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| 1 | Allogenic banking of dental pulp stem cells for innovative therapeutics显示文摘Medical research in regenerative medicine and cellbased therapy has brought encouraging perspectives for the use of stem cells in clinical trials. Multiple types of stem cells, from progenitors to pluripotent stem cells, have been investigated. Among these, dental pulp stem cells(DPSCs) are mesenchymal multipotent cells coming from the dental pulp, which is the soft tissue within teeth. They represent an interesting adult stem cell source because they are recovered in large amount in dental pulps with non-invasive techniques compared to other adult stem cell sources. DPSCs can be obtained from discarded teeth, especially wisdom teeth extracted for orthodontic reasons. To shift from promising preclinical results to therapeutic applications to human, DPSCs must be prepared in clinical grade lots and transformed into advanced therapy medicinal products(ATMP). As the production of patient-specific stem cells is costly and time-consuming, allogenic biobanking of clinical grade human leukocyte antigen(HLA)-typed DPSC lines provides efficient innovative therapeutic products. DPSC biobanks represent industrial and therapeutic innovations by using discarded biological tissues(dental pulps) as a source of mesenchymal stem cells to produce and store, in good manufacturing practice(GMP) conditions, DPSC therapeutic batches. In this review, we discuss about the challenges to transfer biological samples from a donor to HLA-typed DPSC therapeutic lots, following regulations, GMP guidelines and ethical principles. We also present some clinical applications, for which there is no efficient therapeutics so far, but that DPSCs-based ATMP could potentially treat. | Pierre-Yves Collart-Dutilleul Franck Chaubron John De Vos Frederic J Cuisinier | 2015 | World Journal of Stem Cells2015，7，7： | 7 |
| 2 | Quantification of the effects of nitrates, phosphates and chlorides on soil stabilization with lime and cement显示文摘 | Olivier Cuisinier Tangi Le Borgne Dimitri Deneele Farimah Masrouri | 2010 | Engineering Geology2010，，3： | 2 |
| 3 | Comparison of the structure of polyelectrolyte multilayer films exhibiting a linear and an exponential growth regime: an in situ atomic force microscopy study 显示文摘 | Lavalle P Gergely C Cuisinier F J G | 2002 | Macromolecules2002，35，： | 1 |
| 4 | High resolution electron microscopy study of crystal growth mechanisms in chicken bone composites显示文摘 | Cuisinier F Steuer P Brisson A | 1995 | J Cryst Growth1995，156，： | 1 |
| 5 | Surface-enhanced redox chemistry of polysulphides on a metallic and polar host for lithium-sulphur batteries显示文摘 | Pang Q Kundu D Cuisinier M | 2014 | Nature Communications2014，5，： | 1 |
| 6 | Quantification of the effects of nitrates, phosphates and chlorides on soil stabilization with lime and cement显示文摘 | Olivier Cuisinier Tangi Le Borgne Dimitri Deneele | 2011 | Eng Geol2011，117，： | 1 |
| 7 | Sensory supplementation through tongue electrotactile stimulation to preserve head stabilization in space in the absence of vision显示文摘 | VUILLERME N CUISINIER R | 2008 | Investigative Ophthalmology & Visual Science2008，50，1： | 1 |
| 8 | A prospective study of risk factors predicting grief intensity following pregnancy loss显示文摘 | Janssen HJ Cuisinier MC de Graauw KP | | 0，，01： | 1 |
| 9 | Miscarriage and still birth:Time since the loss grief intensity and satisfaction with cares显示文摘 | Cuisinier MC Kuijpers JC Hoogduin CA | | 0，，03： | 1 |
| 10 | Secnidazole concentrations in plasma and crevicular fluid after a single oral dose显示文摘 | Tenebaum H Cuisinier FJG Le Liboux A | 1993 | J Clin Periodontol1993，20，： | 1 |
| 11 | Controlled Prospective Study of the Mental Health of Women Following Pregnancy Loss 显示文摘 | Janssen Hettie J E M Cuisinier Marian C J Hoogduin | 1996 | Am J Psychiatry1996，153，： | 1 |
| 12 | Soil treatment with organic non-traditional additives for the improvement of earthworks显示文摘 | BLANCK C~ CUISINIER O MASROURI F | 2013 | Acta Geotechnica2013，8，1： | 1 |
| 13 | Histological analysis of the Ankylos peri-implant soft tissues in a dog model显示文摘 | Tenenbaum H Schaaf JF Cuisinier FJ | 2003 | Implant Dent2003，12，3： | 1 |
| 14 | Stepwise surface encoding for high-throughput assembly of nanoclus ters显示文摘 | Maye M M Nykypanchuk D Cuisinier M | 2009 | Nature Mater2009，8，： | 1 |
| 15 | Quantification of the effects of nitrates,phosphates and chlorides on soil stabilization with lime and cement显示文摘 | Cuisinier O Borgne T L Deneele D | 2011 | Geology Engineering2011，117，34： | 1 |
| 16 | Dental stem cell-conditioned medium for tissue regeneration: Optimization of production and storage显示文摘BACKGROUND Mesenchymal stem cells(MSC)effects on tissue regeneration are mainly mediated by their secreted substances(secretome),inducing their paracrine activity.This Conditioned medium(CM),including soluble factors(proteins,nucleic acids,lipids)and extracellular vesicles is emerging as a potential alternative to cell therapy.However,the manufacturing of CM suffers from variable procedures and protocols leading to varying results between studies.Besides,there is no welldefined optimized procedure targeting specific applications in regenerative medicine.AIM To focus on conditioned medium produced from dental MSC(DMSC-CM),we reviewed the current parameters and manufacturing protocols,in order to propose a standardization and optimization of these manufacturing procedures.METHODS We have selected all publications investigating the effects of dental MSC secretome in in vitro and in vivo models of tissue regeneration,in accordance with the PRISMA guidelines.RESULTS A total of 351 results were identified.And based on the inclusion criteria described above,118 unique articles were included in the systematic review.DMSC-CM production was considered at three stages:before CM recovery(cell sources for CM),during CM production(culture conditions)and after production(CM treatment).CONCLUSION No clear consensus could be recovered as evidence-based methods,but we were able to describe the most commonly used protocols:donors under 30 years of age,dental pulp stem cells and exfoliated deciduous tooth stem cells with cell passage between 1 and 5,at a confluence of 70%to 80%.CM were often collected during 48 h,and stored at-80°C.It is important to point out that the preconditioning environment had a significant impact on DMSCCM content and efficiency. | Batoul Chouaib Frédéric Cuisinier Pierre-Yves Collart-Dutilleul | 2022 | World Journal of Stem Cells2022，14，4： | 1 |
| 17 | Quantification of the effects of nitrates, phosphates and chlorides on soil stabilization with lime and cement显示文摘 | Olivier Cuisinier Tangi Le Borgne Dimitri Deneele | 2011 | Eng Geol2011，117，： | 1 |
| 18 | Quantification of the effects of nitrates, phosphates and chlorides on soil stabilization with lime and cement显示文摘 | CUISINIER O LE BORGNE T DENEELE D | 2011 | Engineering Geology2011，117，3： | 1 |
| 19 | Changes in plasma and urinary taurine and amino acids in runners immediately and 24h after a marathon 显示文摘 | Cuisinier C Ward R Francaux M | 2001 | Amino Acids2001，20，1： | 1 |
| 20 | Changes in plasma taurine levels after different endurance events显示文摘 | Ward RJ Francaux M Cuisinier C | 1999 | Amino Acids1999，16，1： | 1 |
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