for mitigate ROS-caused injury.In vitro and in vivo evidence indicates that SOD-ZrMOF exhibits excellent biocompatibility.By efficiently scavenging ROS and suppressing oxidative stress,SOD-ZrMOF can protect the function of mitochondria,reduce cell death and alleviate inflammation.More excitingly,long-term study using an animal model of AMI demonstrated that SOD-ZrMOF can reduce the infarct area,protect cardiac function,promote angiogenesis and inhibit pathological myocardial remodeling.Therefore,SOD-ZrMOF holds great potential as an efficacious and safe nanomaterial treatment for AMI. | Jiacheng Guo Zhenzhen Yang Yongzheng Lu Chunyan Du Chang Cao Bo Wang Xiaoting Yue Zenglei Zhang Yanyan Xu Zhen Qin Tingting Huang Wei Wang Wei Jiang Jinying Zhang Junnan Tang | 2022 | Bioactive Materials2022，7，4： | 4 |
| 17 | Network pharmacological prediction and molecular docking analysis of the combination of Atractylodes macrocephala Koidz.and Paeonia lactiflora Pall.in the treatment of functional constipation and its verification显示文摘Background:We aimed to reveal the mechanism of functional constipation in the treatment of Atractylodes macrocephala Koidz.(AMK)and Paeonia lactiflora Pall.(PLP).Methods:The main active ingredients of AMK and PLP were screened by the Traditional Chinese Medicine Systems Pharmacology(TCMSP)platform.A database of functional constipation targets was established by GeneCard and OMIM.An“ingredient-target”network map was constructed with Cytoscape software(version 3.7.1),and molecular docking analysis was performed on the components and genes with the highest scores.The rats in the normal group were given saline,and those in the other groups were given 10 mg/kg diphenoxylate once a day for 14 days.The serum and intestinal tissue levels of adenosine monophosphate(cAMP),protein kinase A(PKA),and adenylyl cyclase(AC)of the rats and aquaporin(AQP)1,AQP3,and AQP8 were measured.Results:AMK and PLP had a significant role in the regulation of targets in the treatment of functional constipation.After treatment with AMK,PLP,or mosapride,the serum and intestinal tissue levels of AC,cAMP,and PKA were significantly downregulated.Groups receiving AMK and PLP or mosapride exhibited a reduction in the level of AQP1,AQP3,and AQP8 to varying degrees.Conclusion:Molecular docking analysis revealed that AMK and PLP had a significant role in the regulation of targets in the treatment of functional constipation.Studies have confirmed that AMK and PLP can also affect AC,cAMP,and PKA.AC,cAMP,and PKA in model rats were significantly downregulated.AQP expression is closely related to AC,cAMP,and PKA.AMK and PLP can reduce the expression of AQP1,AQP3,and AQP9 in the colon of constipated rats. | Yuxiao Meng Xiaojun Li Xiaoting Wang Lu Zhang Jiaqi Guan | 2022 | Animal Models and Experimental Medicine2022，5，2： | 4 |
| 18 | Glycyrrhetinic acid-modified nanoparticles for drug delivery: Preparation and characterization显示文摘In this work, glycyrrhetinic acid-modified chitosan (mGA-suc-CTS) used as liver targeted carrier for drug delivery, was prepared via hemisuccinate as a bridged group. The structure of the product was confirmed by IR and NMR methods and the degree of substitution (DS) of glycyrrhetinic acid groups was estimated via elemental analysis. Nanoparticles were formed by ionic gelation methold. The drug-loading and release behavior of the nanoparticles were investigated using BSA as the model drug. The results indicated that the carrier with a highest DS of 5.19% could be got and the DS was controlled by changing reaction temperature or feed ratio. BSA could be entrapped into the nanoparticles with the drug-loading ratio of 26.3% and the encapsulation efficiency of 81.5%. A sustained release over an 11-day period was observed in pH 7.4 in vitro. | TIAN Qin WANG Wei HE XiaoTing ZHU XiaoCui HUANG Wei ZHANG ChuangNian YUAN Zhi CHEN XueSi | 2009 | Chinese Science Bulletin2009，54，18： | 4 |
| 19 | Local inhibition of GABA affects precedence effect in the inferior colliculus显示文摘The precedence effect is a prerequisite for faithful sound localization in a complex auditory environment,and is a physiological phenomenon in which the auditory system selectively suppresses the directional information from echoes.Here we investigated how neurons in the inferior colliculus respond to the paired sounds that produce precedence-effect illusions,and whether their firing behavior can be modulated through inhibition with gamma-aminobutyric acid(GABA).We recorded extracellularly from 36 neurons in rat inferior colliculus under three conditions: no injection,injection with saline,and injection with gamma-aminobutyric acid.The paired sounds that produced precedence effects were two identical 4-ms noise bursts,which were delivered contralaterally or ipsilaterally to the recording site.The normalized neural responses were measured as a function of different inter-stimulus delays and half-maximal interstimulus delays were acquired.Neuronal responses to the lagging sounds were weak when the inter-stimulus delay was short,but increased gradually as the delay was lengthened.Saline injection produced no changes in neural responses,but after local gamma-aminobutyric acid application,responses to the lagging stimulus were suppressed.Application of gamma-aminobutyric acid affected the normalized response to lagging sounds,independently of whether they or the paired sounds were contralateral or ipsilateral to the recording site.These observations suggest that local inhibition by gamma-aminobutyric acid in the rat inferior colliculus shapes the neural responses to lagging sounds,and modulates the precedence effect. | Yanjun Wang Ningyu Wang Dan Wang Jun Jia Jinfeng Liu Yan Xie Xiaohui Wen Xiaoting Li | 2014 | Neural Regeneration Research2014，9，4： | 4 |
| 20 | Serum semaphorin 4C as a diagnostic biomarker in breast cancer:A multicenter retrospective study显示文摘Background:To date,there is no approved blood-based biomarker for breast cancer detection.Herein,we aimed to assess semaphorin 4C(SEMA4C),a pivotal protein involved in breast cancer progression,as a serum diagnostic biomarker.Methods:We included 6,213 consecutive inpatients from Tongji Hospital,Qilu Hospital,and Hubei Cancer Hospital.Training cohort and two validation cohorts were introduced for diagnostic exploration and validation.A pan-cancer cohort was used to independently explore the diagnostic potential of SEMA4C among solid tumors.Breast cancer patients who underwent mass excision prior to modified radical mastectomy were also analyzed.We hypothesized that increased pretreatment serum SEMA4C levels,measured using optimized in-house enzymelinked immunosorbent assay kits,could detect breast cancer.The endpoints were diagnostic performance,including area under the receiver operating characteristic curve(AUC),sensitivity,and specificity.Post-surgery pathological diagnosis was the reference standard and breast cancer staging followed the TNM classification.There was no restriction on disease stage for eligibilities.Results:We included 2667 inpatients with breast lesions,2378 patients with other solid tumors,and 1168 healthy participants.Specifically,118 patients with breast cancer were diagnosed with stage 0(5.71%),620 with stage I(30.00%),966 with stage II(46.73%),217 with stage III(10.50%),and 8 with stage IV(0.39%).Patients with breast cancer had significantly higher serum SEMA4C levels than benign breast tumor patients and normal controls(P<0.001).Elevated serum SEMA4C levels had AUC of 0.920(95%confidence interval[CI]:0.900–0.941)and 0.932(95%CI:0.911–0.953)for breast cancer detection in the two validation cohorts.The AUCs for detecting early-stage breast cancer(n=366)and ductal carcinoma in situ(n=85)were 0.931(95%CI:0.916–0.946)and 0.879(95%CI:0.832–0.925),respectively.Serum SEMA4C levels significantly decreased after surgery,and the reduction was more striking after modified radical mastectomy,compared with mass excision(P<0.001).The positive rate of enhanced serum SEMA4C levels was 84.77%for breast cancer and below 20.75%for the other 14 solid tumors.Conclusions:Serum SEMA4C demonstrated promising potential as a candidate biomarker for breast cancer diagnosis.However,validation in prospective settings and by other study groups is warranted. | Ya Wang Long Qiao Jie Yang Xiong Li Yaqi Duan Jiahao Liu Shaoqi Chen Huayi Li Dan Liu Tian Fang Jingjing Ma Xiaoting Li Fei Ye Junxiang Wan Juncheng Wei Qin Xu Ensong Guo Ping Jin Mingfu Wu Lin Zhang Yun Xia Yaqun Wu Jun Shao Yaojun Feng Qing Zhang Zongyuan Yang Gang Chen Qinghua Zhang Xingrui Li Shixuan Wang Junbo Hu Xiaoyun Wang Mona P.Tan Kazuaki Takabe Beihua Kong Qifeng Yang Ding Ma Qinglei Gao | 2021 | Cancer Communications2021，41，12： | 3 |
您所在的机构暂未开通此部分的功能，请联系管理员