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| 1 | Clinical significance of NOD2/CARD15 and Toll-like receptor 4 gene single nucleotide polymorphisms in inflammatory bowel disease显示文摘AIM: To evaluate the role of genetic factors in the pathogenesis of Crohn's disease (CD) and ulcerative colitis (UC), we investigated the single nucleotide poly- morphisms (SNPs) of NOD2/CARD15 (R702W, G908R and L1007fi nsC), and Toll-like receptor 4 (TLR4) genes (D299G and T399I) in a selected inflammatory bowel disease (IBD) population coming from Southern Italy. METHODS: Allele and genotype frequencies of NOD2/ CARD15 (R702W, G908R and L1007finsC) and TLR4 (D299G and T399I) SNPs were examined in 133 CD pa-tients, in 45 UC patients, and in 103 healthy controls. A genotype-phenotype correlation was performed. RESULTS: NOD2/CARD15 R702W mutation was sig-nificantly more frequent in CD (9.8%) than in controls (2.4%, P = 0.001) and in UC (2.3%, P = 0.03). No sig-nificant difference was found between UC patients and control group (P > 0.05). In CD and UC patients, no signifi cant association with G908R variant was found. L1007f insC SNP showed an association with CD (9.8%) compared with controls (2.9%, P = 0.002) and UC patients (2.3%, P = 0.01). Moreover, in CD patients, G908R and L1007finsC mutations were significantly associated with different phenotypes compared to CD wild-type patients. No association of IBD with the TLR4 SNPs was found in either cohort (allele frequencies: D299G-controls 3.9%, CD 3.7%, UC 3.4%, P > 0.05; T399I-controls 2.9%, CD 3.0%, UC 3.4%, P > 0.05). CONCLUSION: These findings confirm that, in our IBD patients selected from Southern Italy, the NOD2/ CARD15, but not TLR4 SNPs, are associated with in-creased risk of CD. | Luciana Rigoli Claudio Romano Rosario Alberto Caruso Maria A Lo Presti Chiara Di Bella Vincenzo Procopio Giuseppina Lo Giudice Maria Amorini Giuseppe Costantino Maria D Sergi Caterina Cuppari Giovanna Elisa Calabrò Romina Gallizzi Carmelo Damiano Salpietro Walter Fries | 2008 | World Journal of Gastroenterology2008，14，28： | 8 |
| 2 | Role of the diet as a link between oxidative stress and liver diseases显示文摘Oxidative stress is caused by an imbalance between the production of reactive oxygen(free radicals) and the body's ability(antioxidant capacity) to readily detoxify the reactive intermediates or easily repair the resulting damage. An adequate diet, characterized by daily intake of foods associated with improvementsin the total antioxidant capacity of individuals and reduced incidence of diseases related to oxidation, can modulate the degree of oxidative stress. In fact, dietderived micronutrients may be direct antioxidants, or are components of antioxidant enzymes, leading to improvement of some indicators of hepatic function. However, although their increased dietary intake might be beneficial, literature data are still controversial. This review summarizes what is known about the effects of diet nutrients on oxidative stress, inflammation and liver function. Moreover, we have analyzed:(1) the main nutritional components involved in the production and/or removal of free radicals; and(2) the role of free radicals in the pathogenesis of several hepatic diseases and related comorbidities. | Teresa Arrigo Salvatore Leonardi Caterina Cuppari Sara Manti Angela Lanzafame Gabriella D'Angelo Eloisa Gitto Lucia Marseglia Carmelo Salpietro | 2015 | World Journal of Gastroenterology2015，21，2： | 2 |
| 3 | Effect of hard second phase on cavitation erosion of Fe-Cr-Ni-C alloys显示文摘 | Cuppari V Souza R M | 2005 | Wear2005，258，： | 1 |
| 4 | Serum interleukin 17, interleukin 23, and interleukin 10 values in children with atopic eczema/dermatitis syndrome(AEDS): association with clinical severity and phenotype显示文摘 | Leonardi S Cuppari C Manti S | 2015 | Allergy Asthma Proc2015，36，1： | 1 |
| 5 | Successful use of etanercept in a patient with pyoderma gangrenosum complicating rheumatoid arthritis显示文摘 | Disla E Quayum B Cuppari GG | 2004 | J Clin Rheumatol2004，10，1： | 1 |
| 6 | In- creased resting energy expenditure in hemodialysis pa- tients with severe hyperparathyroidism显示文摘 | Cuppari L de Carvalho AB Avesani CM | 2004 | J Am Soc Nephrol2004，15，： | 1 |
| 7 | High sodi- um chloride intake is associated with low bone density in calcium stone-forming patients显示文摘 | Martini LA Cuppari L Colugnati FA | 2000 | Clin Nephrol2000，54，2： | 1 |
| 8 | Effect of hard second phase on cavitation erosion of Fe-Cr-Ni-C alloys显示文摘 | Div M G Cuppari Souza R M | | Wear0，2581，： | 1 |
| 9 | High prevalence of low bone mineral density in pre-dialysis chronic kidey disease patients: bone histomorphometric analysis 显示文摘 | Lobao R Carvalho AB Cuppari L | 2004 | Clin Nephrol2004，62，6： | 1 |
| 10 | Resting energy expenditure in pre-dialysis diabetic patients 显示文摘 | Avesani CM Cuppari L Silva AC | 2001 | Nephrol Dial Transplant2001，16，3： | 1 |
| 11 | Nutritional condition in chronic renal failure patients treated by hemodialysis in Amazonas 显示文摘 | Valenzuela RG Giffoni AG Cuppari L | 2003 | Rev Assoc Med Bras2003，49，1： | 1 |
| 12 | Nutritional status of hemodialysis patients with secondary hyperparathyroidism 显示文摘 | Rezende LT Cuppari L Carvalho AB | 2000 | Brazi J Medl Biol Res2000，33，11： | 1 |
| 13 | Association of Changes in Bone Remodeling and Coronary Calcification in Hemodialysis Patients: A Prospective Study显示文摘 | Daniela Veit Barreto Fellype de Carvalho Barreto Aluízio Barbosa de Carvalho Lilian Cuppari Sérgio Antonio Draibe Maria Aparecida Dalboni Rosa Maria Affonso Moyses Kátia Rodrigues Neves Vanda Jorgetti Márcio Miname Raul D. Santos Maria Eugênia F. Canziani | 2008 | American Journal of Kidney Diseases2008，，6： | 1 |
| 14 | Risk factors for hypovitaminosis D in nondialyzed chronic kidney disease patients显示文摘 | Figuiredo-Dias V Cuppari L Garcia-Lopes MG | 2012 | J Ren Nutr2012，22，1： | 1 |
| 15 | Effect of hard second phase on cavitation erosion of Fe-Cr-Ni-C alloys显示文摘 | DiV M G Cuppari Souza R M Sinatora A | 2008 | Wear2008，，258： | 1 |
| 16 | Etiology of the protein-energy wasting syndrome in chronic kidney disease:a consensus statement from the International Society of Renal Nutrition and Metabolism (ISRNM)显示文摘 | Carrero JJ Stenvinkel P Cuppari L | | 0，，02： | 1 |
| 17 | Nutritional condition irl chronic renal failure Patiens treated by hemordialysis in Amazonas 显示文摘 | Valenzuela Ra ailfoni AG Cuppari I et aI | 2003 | Rev Assoc Med Bed Bras2003，49，1： | 1 |
| 18 | Risk fac-tors for hypovitaminosis D in nondialyzed chronic kidney diseasepatients显示文摘 | Figuiredo-Dias V Cuppari L Garcia-Lopes MG | 2012 | J Ren Nutr2012，22，1： | 1 |
| 19 | High prevalence of low bone mineral density in pre - dialysis chronic kidney disease patients: bone histomorphometfic analysis 显示文摘 | Lobao R Carvalho AB Cuppari L | 2004 | Clin Nephrol2004，62，6： | 1 |
| 20 | Nutrition and Metabolism in Kidney Disease显示文摘 | Pupimm LB Cuppari Li Ikizler TA | | 0，，： | 1 |
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