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| 1 | IL23R single nucleotide polymorphisms could be either beneficial or harmful in ulcerative colitis显示文摘AIM To investigate the association of seven single nucleotide polymorphisms(SNPs) of the IL23 R gene with the clinical picture of ulcerative colitis(UC). METHODS Genomic DNA samples of 131 patients (66 males, 65 females, mean age 55.4 ± 15.8 years) with Caucasian origin, diagnosed with UC were investigated. The diagnosis of UC was based on the established clinical, endoscopic, radiological, and histopathological guidelines. DNA was extracted from peripheral blood leukocytes by routine salting out method. Polymerase chain reaction and restriction fragment length polymorphism were used to identify the alleles of seven SNPs of IL23 R gene(rs11209026, rs10889677, rs1004819, rs2201841, rs7517847, rs10489629, rs7530511).RESULTS Four out of seven analyzed SNPs had statistically significant influence on the clinical picture of UC. Two SNPs were associated with greater colonic extension(rs2201841 P = 0.0084; rs10489629 P = 0.0405). For two of the SNPs, there was more frequently need for operations (rs2201841 P = 0.0348, OR = 8.0; rs10889677 P = 0.0347, OR = 8.0). The rs2201841 showed to be a risk factor for the development of iron deficiency (P = 0.0388, OR = 6.1837). For patients with the rs10889677, a therapy with azathioprine was more frequently necessary(P = 0.0116, OR = 6.1707). Patients with rs10489629 SNP had a lower risk for weight loss(P = 0.0169, OR = 0.3394). Carriers of the heterozygous variant had a higher risk for an extended disease (P = 0.0284). The rs7517847 showed a protective character leading to mild bowel movements. Three SNPs demonstrated no statistically significant influence on any examined clinical features of UC.CONCLUSION We demonstrated susceptible or protective character of the investigated IL23 R SNPs on the phenotype of UC, confirming the genetic association. | Sarah Fischer Erzsébet Kovesdi Lili Magyari Veronika Csongei Kinga Hadzsiev Béla Melegh Péter Hegyi Patrícia Sarlós | 2017 | World Journal of Gastroenterology2017，23，3： | 3 |
| 2 | Apolipoprotein A5 T-1131 C variant confers risk for metabolic syndrome显示文摘 | Macisz A Kisfali P Horvatovich K Mohds M Marko L Csongei V | 2007 | Pathol Oncol Res2007，13，： | 1 |
| 3 | Susceptibility to ulcerative colitis in Hungarian patients determined by gene-gene interactions显示文摘AIM:To study the inflammatory bowel disease-5 locus(IBD5)and interleukin-23 receptor(IL23R)gene variants in UC patients and test for gene-gene interaction.METHODS:The study population(n=625)was comprised of 320 unrelated ulcerative colitis(UC)patients with Caucasian origin and 316 age-and gendermatched,healthy controls.Five variants in the IBD5 locus(IGR2198a_1 rs11739135,IGR2096a_1 rs12521868,IGR2230a_1 rs17622208,SLC22A4 rs1050152 and SLC22A5 rs2631367)and two of the IL23R gene(rs1004819,rs2201841)were analysed.PCR and restriction fragment length polymorphism methods were used for genotyping,the SLC22A4 rs1050152 genotypes were determined by direct sequencing.Interactions and specific genotype combinations of the seven variants were tested by binary logistic regression analysis.The IL23R genotypes were stratified by IBD5 genotypes for further interaction analyses.RESULTS:For the IL23R rs1004819 A allele we found significantly higher allele frequency(P=0.032)in UC patients compared to control subjects.The SNP rs1004819 showed significant association with UC risk for carriers(P=0.004,OR=1.606;95%CI:1.160-2.223)and the SNP rs2201841 for homozygotes(P=0.030,OR=1.983;95%CI:1.069-3.678).Individually none of the IBD5 markers conferred risk to UC development.There was no evidence for statistical interaction either between IBD5 loci and IL23R genes using logistic regression analysis.After genotype stratification,we could detect a positive association on the background of rs1004819 A allele for SLC22A4 T,SLC22A5 C,IGR2198a_1 C or IGR2096a_1 T allele,the highest OR was calculated in the presence of SLC22A4T allele(P=0.005,OR=2.015;95%CI:1.230-3.300).There was no association with UC for any combinations of rs1004819 and IGR2230a_1.The IL23R rs2201841homozygous genotype and IBD5 carrier status together did not confer susceptibility for UC.CONCLUSION:The present study has shown that UC susceptibility genes are likely to act in a complex interactive manner similar to CD. | Patricia Sarlos Dalma Varszegi Veronika Csongei Lili Magyari Luca Jaromi Lajos Nagy Bela Melegh | 2014 | World Journal of Gastroenterology2014，20，1： | 1 |
| 4 | Multiple suppression pathways of canonical Wnt signalling control thymic epithelial senescence显示文摘 | Zoltan Varecza Krisztian Kvell Gergely Talabér Gyorgy Miskei Veronika Csongei Domokos Bartis Graham Anderson Eric J. Jenkinson Judit E. Pongracz | 2011 | Mechanisms of Ageing and Development2011，，： | 1 |
| 5 | Earthworm leukocytes kill Hela, HEp-2, PC-12 and PA317 cells in vitro显示文摘 | Engelmann P Kiss J Csongei V | 2004 | J Biochem Biophys Methods2004，61，12： | 1 |
| 6 | Triglyceride levelmodifying functional variants of GALTN2 and MLXIPL inpatients with ischaemic stroke显示文摘 | Polgar N Jaromi L Csongei V | 2010 | Eur J Neurol2010，17，8： | 1 |
| 7 | Genetic variability and haplotype profile of MDR1 ( ABCBI ) in Roma and Hungarian population samples with a review of the literature显示文摘 | Sipeky C Csongei V Jaromi L | 2011 | Drug Metab Pharmacokinet2011，26，： | 1 |
| 8 | Investigation of JAK2,STAT3 andCCR6 polymorphisms and their gene-gene interactions in inflammatorybowel disease显示文摘 | Polgar N Csongei V Szabo M | 2012 | Int J Immunogenet2012，39，3： | 1 |
| 9 | Earthworm leukocytes kill HeLa,HEp-2,PC-12 and PA317 cells in vitro显示文摘 | Egelmann P Kiss J Csongei V | 2004 | J Biochem Biophys Methods2004，61，12： | 1 |
| 10 | Earthworm leukocytes kill HeLa,HEp-2,PC-12 and PA317 cells in vitro显示文摘 | ENGELMANN P KISS J CSONGEI V | 2004 | J Biochem Biophys Methods2004，61，12： | 1 |
| 11 | Down - regulation of canonical and up - regulation of non - canonical Wnt signalling in the carcinogenic process of squamous cell lung carcinoma显示文摘 | Bartis D Csongei V Weich A | 2013 | PLoS One2013，8，57： | 1 |
| 12 | Variants of the IL23 R gene are associated with ankylosing spondylitis but not with Sje;gren syn- drome in Hungarian population samples 显示文摘 | S6frdny E Pazdr B Csongei V | 2009 | Scand J Immunol2009，70，1： | 1 |
| 13 | Polymorphisms of the IL23R gene are associated with psoriasis but not with immunoglobulin A nephropathy in a Hungarian population显示文摘 | Safrany E Szell M Csongei V | 2011 | Inflammation2011，34，6： | 1 |
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