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| 1 | 从附睾到卵子:CRISP蛋白在哺乳动物受精过程中的作用显示文摘哺乳动物的受精过程涉及精卵结合的很多步骤,是一个非常复杂的过程,其分了机制亟待阐明。此篇综述主要论述了CRISP(富含半胱氨酸的分泌蛋白)作为模型分子在哺乳动物受精过程中的价值。大量的体外实验和基因敲出模型研究显示,附睾内的CRISP1以两种不同的亲和力结合于精子表面,参与精子获能、精子-透明带结合、精卵融合的调控。这些研究成果可以延伸至人类。我们住研究中发现,人类具有与啮齿类同源的CRISP(hCRISP1),同样参与受精过样。CRISP家族的其他成员(睾丸内CRISP2、附挈内CRISP3—4、射精时的CRISP3)也参与了精卵结合的过程,提示同源分子间的相互协同有助于受精的成功。另外,我们的研究显示,CRISP蛋白伴随精子穿越男性及女性生殖管道的全过程。我们推测CRISP不仅参与了受精过程,而且可能成为不育和避孕研究的新靶点。 | Vanina G Da Ros Mariana Weigel Munoz Maria A Battistone Nicolas G Brukman Guillermo Carvajal Ludmila Curci Matlas D Gomez-Elias Debora J Cohen Patricia S Cuasnicu | 2015 | Asian Journal of Andrology2015，17，5： | 5 |
| 2 | Ultrasound in screening of endometrial carcinoma in asymptomatic postmenopausal women显示文摘 | Curcie A Durdevic S Mladenovic-Segedi L | 2009 | Med Pregl2009，62，56： | 1 |
| 3 | IL-2, TNF-alpha, and leptin:local versus systemic concentration in NSCLC patients 显示文摘 | Carpagnano GE Spanevelio A Curci C | 2007 | Oncol Res2007，16，： | 1 |
| 4 | Preoperative treatment with doxycycline reduces aortic wall expression and activation of matrix metalloproteinases in patients with abdominal aortic aneurysms 显示文摘 | CURCI J A MAOD BOHNER D G | 2000 | J Vasc Surg2000，31，2： | 1 |
| 5 | Soil microbial dynamics and genetic diversity in soil under monoculture wheat grown in different long-term management systems显示文摘 | CRECCHIO C CURCI M PELLEGRINO A | 2007 | Soil Biology and Biochemistry2007，39，： | 1 |
| 6 | IL-2, TNF-alpha, and leptin: local versus systemic concentrations in NSCLC patients显示文摘 | Carpagnano GE Spanevello A Curci C | 2007 | Oncol Res2007，16，8： | 1 |
| 7 | IL-2,TNF-alpha,and leptin:local versus systemic concentrations in NSCLC patients显示文摘 | Carpagnano GE Spanevello A Curci C | 2007 | Oncol Res2007，16，8： | 1 |
| 8 | Juvenile criminality: general str- ain theory and the reactive-proactive aggression trait 显示文摘 | Greco R Curci A Grattagliano I | 2009 | Riv Psichiatr2009，44，5： | 1 |
| 9 | Soil microbial dynamics and genetic diversity in soil under monoculture wheat grown in different long-term management systems显示文摘 | Crecchio C Curci M Pellegrino A | 2007 | Soil Biology and Biochemistry2007，39，6： | 1 |
| 10 | Microbial 16S gene-based composition of a sorghum cropped rhizosphere soil under different fertilization managements显示文摘 | Lavecchia A Curci M Jangid K | 2015 | Biol Fertil Soils2015，51，： | 1 |
| 11 | IL-2, TNF-alpha, and leptin: local versus systemic concentrations in NSCLC patients 显示文摘 | Carpagnano GE Spanevello A Curci C | 2007 | Oncol Res2007，16，8： | 1 |
| 12 | Biomimetic finger control by filtering of distributed forelimb pressures 显示文摘 | David J Curcie James A William | 2001 | IEEE Transaction on Neural Systems and Rehabilitation engineering2001，9，1： | 1 |
| 13 | Elastic fiber depletion in the supporting ligamentsof the gastroesophageal junction : a structural basis forthe development of hiatal hernia 显示文摘 | CURCI J A MELMAN L M THOMPSON R W etal | 2008 | J Am CollSurg2008，207，2： | 1 |
| 14 | Preoperative treatment with doxycycline reduces aortic wall expression and activation of matrix metalloproteinases in patient with abdominal aortic aneurysms显示文摘 | Curci J A Mao D Bohner D G | 2000 | J Vasc Surg2000，31，2： | 1 |
| 15 | Transvaginal sonography of the postmenopausal endometrium显示文摘 | Curcis A Segedi D Belopavlvovic Z | 2000 | Med Pregl2000，53，1： | 1 |
| 16 | Soil microbial dynamics and genetic diversity in soil under monoculture wheat grown in different long-term management systems显示文摘 | Crecchio C?Curci M Pellegrino A et aL | 2007 | Soil Biology and Biochemistry2007，39，6： | 1 |
| 17 | IL-2,TNF-α,and leptin:local versus systemic concentrations in NSCLC patients显示文摘 | Carpagnano G E Spanevello A Curci C | 2006 | Oncology Research Featuring Preclinical and Clinical Cancer Therapeutics2006，16，8： | 1 |
| 18 | Juvenile criminality: general strain theory and the reactive-proactive aggression trait 显示文摘 | Greco R Curci A Grattagliano I | 2010 | Riv Psichiatr2010，44，5： | 1 |
| 19 | Review of the |iterature显示文摘 | Rizzi R Curci P Delia M Rinaldi E Chiefa A Specchia G et aL Spontaneous remission of 'methotrexate-associated lymphoproliferative disorders' after discontinuation of immunosuppressive treatment for autoimmune disease | 2009 | Med Oncol2009，26，1： | 1 |
| 20 | IL-2,TNF-alpha,and leptin:local versus systemic concentrations in NSCLC patients显示文摘 | Carpagnano GE Spanevello A Curci C | 2007 | Oncol Res2007，16，8： | 1 |
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