|
|
|
题名
|
作者
|
年代
|
出处
|
被引量
|
| 1 | Safety,immunogenicity,and protection provided by unadjuvanted and adjuvanted formulations of a recombinant plant-derived virus-like particle vaccine candidate for COVID-19 in nonhuman primates显示文摘Although antivirals are important tools to control severe acute respiratory syndrome coronavirus 2(SARS-CoV-2)infection,effective vaccines are essential to control the current coronavirus disease 2019(COVID-19)pandemic.Plant-derived virus-like particle(VLP)vaccine candidates have previously demonstrated immunogenicity and efficacy against influenza.Here,we report the immunogenicity and protection induced in rhesus macaques by intramuscular injections of a VLP bearing a SARS-CoV-2 spike protein(CoVLP)vaccine candidate formulated with or without Adjuvant System 03(AS03)or cytidine-phospho-guanosine(CpG)1018.Although a single dose of the unadjuvanted CoVLP vaccine candidate stimulated humoral and cell-mediated immune responses,booster immunization(at 28 days after priming)and adjuvant administration significantly improved both responses,with higher immunogenicity and protection provided by the AS03-adjuvanted CoVLP.Fifteen micrograms of CoVLP adjuvanted with AS03 induced a polyfunctional interleukin-2(IL-2)-driven response and IL-4 expression in CD4 T cells.Animals were challenged by multiple routes(i.e.,intratracheal,intranasal,and ocular)with a total viral dose of 106 plaque-forming units of SARS-CoV-2.Lower viral replication in nasal swabs and bronchoalveolar lavage fluid(BALF)as well as fewer SARS-CoV-2-infected cells and immune cell infiltrates in the lungs concomitant with reduced levels of proinflammatory cytokines and chemotactic factors in the BALF were observed in animals immunized with the CoVLP adjuvanted with AS03.No clinical,pathologic,or virologic evidence of vaccineassociated enhanced disease was observed in vaccinated animals.The CoVLP adjuvanted with AS03 was therefore selected for vaccine development and clinical trials. | Stéphane Pillet Prabhu SArunachalam Guadalupe Andreani Nadia Golden Jane Fontenot Pyone Pyone Aye Katharina Röltgen Gabrielle Lehmicke Philipe Gobeil Charlotte Dubé Sonia Trépanier Nathalie Charland Marc-AndréD’Aoust Kasi Russell-Lodrigue Christopher Monjure Robert V.Blair Scott D.Boyd Rudolf P.Bohm Jay Rappaport François Villinger Nathalie Landry Bali Pulendran Brian J.Ward | 2022 | Cellular & Molecular Immunology2022，19，2： | 2 |
| 2 | Expression and regulation of metallothioneins in the rat epididymis显示文摘 | Cyr D G Dufresne J Pillet S | 2001 | Journal of Andrology2001，22，1： | 1 |
| 3 | 查看详情显示文摘 | Ga(e)tan A Miroshnychenko Y Wilk T Chotia A Viteau M Comparat D Pillet P Browaeys A Grangier P | | 0，，： | 1 |
| 4 | 查看详情显示文摘 | Comparat D Pillet P | | 0，，： | 1 |
| 5 | Expression and regulation of metallothioneins in the rat epididymis显示文摘 | Cyr D G Dufresne J Pillet S | 2001 | Journal of Andrology2001，22，1： | 1 |
| 6 | Construction and characterization of a particle-based thrust damping system 显示文摘 | Shah B M Pillet D Bai X M | 2009 | Journal of Sound and Vibration2009，326，35： | 1 |
| 7 | Basic rationale,current methods and future directions for molecular typing of human enterovirus显示文摘 | Nasri D Bouslama L Pillet S | | 0，，04： | 1 |
| 8 | 显示文摘 | KIM C D PILLET S WU G | 2002 | Acta Cryst2002，58，： | 1 |
| 9 | Idiotypic network mimicry and antibody catalysis: lessons for the elicitation of efficient antiidiotypic protease antibodies显示文摘 | D Pillet M Paon Ⅱ Vorobiev | 2002 | J Immunol Methods2002，269，12： | 1 |
| 10 | A study in organogenesis: the arterial supply of the anorectal region in the human embryo and fetus 显示文摘 | Bourdelat D Labbe F Pillet J | 1988 | Surg Radiol Anat1988，10，1： | 1 |
| 11 | Basic rationale, current methods and future di- rections for molecular typing of human enterovirus 显示文摘 | Nasri D Bouslama L Pillet S Bourlet T Aouni M Pozzetto B | 2007 | Ex- pert Rev Mol Diagn2007，7，4： | 1 |
| 12 | Construction and characterization of a particle-based thrust显示文摘 | Shah B M Pillet D Bai Xianming | 2009 | Journal of Sound and Vibration2009，326，： | 1 |
| 13 | Laser sources for microwave to millimeter-wave applications [Invited]显示文摘We present several laser sources dedicated to advanced microwave photonic applications.A quantum-dash mode-locked laser delivering a high-power,ultra-stable pulse train is first described.We measure a linewidth below 300 kHz at a 4.3 GHz repetition rate for an output power above 300 mW and a pulse duration of 1.1 ps after compression,making this source ideal for microwave signal sampling applications.A widely tunable(5–110 GHz),monolithic millimeter-wave transceiver based on the integration of two semiconductor distributed feedback lasers,four amplifiers,and two high-speed uni-traveling carrier photodiodes is then presented,together with its application to the wireless transmission of data at 200 Mb∕s.A frequency-agile laser source dedicated to microwave signal processing is then described.It delivers arbitrary frequency sweeps over 20 GHz with high precision and high speed(above 400 GHz∕ms).Finally,we report on a low-noise(below 1 kHz linewidth),solid-state,dual-frequency laser source.It allows independent tuning of the two frequencies in the perspective of the implementation of a tunable optoelectronic oscillator based on a high-Q optical resonator. | Gaël Kervella Jeremy Maxin Mickael Faugeron Perrine Berger Hadrien Lanctuit Gregoire Pillet Loïc Morvan Frédéric van Dijk Daniel Dolfi | 2014 | Photonics Research2014，2，4： | 0 |
您所在的机构暂未开通此部分的功能，请联系管理员