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| 1 | Mn-containing bioceramics inhibit osteoclastogenesis and promote osteoporotic bone regeneration via scavenging ROS显示文摘Osteoporosis is caused by an osteoclast activation mechanism.People suffering from osteoporosis are prone to bone defects.Increasing evidence indicates that scavenging reactive oxygen species(ROS)can inhibit receptor activator of nuclear factorκB ligand(RANKL)-induced osteoclastogenesis and suppress ovariectomy-induced osteoporosis.It is critical to develop biomaterials with antioxidant properties to modulate osteoclast activity for treating osteoporotic bone defects.Previous studies have shown that manganese(Mn)can improve bone regeneration,and Mn supplementation may treat osteoporosis.However,the effect of Mn on osteoclasts and the role of Mn in osteoporotic bone defects remain unclear.In present research,a model bioceramic,Mn-containedβ-tricalcium phosphate(Mn-TCP)was prepared by introducing Mn intoβ-TCP.The introduction of Mn intoβ-TCP significantly improved the scavenging of oxygen radicals and nitrogen radicals,demonstrating that Mn-TCP bioceramics might have antioxidant properties.The in vitro and in vivo findings revealed that Mn^(2+)ions released from Mn-TCP bioceramics could distinctly inhibit the formation and function of osteoclasts,promote the differentiation of osteoblasts,and accelerate bone regeneration under osteoporotic conditions in vivo.Mechanistically,Mn-TCP bioceramics inhibited osteoclastogenesis and promoted the regeneration of osteoporotic bone defects by scavenging ROS via Nrf2 activation.These results suggest that Mn-containing bioceramics with osteoconductivity,ROS scavenging and bone resorption inhibition abilities may be an ideal biomaterial for the treatment of osteoporotic bone defect. | Jianmei Li Cuijun Deng Wanyuan Liang Fei Kang Yun Bai Bing Ma Chengtie Wu Shiwu Dong | 2021 | Bioactive Materials2021，6，11： | 7 |
| 2 | An atypical component of RNA-directed DNA methylation machinery has both DNA methylation-dependent and -independent roles in locus-specific transcriptional gene silencing显示文摘指导 RNA 的 DNA methylation (RdDM ) 是在植物的一条重要 de novo DNA methylation 小径。RdDM 调停许多内长的 genomic loci,其大多数是联系的 transposon 的 transcriptional silencing。一幅前面的遗传屏幕在 Arabidopsis 为 RdDM 作为一个新部件识别了 DTF1 (DNA 有约束力的抄写因素 1 ) 。在 DTF1 的 Loss-of-function 变化释放 RdDM 目标 loci 的 transcriptional silencing 并且减少 24-nt 的累积从一些目标的小介入 RNA (siRNAs ) 。在 dtf1 异种植物,有趣地,在 solo-LTR 的 transcriptional 基因 silencing 的版本被减少的 siRNA 累积然而并非由减少的 DNA methylation 伴随。这些结果建议 DTF1 是 RdDM 的一个不正常的部件并且在 transcriptional 基因 silencing 有 methylation 依赖的两 DNA 和独立角色。我们建议除 DNA methylation 以外, siRNAs 可以引起某另外的 uncharacterized 导致 transcriptional 基因 silencing 的 epigenetic 修正。 | Jun Liu Ge Bai Cuijun Zhang Wei Chen Jinxing Zhou Suwei Zhang Qing Chen Xin Deng Xin-Jian He Jian-Kang Zhu | 2011 | Cell Research2011，21，12： | 6 |
| 3 | Survival and Metabolic Responses to Freezing Temperature in the Northeast For- est Frog Rana dybowskii 显示文摘 | Xiao Xianghong Zheng Dong Yang Cuijun | 2008 | Asiatic Herpetological Research2008，11，： | 1 |
| 4 | Fabrication of Photo-crosslinked Chitosan- Gelatin Scaffold in Sodium Alginate Hydrogel for Chondrocyte Culture显示文摘 | Feng Liu Ali Goodarzi Haifeng Wang Joanna Stasiak Jianbo Sun Yu Zhou Peng Zhao Cuijun Deng Hongzhen Xu Xing Tang Hailong He Chao Lin Jiansheng Su | 2014 | Bio-Medical Materials and Engineering2014，，1： | 1 |
| 5 | INVARIANT MEASURES AND UNIFORM POSITIVE ENTROPY PROPERTY FOR INVERSE LIMITS显示文摘In this paper, the interconnection of som e ergodic properties betw een a continuous selfm ap and its inverse lim itis studied. Ithas been proved that(1) theirinvariantBorelproba- bility m easures are identicalup to hom eom orphism and (2) they preserve uniform positive en- tropy property sim ultaneously. As applications, it is also proved that the upper sem i-continu- ous properties of their entropy m aps are restricted each other, and the entropy m ap of the asym ptotically h-expansivecontinuous m ap isuppersem i-continuous, atthe sam e tim e acontin- uous m ap having u.p.e. is topologicalweak-m ixing. | He Lianfa Liu Cuijun Dept. of Math., HebeiNorm alUniv., Shijiazhuang 050016. | 1999 | Applied Mathematics(A Journal of Chinese Universities)1999，14，3： | 1 |
| 6 | Surviva/and metabolic responses to freezing temperature in the northeast forest frog Rana dybowskii 显示文摘 | Xianghong X Dong Z Cuijun Y | 2008 | Asiatic Herpetological Research2008，11，： | 1 |
| 7 | Identification of natural allelic variation in TTL1 controlling thermotolerance and grain size by a rice super pan-genome∞显示文摘Continuously increasing global temperatures present great challenges to food security.Grain size,one of the critical components determining grain yield in rice(Oryza sativa L.),is a prime target for genetic breeding.Thus,there is an immediate need for genetic improvement in rice to maintain grain yield under heat stress.However,quantitative trait loci(QTLs)endowing heat stress tolerance and grain size in rice are extremely rare.Here,we identified a novel negative regulator with pleiotropic effects,Thermo‐Tolerance and grain Length 1(TTL1),from the super pan‐genomic and transcriptomic data.Loss‐of‐function mutations in TTL1 enhanced heat tolerance,and caused an increase in grain size by coordinating cell expansion and proliferation.TTL1 was shown to function as a transcriptional regulator and localized to the nucleus and cell membrane.Furthermore,haplotype analysis showed that hapL and hapS of TTL1 were obviously correlated with variations of thermotolerance and grain size in a core collection of cultivars.Genome evolution analysis of available rice germplasms suggested that TTL1 was selected during domestication of the indica and japonica rice subspecies,but still had much breeding potential for increasing grain length and thermotolerance.These findings provide insights into TTL1 as a novel potential target for the development of high‐yield and thermotolerant rice varieties. | Yarong Lin Yiwang Zhu Yuchao Cui Hongge Qian Qiaoling Yuan Rui Chen Yan Lin Jianmin Chen Xishi Zhou Chuanlin Shi Huiying He Taijiao Hu Chenbo Gu Xiaoman Yu Xiying Zhu Yuexing Wang Qian Qian Cuijun Zhang Feng Wang Lianguang Shang | 2023 | Journal of Integrative Plant Biology2023，65，12： | 0 |
| 8 | Taxonomic review of Chinese ant genus Probolomyrmex(Hymenoptera:Formicidae)显示文摘Four species of the ant genus Probolomyrmex in the subfamily Proceratiinae are recognized in China,namely P.dammermani,P.longiscapus,P.longinodus and P.vieti.Two species,P.dammermani and P.vieti are recorded in China for the first time.A key to the known Chinse species of the genus based on worker caste is presented. | Cuijun Liang Zhilin Chen | 2022 | Zoological Systematics2022，47，2： | 0 |
| 9 | Large-scale identification of expression quantitative trait loci in Arabidopsis reveals novel candidate regulators of immune responses and other processes显示文摘The extensive phenotypic diversity within natural populations of Arabidopsis is associated with differences in gene expression.Transcript levels can be considered as in-heritable quantitative traits,and used to map expression quantitative trait loci(eQTL)in genome-wide association studies(GWASs).In order to identify putative genetic de-terminants for variations in gene expression,we used pub-licly available genomic and transcript variation data from 665 Arabidopsis accessions and applied the single nucleotide polymorphism-set(Sequence)Kernel Association Test(SKAT)method for the identification of eQTL.Moreover,we used the penalized orthogonal-components regression(POCRE)method to increase the power of statistical tests.Then,gene annotations were used as test units to identify genes that are associated with natural variations in transcript accumulation,which correspond to candidate regulators,some of which may have a broad impact on gene ex-pression.Besides increasing the chances to identify real as-sociations,the analysis using POCRE and SKAT significantly reduced the computational cost required to analyze large datasets.As a proof of concept,we used this approach to identify eQTL that represent novel candidate regulators of immune responses.The versatility of this approach allows its application to any process that is subjected to natural var-iation among Arabidopsis accessions. | Xingang Wang Min Ren Danni Liu Dabao Zhang Cuijun Zhang Zhaobo Lang Alberto PMacho Min Zhang Jian-Kang Zhu | 2020 | Journal of Integrative Plant Biology2020，62，10： | 0 |
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