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| 1 | Correlation of N-myc downstream-regulated gene 1 expression with clinical outcomes of colorectal cancer patients of different race/ethnicity显示文摘AIM: To evaluate the role of N-myc downstream-regulated gene 1 (NDRG1) expression in prognosis and survival of colorectal cancer patients with different ethnic backgrounds. METHODS: Because NDRG1 is a downstream target of p53 and hypoxia inducible factor-1α (HIF-1α),we examined NDRG1 expression together with p53 and HIF-1α by immunohistochemistry. A total of 157 colorectal cancer specimens including 80 from Japanese patients and 77 from US patients were examined. The correlation between protein expression with clinicopathological features and survival after surgery was analyzed.in colorectal tumor compared with normal epithelium in both Japanese and US patient groups. Expression of NDRG1 protein was significantly correlated with lymphatic invasion,venous invasion,depth of invasion,histopathological type,and Dukes' stage in Japanese colorectal cancer patients. NDRG1 expression was correlated to histopathological type,Dukes' stage and HIF-1α expression in US-Caucasian patients but not in US-African American patients. Interestingly,Kaplan-Meier survival analysis demonstrated that NDRG1 expression correlated significantly with poorer survival in US-African American patients but not in other patient groups. However,in p53-positive US cases,NDRG1 positivity correlated significantly with better survival. In addition,NDRG1 expression also correlated significantly with improved survival in US patients with stages Ⅲ and Ⅳ tumors without chemotherapy. In Japanese patients with stages Ⅱ and Ⅲ tumors,strong NDRG1 staining in p53-positive tumors correlated significantly with improved survival but negatively in patients without chemotherapy. CONCLUSION: NDRG1 expression was correlated with various clinicopathological features and clinical outcomes in colorectal cancer depending on the race/ethnicity of the patients. NDRG1 may serve as a biological basis for the disparity of clinical outcomes of colorectal cancer patients with different ethnic backgrounds. | Minori Koshiji Kensuke Kumamoto Keiichirou Morimura Yasufumi Utsumi Michiko Aizawa Masami Hoshino Shinji Ohki Seiichi Takenoshita Max Costa Thérèse Commes David Piquemal Curtis C Harris Kam-Meng Tchou-Wong | 2007 | World Journal of Gastroenterology2007，13，20： | 25 |
| 2 | Zebrafish : bridging the gap between development and disease 显示文摘 | Dodd A Curtis PM Williams L C | 2000 | Hum Mol Genet2000，9，： | 1 |
| 3 | Choline acetyltransferase and calcitonin gene-related peptide immunoreactivity in motoneurons after different types of nerve injury显示文摘 | Borke RC Curtis M Ginsberg C | 1993 | J Neurocytol1993，22，3： | 1 |
| 4 | Development and testing of a rapid appraisal wetland condition index in southeastern Australia显示文摘 | SPENCER C ROBERTSON A I CURTIS A | 1998 | Environmental Management1998，54，2： | 1 |
| 5 | A method for analyzing plant architecture as it relates to fruit qualibty using three-dimensional computer graphics显示文摘 | Smith G S Curtis J P Edwards C M | 1992 | Annals of Botany1992，70，： | 1 |
| 6 | Attitude Changes toward Foreign Products 显示文摘 | Curtis C Reierson | 1967 | Journal of Marketing Research1967，，4： | 1 |
| 7 | Media and memo- ry: the efficacy of video and print materials for promoting pa- tient education about asthma显示文摘 | Wilson E A Park D C Curtis L M | 2010 | Patient Educ Couns2010，80，3： | 1 |
| 8 | 2011 ACCF/AHA/HRS focused update on the management of patientswith atrial fibrillation (Updating the 2006 Guideline) :areport of the American College of Cardiology Foundation/American Heart Association Task Force on PracticeGuidelines显示文摘 | Wann L S Curtis A B January C T | 2011 | J Am Coll Cardiol2011，57，2： | 1 |
| 9 | 查看详情显示文摘 | Mayer J M Curtis C J Bercaw J E | | 0，，： | 1 |
| 10 | Chronic illness as a result of low-level exposure to synthetic pyrethroid insecticides:A review of the debate显示文摘 | Kolaczinski J H Curtis C F | 2004 | Food and Chemical Toxicology2004，42，5： | 1 |
| 11 | A practical vision for optical transport networking 显示文摘 | Alferness Rod C Bonenfant Paul A Newton Curtis J | 1999 | Bell Labs Technical Journal1999，4，1： | 1 |
| 12 | Faster and Easier Radiochemical Purity Testing forSodium Iothalamate显示文摘 | Curtis R B Joanne E C Thomas J H | 1997 | Nucl Med Biol1997，24，： | 1 |
| 13 | A cerebroside from the marine fungus Microsphaerpsis olivacea (Bonord) Hhn显示文摘 | KEUSGEN M YU C M CURTIS J M | 1996 | Biochem System Ecolog1996，24，5： | 1 |
| 14 | Protective effects of mangifera indical L extract (Vimang), and its major component m angiferin, on iron-induced oxidative damage to rat serum and liver显示文摘 | Pardo-Andreu GL Barrios MF Curti C | 2008 | Pharmacol Res2008，57，： | 1 |
| 15 | Topographical control of cells显示文摘 | Curtis A Wilkinson C | 1997 | Biomaterials1997，18，24： | 1 |
| 16 | Apomixis technology development- virgin births in farmers fields显示文摘 | SPILLANE C CURTIS M D GROSSNIKLAUS U | 2004 | Nat Biotechnol2004，22，： | 1 |
| 17 | Water uptake and strength characteristics of a nanofilled resin based composite显示文摘 | CURTIS A R SHORTALL A C MARQUIS P M | 2008 | J Dent2008，36，3： | 1 |
| 18 | Expression of ezrin radixin moesin proteins in the adult subventrieular zone and the mstral migratory stream 显示文摘 | Persson A Lindwall C Curtis M A el al | 2010 | Neuroscience2010，167，2： | 1 |
| 19 | Prediction of the post-impact compressive strength of CFRP laminated composite显示文摘 | Soutis C Curtis P T | | 0，，： | 1 |
| 20 | The immunopathogenesis of chronic obstructive pulmonary disease: insights from recent research显示文摘 | Curtis J L Freeman C M Hogg J C | 2007 | Proc Am Thorac Soc2007，4，7： | 1 |
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