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| 1 | Chromodomain-helicase-DNA binding protein 5, 7 and pronecrotic mixed lineage kinase domain-like protein serve as potential prognostic biomarkers in patients with resected pancreatic adenocarcinomas显示文摘Pancreatic cancer is one of the deadliest cancers with a very poor prognosis. Recently, there has been a significant increase in research directed towards identifying potential biomarkers that can be used to diagnose and provide prognostic information for pancreatic cancer. These markers can be used clinically to optimize and personalize therapy for individual patients. In this review, we focused on 3 biomarkers involved in the DNA damage response pathway and the necroptosis pathway: Chromodomainhelicase-DNA binding protein 5, chromodomain-helicaseDNA binding protein 7, and mixed lineage kinase domain-like protein. The aim of this article is to review present literature provided for these biomarkers and current studies in which their effectiveness as prognostic biomarkers are analyzed in order to determine their future use as biomarkers in clinical medicine. Based on the data presented, these biomarkers warrant further investigation,and should be validated in future studies. | Crystal S Seldon Lauren E Colbert William A Hall Sarah B Fisher David S Yu Jerome C Landry | 2016 | World Journal of Gastrointestinal Oncology2016，8，4： | 2 |
| 2 | Immune checkpoint molecules in natural killer cells as potential targets for cancer immunotherapy显示文摘Recent studies have demonstrated the potential of natural killer(NK)cells in immunotherapy to treat multiple types of cancer.NK cells are innate lymphoid cells that play essential roles in tumor surveillance and control that efficiently kill the tumor and do not require the major histocompatibility complex.The discovery of the NK’s potential as a promising therapeutic target for cancer is a relief to oncologists as they face the challenge of increased chemo-resistant cancers.NK cells show great potential against solid and hematologic tumors and have progressively shown promise as a therapeutic target for cancer immunotherapy.The effector role of these cells is reliant on the balance of inhibitory and activating signals.Understanding the role of various immune checkpoint molecules in the exhaustion and impairment of NK cells when their inhibitory receptors are excessively expressed is particularly important in cancer immunotherapy studies and clinical implementation.Emerging immune checkpoint receptors and molecules have been found to mediate NK cell dysfunction in the tumor microenvironment;this has brought up the need to explore further additional NK cell-related immune checkpoints that may be exploited to enhance the immune response to refractory cancers.Accordingly,this review will focus on the recent findings concerning the roles of immune checkpoint molecules and receptors in the regulation of NK cell function,as well as their potential application in tumor immunotherapy. | Yuqing Cao Xiaoyu Wang Tianqiang Jin Yu Tian Chaoliu Dai Crystal Widarma Rui Song Feng Xu | 2020 | Signal Transduction and Targeted Therapy2020，5，1： | 2 |
| 3 | Fullerene C60 exposure elicits an oxidative stress response in embryonic zebrafish 显示文摘 | Crystal YU Stacey LH Robert LT | 2008 | Toxicology and Applied Pharmacology2008，229，： | 1 |
| 4 | Synthesis, Structure and Non-linear Optical Properties of Manganese Mercury Tetrathiocyanate显示文摘IntroductionRecently,ourresearchinterestshavefocusedonMHg(SCN).seriesofcrystallinecomplexesbecauseoftheirstrikingnonlinearopticalproperties.Inthepreviouspaper'',wehavereporedthesynthesis.structureandnonlinearoptical(NLO)propertiesofCdHg(SCN).andFeHg... | Yun Xing YAN Qi FANG Duo Rong YUAN Yu Peng TIAN Zhi LIU Xiao MeiWANG Min Hua JIANG D. WILLIAMS A. SIU Zhi Gang CAI (Institute of Crystal Materials and State Key Laboratory of Crystal Materials,Shandong University. Jinan 250100)(Department of Chem | 1999 | Chinese Chemical Letters1999，10，3： | 1 |
| 5 | Theory Study on Structures and Vibrational Frequencies of Pyruvic acid显示文摘Density functional theory BLYP (using Becke’s and Lee-Yang-Pars’s correlation functionals), ab initio Hartree-Fock (HF) and hybrid DFT/HF B3LYP calculations were carried out to study the structure and vibrational spectra of pyruvic acid. The scaled B3LYP/6-31G* frequencies correspond well with available experimental assignment of the functional vibrational modes and the mean absolut devation is only 12.3cm-1. | Dong Met DU Ai Ping FU Zheng Yu ZHOU (Department of Chemistry. Qufu Normal University. Shandong. Qufu 273165 State Key Laboratory Crystal Materials Shandong University.Shandong. Jinan 250100) | 2000 | Chinese Chemical Letters2000，11，5： | 0 |
| 6 | Synthesis, Structure and Properties of Tetrakis (thiourea) mercury (II) Tetrakis (thiocyanato-N) zinc (II)显示文摘A new nonlinear optical complex crystal tetrakis (thiourea) mercury (II) tetrakis (thiocyanato-N) zinc (II) was synthesized and its structure was determined. It belongs to the tetragonal system, Ispace group. The crystal structure consists of discrete [Zn(SCN)4]2- anions and [Hg(NH2CSNH2)4]2+ cations with slightly distorted coordination tetrahedra ZnN4 and HgS4. The second harmonic generation (SHG) of the crystal was found to be superior to that of urea. | Xue Ning JIANG*, Dong XU, Duo Rong YUAN, Wen Tao YU, Meng Kai LU, Shi Yi GUO, Guang Hui ZHANG, Qi FANG Institute of Crystal Materials and State Key Laboratory of Crystal Materials, Shandong University, Jinan 250100 | 2001 | Chinese Chemical Letters2001，12，3： | 0 |
| 7 | Theoretical Study on the Structure and Vibrational Spectra for 4-methyl-3-penten-2-one显示文摘Density functional theory BLYP (using Becke’s and Lee-Yang-Pars’s correlationfunctionals ). ab initio Hartree-Fock (HF) and hybrid DFT/HF B3LYP calculations were carriedout to study the structure and vibrational spectra of 4-methyl-3-penten-2-one. The BLYP/6-31G*and scaled HF/6-31G* frequencies correspond well with each other and with availableexperimental assignment of the functional vibrational modes. | Dong Mei DU Ai Ping FU Zheng Yu ZHOU (Department of Chemistry. Qufu Normal University, Shandong, Qufu 273165 2 State Key Laboratory of Crystal Materials. Shandong University, Shandong, Jinan 250100) | 1999 | Chinese Chemical Letters1999，10，10： | 0 |
| 8 | Synthesis, Structure and Transesterification of the Derivatives of β-Alkoxycarbonylethyltin Trichlorides with Diethyldithiocarbamate显示文摘The derivatives of β-alkoxycarbonylethyltin trichlorides with diethyldithiocarbamate,ROCOCH2CH2Sn(S2CNEt2)Cl2, were synthesized and characterized by the means of elemental analysis, IR, 1H NMR and X-ray single crystal diffraction. The structural features of the compounds were described, and the possible mechanism of transesterification for compound 2a was suggested. | Lai Jin TIAN Bin ZHAO Zheng Yu ZHOU Min XIA Wen Tao YU Ping YANG(Department of Chemistry, Qufu Normal University, Shandong, Qufu 273165)(State Key Laboratory Crystal Materials Shandong University, Shandong, Jinan 250100) | 2000 | Chinese Chemical Letters2000，11，6： | 0 |
| 9 | DFT Calculations for Electron Transfer Bond-breakingReaction of CH_3-X显示文摘DFT/6-311+g** level calculations are performed to study the electron transfer bond-breaking reaction of CH3-X. The calculated values are in good agreement with the experimental results or the empirical model. Through analyzing the change of the energy and the charge density along the reaction path, the bond-breaking in ET reaction for CH3X is investigated. | Yu Mei XING2, Zheng Yu ZHOU1,3*, Ben Ni DU1 1Department of Chemistry, Qufu Normal University, Shandong Qufu 273165 2Department of Chemistry, Nankai University, Tianjin 300071 3State Key Laboratory of Crystal Materials, Shandong University, Shandong, Jina | 2001 | Chinese Chemical Letters2001，12，4： | 0 |
| 10 | Synthesis and Structure of 3-Trichlorostannylpropionate Complexes with Dibutylsulfoxide and Pyridine Oxide显示文摘A series of 3 -trichlorostannylpropionate complexes with dibutylsulfoxide and pyridine oxide were synthesized by transesterification reaction and characterized by means of elemental analysis, IR, NMR(1H,13C) and X-ray single crystal diffraction. | Lai Jin-TIAN Bin ZHAO Zheng Yu ZHOU Wen Tao YU(Department of Chemistry, Qufu Normal Universityi, Qufu, 273165Institute of Crystal Materials, Shandong University, Jinan, 250100) | 1997 | Chinese Chemical Letters1997，8，9： | 0 |
| 11 | Two-photon Pumped Up-conversion Lasing Properties of A Series of Organic Salts with Different Side-chains显示文摘The synthesis and upconverted fluorescent properties of a series of organic compounds with the structure: donor/bridge/acceptor, and different side-chains are reported. The results show that the compounds with different side-chains exhibit different two-photon induced fluorescent properties, although they have the same main donor/bridge/acceptor structure. | Yu Peng TIAN1,2*, Fu Ying HAO1, Jie Ying WU1, Qi FANG3, Min Hua JIANG3 1Department of Chemistry, Anhui University, Hefei 230039 2State Key Laboratory of Coordination Chemistry, Nanjing University 210093 3Institute of Crystal Materials, Shandong Universit | 2001 | Chinese Chemical Letters2001，12，7： | 0 |
| 12 | Analysis of Vibration Mode for H_2+F→HF+H Reaction Mechanism: Density functional Theory Calculation显示文摘Three density functional theory methods (DFT) have been used to investigate the H2+F?HF+H reaction comparing with the Hartree-Fock method and Moller-Plesset (MP2) perturbation theory method. Through the analysis of the vibrational mode and vibrational frequency in the reaction process, the reaction mechanism has been discussed. The activation energy, the reorganization energy and rate constant of the ET reaction are calculated at semi-quantitative level. | Ben Ni DU1, Hong Wei GAO1, Zheng Yu ZHOU1,2*, Wei Chao ZHANG1,3 1Department of Chemistry, Qufu Normal University, Shandong, Qufu 273165 2State Key Laboratory Crystal Materials Shandong University, Shandong, Jinan 250100 3Department of Chemistry, Zaozhuan | 2001 | Chinese Chemical Letters2001，12，8： | 0 |
| 13 | Synthesis,Characterization and Non-linear Optical Properties of a New Organic Dye:DEAHAS显示文摘Trans-4- (N-2-hydroxyethyl-N-ethyl amino)-4ˊ-(diethyl amino)stilbene (DEAHAS) has been synthesized and characterized by 1H NMR, IR and elemental analysis. Linear absorption, single-photon induced fluorescence and two-photon induced fluorescence are experimentally studied. DEAHAS has an effective two-photon absorption cross-sections ofσ2 = 1.19×10-46 cm4·s/photon at 532 nm by using an open aperture Z-scan technique and exhibits a strong two-photon induced blue fluorescence of 430 nm when pumped with 800 nm laser irradiation. | Yun Xing YAN*, Xiao Qiang YU, Dong WANG, Xian ZHAO, Qi FANG, Min Hua JIANG State Key Laboratory of Crystal Materials, Shandong University, Ji抧an 250100 | 2003 | Chinese Chemical Letters2003，14，11： | 0 |
| 14 | Synthesis and Structure of the Complexes of 2-Alkoxycarbonylalkyltin Trichlorides with 2-Salicylideneaminophenol显示文摘The complexes of 2-Alkoxycarbonylalkyltin Trichlorides with 2-Salicylideneamino-phenol have been synthesized and characterized by means of elemental analysis, lR, 1H-NMR andX-ray single crystal diffraction. The structural features of the complexes are described. | Lai Jin TIAN Bin ZHAO Zheng Yu ZHOU(Department of Chernistry, Qufu Normal University, Qufu 273165)Ping YANG Wen Tao YU(Institute of Crystal Materials, Shandong University, Jinan 2250100) | 1998 | Chinese Chemical Letters1998，9，2： | 0 |
| 15 | Synthesis, Structure and Non-linear Optical Properties of Iron Mercury Tetrathiocyanate显示文摘Iron Mercury Tetrathiocyanate (FeHg(SCN)4) has been synthesized and its structure hasbeen detendned. It belongs to the tetragonal system, 14 space group. The Hg-S-C=N-Fe bridgeleeds to the formation of an infinite three dimensional network. Irrsdiated by a 1.064 nm Nd:YAG laser beam, FeHg(SCN)4 showed a 0.532 nm second harmonic intensity which is 0.6 times asthat of organic nonlinear optical crystal urea. | Yun Xing YAN Qi FANG Wen Tao YU Yu Peng TIAN Duo Rong YUAN Xin Qiang WANG Fan Qing MENG (Institute of Crystal Materials and State Key Laboratory of Crystal Materials,Shandong University, Jinan, 250100)Zhi Gang CAI Ling Zhi ZHANG (Institute of Laser | 1998 | Chinese Chemical Letters1998，9，12： | 0 |
| 16 | Metallorganic Vapor Phase Epitaxy of(AlGa)InP on GaAs at Atmospheric Pressure显示文摘High quality (AlGa)InP epilayers lattice matched on GaAs substrates were grown by atmosphericpressure metallorganic vapor phase epitaxy (AP-MOVPE).The relationship between surfacemorphologies and lattice mismatches was studied.The influence of Al incorporation to thephotoluminescence and electronic properties of AlGaInP was measured.The applicability of growthat atmospheric pressure and the passivation of Zn in AlGaInP were discussed. | Hongwen REN Baibiao HUANG Shuqin YU Xian’gang XU Shiwen LIU Minhua JIANG Institute of Crystal Materials,Shandong University,Jinan,250100,China | 1993 | Journal of Materials Science & Technology1993，9，6： | 0 |
| 17 | Large second-order optical nonlinearities of s-triazine derivatives: View from micro molecules to macro crystals显示文摘Three s-triazine derivatives have been synthesized and their structures been de-termined. These are Compound I: 2,4-dimethyl-6-(p-N,N-dimethylaminostyryl)-s-triazine (abbre-viated to NMe-1), Compound II: 2,4-dimethyl-6-(p-N,N-diethylaminostyryl)-s-triazine (to NEt-1), and Compound III: 2-methyl-4,6-bis(p-N,N-dimethylaminostyryl)-s-triazine (NMe-2). NMe-1 and NEt-1 molecules belong to the D-π-A type with a one-dimensional charge-transfer character. NMe-1 crystallizes to centrosymmetric P1 space group, while NEt-1 to non-centrosymmetric polar Cc space group with all of the molecular charge-transfer axes taking the same orientation. Under the irradiation of 1064 nm fundamental laser, NEt-1 powder crystals radiate a 2-order harmonic light with an intensity 46.8 times that of urea. The Λ typed NMe-2 molecule, which has a two-dimensional charge-transfer character, crystallizes to polar P21 space group. Its powder crystals exhibit a 2-order harmonic intensity 46.2 times that of urea. The quantum chemical cal-culations and tensor analyses have been carried out to reveal the dependence of the macro 2-order nonlinear optical (NLO) efficiency on the micro 2-order NLO coefficients (β) and on the crystalline packing styles. | FANG Qi1, LEI Hong2, CUI Yuezhi3, HUANG Zhenli4, XUE Gang1 & YU Wentao1 1. State Key Laboratory of Crystal Materials, Shandong University, Jinan 250100, China 2. School of Information Science and Engineering, Shandong University, Jinan 250100, China 3. Department of Chemical Engineering, Light Industry College of Shandong, Jinan 250100, China 4. Key Laboratory of Biomedical Photonics, Ministry of Education, Huazhong University of Science and Technology, Wuhan 430074, China | 2005 | Science China Chemistry2005，48，3： | 0 |
| 18 | A NEW APPROACH TO ESTIMATE KINETIC DECOMPOSITION FROM TG-DTG OR DSC CURVE显示文摘This paper reports a new approach to estimate kineticparameters for the thermal decomposition of the solid state fromTG-DTG or DSC curve.Reduced equations are derived for the firsttlme.The validity of these equations was demonstrated employingdata obtained from the dehydration process of calcium oxalatemonohydrate. | Yu Ting ZHAO Jian Hua ZHANG Tong Shan SUN Department of Chemistry,Shandong University,Jinan,250100Zhao He YANG Institute of Crystal Materials,Shandong University,Jinan,250100 | 1993 | Chinese Chemical Letters1993，4，6： | 0 |
| 19 | Two-photon Up-conversion Luminescent Properties of HMASPS and HEASPS in Three Different Polymer Matrices显示文摘Three dye-doped polymer rods in different matrices were synthesized in which weak hydrogen bond, strong hydrogen bond and covalent bond existed between the dye and the polymer chain. And the two-photon up-conversion luminescent properties of HMASPS and HEASPS1 in three different microenvironments were studied. | Yan REN, Xiao Qiang YU, Dong WANG, Guang Yong ZHOU, Zhi Qiang LIU, Yu Fang ZHOU, Xian ZHAO, Zong Shu SHAO, Ji Yang WANG, Min Hua JIANG* State Key Laboratory of Crystal Materials, Shandong University, Jinan 250100 | 2002 | Chinese Chemical Letters2002，13，5： | 0 |
| 20 | Recent Development on the Mechanism Research of Crystal Growth显示文摘Recent developments on the research of growth mechanism by two -dimensional nucle-ation, dislocation, normal and three -dimensional nucleation are reviewed: the latest research work on the structure adjusting in the interface boundary layers and the theory model of growth units are also summarized in this paper. | Yu Xiling Wan Yan( The State Key Lab of Crystal Materials of Shandong University, Ji ’nan 250100 Physics Department of Shanghai University, Shanghai 200436) | 2002 | Science Foundation in China2002，10，2： | 0 |
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