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| 1 | Burden of Clostridium difficile infection between 2010 and 2013:Trends and outcomes from an academic center in Eastern Europe显示文摘AIM:To analyze the incidence and possible risk factors in hospitalized patients treated with Clostridium difficile infection(CDI).METHODS:A total of 11751 patients were admitted to our clinic between 1 January 2010 and 1 May2013.Two hundred and forty-seven inpatients were prospectively diagnosed with CDI.For the risk analysis a 1:3 matching was used.Data of 732 patients matched for age,sex,and inpatient care period and unit were compared to those of the CDI population.Inpatient records were collected from an electronic hospital database and comprehensively reviewed.RESULTS:Incidence of CDI was 21.0/1000 admissions(2.1%of all-cause hospitalizations and 4.45%of total inpatient days).The incidence of severe CDI was 12.6%(2.63/1000 of all-cause hospitalizations).Distribution of CDI cases was different according to the unit type,with highest incidence rates in hematology,gastroenterology and nephrology units(32.9,25 and24.6/1000 admissions,respectively) and lowest rates in 1.4%(33/2312) in endocrinology and general internal medicine(14.2 and 16.9/1000 admissions)units.Recurrence of CDI was 11.3%within 12 wk after discharge.Duration of hospital stay was longer in patients with CDI compared to controls(17.6 ± 10.8d vs 12.4 ± 7.71 d).CDI accounted for 6.3%of allinpatient deaths,and 30-d mortality rate was 21.9%(54/247 cases).Risk factors for CDI were antibiotic therapy[including third-generation cephalosporins or fluoroquinolones,odds ratio(OR) = 4.559;P < 0.001],use of proton pump inhibitors(OR = 2.082,P< 0.001),previous hospitaiization within 12 mo(OR = 3.167,P < 0.001),previous CDI(OR = 15.32;P < 0.001),while presence of diabetes mellitus was associated with a decreased risk for CDI(OR = 0.484;P< 0.001).Treatment of recurrent cases was significantly different from primary infections with more frequent use of vancomycin alone or in combination(P < 0.001),and antibiotic therapy duration was longer(P < 0.02).Severity,mortality and outcome of primary infections and relapsing cases did not significantly differ.CONCLUSION:CDI was accounted for significant burden with longer hospitaiization and adverse outcomes.Antibiotic,PPI therapy and previous hospitaiization or CDI were risk factors for CDI. | Zsuzsanna Kurti Barbara D Lovasz Michael D Mandel Zoltan Csima Petra A Golovics Bence D Csako Anna Mohas Lorant Gnczi Krisztina B Gecse Lajos S Kiss Miklos Szathmari Peter L Lakatos | 2015 | World Journal of Gastroenterology2015，21，21： | 6 |
| 2 | Impact of blood collection de- vices on clinical chemistry assays显示文摘 | Bowen RA Hortin GL Csako G | | Clin Biochem0，43，1： | 1 |
| 3 | Lack of association of restenosis f ollowing coronary angioplasty with elevated C-Reactive protein levels or seropo sitivity to chlamydia pneumoniae显示文摘 | Csako G Grayston JT | 1999 | Am J Cardiol1999，84，： | 1 |
| 4 | Relation of fibrinolytic potentiation by estrogen to coagulation pathway activation in postmenopausal women显示文摘 | Koh KK Home MDK Csako G | 1999 | Am J Cardiol1999，83，46： | 1 |
| 5 | Effects of thyroid hormone suppression therapy on adverse clinical outcomes in thyroid cancer显示文摘 | McGriff NJ Csako G Gourgiotis L | 2002 | Ann Med2002，34，78： | 1 |
| 6 | Relevance of macro creatine kinase type 1 and type 2 isoenzymes to laboratory and clinical data 显示文摘 | Kyung N Lee Csako G Bernhardt P | 1994 | Clin Chem1994，40，7： | 1 |
| 7 | Relevance of macro creatine kinase type 1 and type 2 isoenzymes to laboratory and clinical data显示文摘 | Lee KN Csako G Bernhardt P | 1994 | Clin Chem1994，40，71： | 1 |
| 8 | Depression as a risk factor for osteoporosis显示文摘 | Cizza G Primma S Csako G | 2009 | Trends Endocrinol Metab2009，20，： | 1 |
| 9 | Effects of thyroidhormone suppression therapy on adverse clinical outcomesin thyroid cancer显示文摘 | McGriff NJ Csako G Gourgiotis L | 2002 | Ann Med2002，34，78： | 1 |
| 10 | Lack of association of restenosis following coronary angioplasty with elevated C-reactive protein levels or seropositivity to Chlamydia penumoniae 显示文摘 | Zhou YF Csako G Grayston T | 1999 | Am J Cardiol1999，84，： | 1 |
| 11 | Relation of fibrinolytic potentiation by estrogen to coagulation pathway activation in postmenopausal woman显示文摘 | Koh KK Home MK Csako G | 1999 | Am J Cardiol1999，83，： | 1 |
| 12 | Effects of thyroid hormone suppression therapy on adverse clinical outcomes in thyroid cancer显示文摘 | McGriff NJ Csako G Gourgiotis L | 2002 | Ann Med2002，34，78： | 1 |
| 13 | Depression as a risk factor for osteoporosis显示文摘 | Cizza G Primma S Csako G | 2009 | Trends Endocrinol Metab2009，20，8： | 1 |
| 14 | Depression as a risk factor for osteoporosis 显示文摘 | Cizza G Primma S Csako G | 2009 | Trends Endocrinol Metab2009，20，8： | 1 |
| 15 | Increased levothyroxine requirements preseting as'inappropriate' TSH secretion syndrome in a patient with nephrotic syndrome显示文摘 | Collins MT Remaley AT Csako G | 2000 | J Endocrinol Invest2000，23，6： | 1 |
| 16 | Relevance of macro creatine kinase type 1 and type 2 isoenzymes to laboratory and clinical data显示文摘 | Lee KN Csako G Bernhardt P | 1994 | Clin Chem1994，40，71： | 1 |
| 17 | Relevance of macro kinase kinase type 1 and type 2 isoenzymes to laboratory and clinical data 显示文摘 | Lee KN Csako G Bernhardt P | 1994 | Clin Chem1994，40，7： | 1 |
| 18 | Sustained low-grade pro-inflammatory state in unmedicated, remitted Women with major depressive disorder as evidenced by elevated serum levels of the acute phase proteins C-reactive protein and serum amyloid A 显示文摘 | Kling MA Alesci S Csako G | 2007 | Biol Psychiatry2007，62，4： | 1 |
| 19 | Structure,biosynthesis,and function of salivary显示文摘 | Wu AM Csako G Herp A | 1994 | Mol Cell Biochem1994，137，1： | 1 |
| 20 | Cytomegalovirus infection in women is associated with elevated levels of C-reactive protein and coronary artery disease, but susceptibility is modulated by the type of immune response mounted by the host显示文摘 | Quyyumi AA Csako G | 1998 | Circulation1998，98，： | 1 |
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