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| 1 | Release of interleukin-10 and neurotrophic factors in the choroid plexus:possible inductors of neurogenesis following copolymer-1 immunization after cerebral ischemia显示文摘Copolymer-1(Cop-1) is a peptide with immunomodulatory properties, approved by the Food and Drug Administration of United States in the treatment of multiple sclerosis. Cop-1 has been shown to exert neuroprotective effects and induce neurogenesis in cerebral ischemia models. Nevertheless, the mechanism involved in the neurogenic action of this compound remains unknown. The choroid plexus(CP) is a network of cells that constitute the interphase between the immune and central nervous systems, with the ability to mediate neurogenesis through the release of cytokines and growth factors. Therefore, the CP could play a role in Cop-1-induced neurogenesis. In order to determine the participation of the CP in the induction of neurogenesis after Cop-1 immunization, we evaluated the gene expression of various growth factors(brain-derived neurotrophic factor, insulin-like growth factor 1, neurotrophin-3) and cytokines(tumor necrosis factor alpha, interferon-gamma, interleukin-4(IL-4), IL-10 and IL-17), in the CP at 14 days after ischemia. Furthermore, we analyzed the correlation between the expression of these genes and neurogenesis. Our results showed that Cop-1 was capable of stimulating an upregulation in the expression of the genes encoding for brain-derived neurotrophic factor, insulin-like growth factor 1, neurotrophin-3 and IL-10 in the CP, which correlated with an increase in neurogenesis in the subventricular and subgranular zone. As well, we observed a downregulation of IL-17 gene expression. This study demonstrates the effect of Cop-1 on the expression of growth factors and IL-10 in the CP, in the same way, presents a possible mechanism involved in the neurogenic effect of Cop-1. | Yolanda Cruz Edna E.García Jessica V.Gálvez Stella V.Arias-Santiago Horacio G.Carvajal Raúl Silva-García Herlinda Bonilla-Jaime Julio Rojas-Castaneda Antonio Ibarra | 2018 | Neural Regeneration Research2018，13，10： | 7 |
| 2 | Treatment of chronic hepatitis C with direct-acting antivirals: The role of resistance显示文摘The use of direct-acting antivirals(DAAs) to treat chronic hepatitis C has resulted in a significant increase in rates of sustained viral response(around 90%-95%) as compared with the standard treatment of peginterferon/ribavirin. Despite this, however, the rates of therapeutic failure in daily clinical practice range from 10%-15%. Most of these cases are due to the presence of resistant viral variants, resulting from mutations produced by substitutions of amino acids in the viral target protein that reduce viral sensitivity to DAAs, thus limiting the efficacy of these drugs. The high genetic diversity of hepatitis C virus has resulted in the existence of resistance-associated variants(RAVs), sometimes even before starting treatment with DAAs, though generally at low levels. These preexisting RAVs do not appear to impact on the sustained viral response, whereas those that appear after DAA therapy could well be determinant in virological failure with future treatments. As well as the presence of RAVs, virological failure to treatment with DAAs is generally associated with other factors related with a poor response, such as the degree of fibrosis, the response to previous therapy, the viral load or the viral genotype. Nonetheless, viral breakthrough and relapse can still occur in the absence of detectable RAVs and after the use of highly effective DAAs, so that the true clinical impact of the presence of RAVs in therapeutic failure remains to be determined. | Miguel Jiménez-Pérez Rocío González-Grande Pilar Espana Contreras Isabel Pinazo Martínez Jesús de la Cruz Lombardo Raúl Olmedo Martín | 2016 | World Journal of Gastroenterology2016，22，29： | 3 |
| 3 | Insulin resistance impairs sustained response rate to peginterferon plus ribavirin in chronic hepatitis C patients显示文摘 | Manuel Romero-Gómez Maria Del Mar Viloria Raúl J. Andrade Javier Salmerón Moisés Diago Conrado M. Fernández-Rodríguez Raquel Corpas Marina Cruz Lourdes Grande Luis Vázquez Paloma Mu?oz-de-Rueda Pilar López-Serrano Ana Gila María L. Gutiérrez Celia Pérez A | 2005 | Gastroenterology2005，，3： | 2 |
| 4 | Novel mutation in sonic hedgehog in non-syndromic colobomatous microphthalmia显示文摘 | Schimmenti LA de la Cruz J Lewis RA | 2003 | Am J Med Genet2003，116，： | 1 |
| 5 | CD40-targeted dendritic cell delivery of PLGA-nanoparticle vaccines induce potent anti- tumor responses显示文摘 | Rosalia RA Cruz LJ Duikeren SV | 2015 | Biomaterials2015，40，： | 1 |
| 6 | Periorificial dermatitis in children: an update and description of a child with strik- ing features显示文摘 | Kihiczak GG Cruz MA SChwartz RA | 2009 | International journal of dermatology2009，48，3： | 1 |
| 7 | Herbaspirillum-plant interactions: microscopical, histological and molecular aspects 显示文摘 | Monteiro RA Balsanelli E Wassem R Marin AM Brusamarello- Santos LCC Schmidt MA Tadra-Sfeir MZ Pankievicz VCS Cruz LM Chubatsu LS Pedrosa FO Souza EM | 2012 | Plant Soil2012，356，12： | 1 |
| 8 | Thymosin-beta (4) changes the conformation and dynamics of action monomers 显示文摘 | Dela Cruz EM Ostap EM Brundage RA | 2000 | Biophys J2000，78，5： | 1 |
| 9 | Differences in car- diopulmonary exercise test results by American Thoracic Society/ European Respiratory Society - Global Initiative for Chronic Ob- structive Lung Disease stage categories and gender 显示文摘 | Pinto - Plata VM Celli - Cruz RA Vassaux C | 2007 | Chest2007，132，4： | 1 |
| 10 | Antibodies to carbonic anhydrase in endometriosis:prevalence,specificity,and relationship to clinical and laboratory parameters显示文摘 | D'Cruz OJ Wild RA Hass GG | 1996 | Fertil Steril1996，66，4： | 1 |
| 11 | Lung cancer: epidemiology, etiology,and prevention显示文摘 | Dela Cruz CS Tanoue LT Matt hay RA | 2011 | Clin Chest Med2011，32，4： | 1 |
| 12 | Lung cancer: epidemiology,etiology, and prevention显示文摘 | Dela Cruz CS Tanoue LT Matthay RA | 2011 | Clin Chest Med2011，32，4： | 1 |
| 13 | Clinical effect and mechanism of cariostatic action of fluoride-containing toothpastes:a review显示文摘 | Oaard B Cruz RA | 1991 | Int Dent J1991，41，： | 1 |
| 14 | Effects of excess dietary iodine upon pullets and laying hens显示文摘 | Arrington LR Santo - Cruz RA Harms RJ | 1967 | J Nutr1967，92，： | 1 |
| 15 | Temporal andspatial asymmetries in the initial distribution of mesenchyme cells inthe atrioventricular canal cushions of the developing chick heart显示文摘 | Moreno-Rodriguez RA de la Cruz MV Krug EL | 1997 | Anat Rec1997，248，1： | 1 |
| 16 | Antibodies to carbonic anhydrase in endonmetriosis: prevalence, specificity, and relationship to clinical and laboratory parameters 显示文摘 | / Cruz OJ Wild RA Hass GG | 1996 | Fertil Steril1996，66，： | 1 |
| 17 | Prospective,randomized,con-trolled clini- cal trial of a novelmatrix hemostatic sealant inchildren undergo- ing adenoidectomy显示文摘 | Mathiasen RA Cruz RM | 2004 | Otolaryngol Head Neck Surg2004，131，5： | 1 |
| 18 | Lung cancer:Epidemiology,etiology,and prevention显示文摘 | Dela Cruz CS Tanoue LT Matthay RA | 2011 | Clin Chest Med2011，32，4： | 1 |
| 19 | Lung cancer: epi- demiology, etiology, and prevention显示文摘 | Dela Cruz C S Tanoue L T Matthay RA | 2011 | Clinics in chest medicine2011，32，4： | 1 |
| 20 | Prospective, randomized, controlled clinical trial of a novel matrix hemostatie sealant in children undergoing edenoideetomy 显示文摘 | Mathiasen RA Cruz R | 2004 | Laryngoscope2004，131，5： | 1 |
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