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| 1 | Addition of statins to the standard treatment in patients with cirrhosis:Safety and efficacy显示文摘This review summarizes the safety and efficacy of statins in patients with cirrhosis.Due to concerns about the safety of statins in patients with impaired liver function,they have recently been investigated as a potential treatment option in cirrhosis.The most clinically significant adverse event is statin-related myopathy,and this may be related to the high serum statin concentrations in the setting of severely impaired liver function.Rhabdomyolysis is the most serious and potentially life-threatening manifestation.It has recently been demonstrated that the recommended dose of simvastatin in patients with decompensated cirrhosis would be 20 mg/d because higher values,such as 40 mg/d,are associated with many adverse events,especially muscle injury.Likewise,simvastatin should not be administered to patients with Model for End-stage Liver Disease score>12 and/or Child-Pugh class C because of the high risk of severe muscle injury.Due to the pleiotropic effects,the focus on statins has shifted from being considered harmful to something useful.Through these effects,statins could prevent liver-related morbidity and mortality in cirrhotic patients.Observational studies in large populations of patients with cirrhosis have shown that treatment with statins to decrease high cholesterol levels was associated with a reduced risk of hepatic decompensation,hepatocellular carcinoma development and death.The few randomized controlled trials in patients with cirrhosis and portal hypertension showed that statins lower portal pressure,quite likely through a reduction in hepatic resistance.Another large randomized controlled trial in patients with variceal bleeding showed that simvastatin in addition to standard of care did not prevent rebleeding but improved survival rate.Despite these encouraging outcomes,the quality of the evidence regarding the use of statins is low or very low due to the observational characteristics of most of the studies involved.Therefore,it is advisable to perform further randomized controlled trials on a large series of patients with hard clinical endpoints,using different statin types and varying doses.The objectives would be to prevent liver-related morbidity and mortality rather than treating cirrhosis complications to take additional information that makes it possible to add statins to the standard of care of these patients. | Alberto E Muñoz Florencia D Pollarsky Mónica Marino Mariano Cartier Horacio Vázquez Pablo Salgado Gustavo Romero | 2021 | World Journal of Gastroenterology2021，27，28： | 4 |
| 2 | The phosphatidylinositol 3-Kinase/mTor pathway as a therapeutic target for brain aging and neurodegeneration显示文摘 | Heras-Sandoval D Avila-Muoz E Arias C | 2011 | Pharmaceuticals2011，4，8： | 1 |
| 3 | Lumbar disc herniation in adolescence显示文摘 | Ozgen S Konya D Toktas OZ | 2007 | Pediatr Neurosurg2007，43，2： | 1 |
| 4 | Left ventricular volume reduction surgery for heart failure: a physiologic perspective 显示文摘 | Artrip JH Oz MC Burkhoff D | 2001 | J Thorac Cardiovasc Surg2001，122，： | 1 |
| 5 | ABCC8 and ABCC9: ABC transporters that regulate K+ channels显示文摘 | Joseph Bryan Alvaro Mu?oz Xinna Zhang Martina Düfer Gisela Drews Peter Krippeit-Drews Lydia Aguilar-Bryan | 2007 | Pflügers Archiv - European Journal of Physiology2007，，5： | 1 |
| 6 | The incidence and causes of erectile dysfunction after pelvic fractures associated with posterior Urethral disruption显示文摘 | Shenfeld OZ Kiselgoff D Gofrit ON et d | 2003 | J Uru12003，169，6： | 1 |
| 7 | A phosphatidylinositol 3 -kinase/Akt/mTOR pathway mediates and PTEN antagonizes tumor necrosis factor inhibition of insulin signaling through insulin receptor substrate-1显示文摘 | Ozes ON Akca H Lindsey D | 2001 | Proc Natl Acad Sci USA2001，98，8： | 1 |
| 8 | A study of cytotoxicity of novelchlorokojic acid derivatives with their antimicrobial and antiviralactivities显示文摘 | AYTEMIR M D OZ^ELIK B | 2010 | Eur J Med Chem2010，45，9： | 1 |
| 9 | Forage biomass of 22 shrub species from Monfragae Natural Park(SW Spain)assessed by log- log regression models显示文摘 | Paton D u? ez J Bao D Mu? oz A | 2002 | Journal of Arid Enviroments2002，，52： | 1 |
| 10 | Direct Cardiac Compression Devices显示文摘 | Oz MC Artrip JH Burkhoff D | 2002 | J Heart Lung Transpl2002，21，10： | 1 |
| 11 | A PI3K/Akt/mTOR pathway mediates and PTEN antagonize tumor necrosis factor inhibition of insulin signaling through insulin receptor substrate-1显示文摘 | Ozes O N Akca H Mayo L D | 2001 | PNAS2001，98，8： | 1 |
| 12 | Effect of chitosan coating combined with postharvest calcium treatment on strawberry,(Fragaria ananassa) quality during refrigerated storage显示文摘 | Hernández-Mu (n)oz P Almenar E Valeria D V | | 0，，10： | 1 |
| 13 | Efficacy of several serological tests and antigens for diagnosis of bovine brucellosis in the presence of false-positive serological results due to Yersinia enterocolitica 0:9显示文摘 | Mun oz P M Marl'n C M Gonza'lez D | 2005 | Clin Diag Lab Immunol2005，12，1： | 1 |
| 14 | In vitro treatment of HepG2 cells with saturated fatty acids reproduces mitochondrial dysfunction found in nonalcoholic steatohepatitis 显示文摘 | García-Ruiz I Solís-Muoz P Fernández-Moreira D | 2015 | Dis Model Mech2015，8，2： | 1 |
| 15 | Biochemical characterization,distribution and phylogenetic analysis of Drosophila melanogaster ryanodine and IP3 receptors,and Lhapsigargin-sensitive Ca2~ ATPase 显示文摘 | V6zquez-Martinez O Ca edo-Merino R D~az-Mu oz M | 2003 | J Cell Sci2003，116，12： | 1 |
| 16 | Lumbar disc herniation in adolescence 显示文摘 | Ozgen S Konya D Toktas OZ | 2007 | Pediatric Neurosurgery2007，43，2： | 1 |
| 17 | Routing and wavelength assignment in optical networks 显示文摘 | OZ DAGLAR A BERTSEKAS D | 2003 | IEEE/ ACM Transactions on Networking2003，11，2： | 1 |
| 18 | Failure of standard treat ment with praziquantel in two returned travelers with Schistosoma haematobium infection显示文摘 | Alonso D Mu oz J Gasc n J | 2006 | Ame J Trop Med Hyg2006，74，2： | 1 |
| 19 | The effect of propra- nolol on portal hypertension in patients with cirrhosis: a hemody- namic study显示文摘 | LEBREC D HILLON P MU?OZ C | 1982 | Hepatology1982，2，5： | 1 |
| 20 | Optimization of an equilibrium modified atmosphere packaging (EMAP) for minimally processed mandarin segments显示文摘 | Del-Valle D V Hernández-Mu(n)oz Catalá R | | 0，，03： | 1 |
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