|
|
|
题名
|
作者
|
年代
|
出处
|
被引量
|
| 1 | Alcoholic liver disease:Utility of animal models显示文摘Alcoholic liver disease(ALD) is a major cause of acute and chronic liver injury. Extensive evidence has been accumulated on the pathological process of ALD during the past decades. However, effective treatment options for ALD are very limited due to the lack of suitable in vivo models that recapitulate the full spectrum of ALD. Experimental animal models of ALD, particularly rodents, have been used extensively to mimic human ALD. An ideal animal model should recapitulate all aspects of the ALD process, including significant steatosis, hepatic neutrophil infiltration, and liver injury. A better strategy against ALD depends on clear diagnostic biomarkers, accurate predictor(s) of its progression and new therapeutic approaches to modulate stop or even reverse the disease. Numerous models employing rodent animals have been established in the last decades to investigate the effects of acute and chronic alcohol exposure on the initiation and progression of ALD. Although significant progress has been made in gaining better knowledge on the mechanisms and pathology of ALD, many features of ALD are unknown, and require further investigation, ideally with improved animal models that more effectively mimic human ALD. Although differences in the degree and stages of alcoholic liver injury inevitably exist between animal models and human ALD, the acquisition and translational relevance will be greatly enhanced with the development of new and improved animal models of ALD. | Arantza Lamas-Paz Fengjie Hao Leonard J Nelson Maria Teresa Vázquez Santiago Canals Manuel Gómez del Moral Eduardo Martínez-Naves Yulia A Nevzorova Francisco Javier Cubero | 2018 | World Journal of Gastroenterology2018，24，45： | 26 |
| 2 | Differential effects of peroxisome proliferator-activated receptor activators on the mRNA levels of genes involved in lipid metabolism in primary human monocyte-derived macrophages显示文摘 | Cabrero A Cubero M Laverias G | 2003 | Metabolism2003，52，5： | 1 |
| 3 | Crystal structure of low magnesium-content alite: Application to Rietveld quantitative phase analysis 显示文摘 | DELATORRE A G DEVERA R N CUBEROS A J M | 2008 | Cem Concr Res2008，38，11： | 1 |
| 4 | Inventory and functional characterization of the HAK potassium transporters of rice显示文摘 | Banuelos M A Garciadeblas B Cubero B Navarro R N | 2002 | Plant Physiology2002，130，2： | 1 |
| 5 | C--H…O contacts in the Adenine…Uracil Watson Crick and Uracil…Uracil nucleic acid base pairs: Nonempirical ab Initio study with inclusion of electron correlation effects显示文摘 | Hobaz P Sponer A Cubero E | 2000 | J Phys Chem B2000，104，： | 1 |
| 6 | Inventory and functional characterization of the HAK potassium transporters of rice显示文摘 | Ba(n)uelos M A Garciadeblas B Cubero B | 2002 | Plant Physiology2002，130，： | 1 |
| 7 | Timing-dependent protection of hypertonic saline solution administration in experimental liver ischemia/reperfusion injury显示文摘 | Estela Regina Ramos Figueira Telesforo Bacchella Ana Maria Mendon?a Coelho Sandra Nassa Sampietre Nilza Aparecida Trindade Molan Regina Maria Cubero Leit?o Marcel Cerqueira Cesar Machado | 2010 | Surgery2010，，3： | 1 |
| 8 | Plasma lipoprotein(a) and severity of angiographic coronary artery disease显示文摘 | Batalla A Reguero JR Cubero GI | 1999 | J Am Coll Cardiol1999，33，： | 1 |
| 9 | Endoscopic treatment of persistent alveolar-pleural air leaks with a unidirectional endobronchial valve 显示文摘 | ROSELL A LOPEZ-LISBONA R CUBERO N | 2011 | Arch Bronconeumol2011，47，7： | 1 |
| 10 | Characterization of metabotropic glutamate receptors coupled to a pertussis toxin sensitive G-protein in bovine brain coated vesicles显示文摘 | Martin M Sanz JM and Cubero A | 1993 | FEBS lett1993，316，2： | 1 |
| 11 | Ameva:an autonomous discretization algorithm 显示文摘 | GONZALEZ A L CUBEROS F J VELASCO F | 2008 | Expert Systems with Applications2008，36，3： | 1 |
| 12 | POTMiner: mining ordered, unordered, and partially-ordered trees显示文摘 | Aída Jiménez Fernando Berzal Juan-Carlos Cubero | 2010 | Knowledge and Information Systems2010，，2： | 1 |
| 13 | Differential effects of peroxisome proliferator-activa- ted receptor activators on the mRNA levels of genes involved in lipid metabolism in primary human mono- eyte-derived maerophages显示文摘 | CABRERO A CUBERO M LAVERIAS G | 2003 | Metabolism2003，52，： | 1 |
| 14 | Identifying rose cukivars using random amplified polymorphic DNA markers显示文摘 | Torres A M Mill An T Cubero J I | 1993 | HortScience1993，28，4： | 1 |
| 15 | DNA extraction and PCR amplification method suitable for fresh,herbarium stored,lichenized and other fungi显示文摘 | Cubero O F Crepo A Fatehi J | 1999 | Plant Systematics and Evolution1999，216，： | 1 |
| 16 | Crystal structure of low magnesium-content alite:application to rietveld quantitative phase analysis显示文摘 | Delatorre A G Devera R N Cuberos A J M | 2008 | Cement and Concrete Research2008，38，11： | 1 |
| 17 | Inventory and functional characterization of the HAK potassium transporters of rice 显示文摘 | BANUELOS M A Garciadeblas B Cubero B | 2002 | Plant Physiol2002，130，： | 1 |
| 18 | Identifying rose eultivars using random amplified polymorphic DNA markers 显示文摘 | TIRRES A M MILLAN T CUBERO J I | 1993 | HortScience1993，28，4： | 1 |
| 19 | Timing-dependent protection of hypertonic saline solution administration in experimental liver ischemia/reperfusion injury显示文摘 | Estela Regina Ramos Figueira Telesforo Bacchella Ana Maria Mendon?a Coelho Sandra Nassa Sampietre Nilza Aparecida Trindade Molan Regina Maria Cubero Leit?o Marcel Cerqueira Cesar Machado | 2010 | Surgery2010，，3： | 1 |
| 20 | Mutants of the Arabidopsis thaliana Cation/H + Antiporter AtNHX1 conferring increased salt tolerance in Yeast:the endosome/prevacuolar compartment is a target for salt toxicity显示文摘 | HERN(A)NDEZ A JIANG X Y CUBERO B | 2009 | J Biol Chem2009，284，14： | 1 |
您所在的机构暂未开通此部分的功能，请联系管理员