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| 1 | 尿钠排泄、血压、心血管病与死亡率的关系:社区前瞻性流行病学队列研究显示文摘WHO建议人群钠摄人<2 g/d作为预防心血管病的措施之一,但这一目标在任何国家都没有实现。该建议主要基于短期血压试验的个体水平数据,没有来自随机试验或观察性研究的关于低钠摄入与降低心血管事件的数据。前瞻性城市农村流行病学研究目前正在21个国家进行。该文对其中18个国家的数据进行分析,其中包含了临床结果数据。 | Mente A O'Donnell M Rangarajan S McQueen M Dagenais G Wielgosz A Lear S Ah STL Wei L Diaz R Avezum A Lopez-Jaramillo P Lanas F Mony P Szuba A Iqbal R Yusuf R Mohammadifard N Khatib R Yusoff K Ismail N Gulec S Rosengren A Yusufali A Kruger L Tsolekile LP Chifamba J Dans A Alhabib KF Yeates K Teo K Yusuf S 刘莉 叶鹏 | 2018 | 中华高血压杂志2018，26，12： | 29 |
| 2 | Noncontrast-enhanced MRI-based Noninvasive Score for Portal Hypertension(CHESS1802):An International Multicenter Study显示文摘Background and Aims:This study aimed to determine the performance of the non-invasive score using noncontrastenhanced MRI(CHESS-DIS score)for detecting portal hy-pertension in cirrhosis.Methods:In this international multicenter,diagnostic study(ClinicalTrials.gov,NCT03766880),patients with cirrhosis who had hepatic venous pressure gradient(HVPG)measurement and noncontrast-enhanced MRI were prospectively recruited from four university hospitals in China(n=4)and Turkey(n=1)between December 2018 and April 2019.A cohort of patients was retrospectively recruited from a university hospital in Italy between March 2015 and November 2017.After segmentation of the liver on fat-suppressed T1-weighted MRI maps,CHESS-DIS score was calculated automatically by an in-house developed code based on the quantification of liver surface nodularity.Results:A total of 149 patients were included,of which 124 were from four Chinese hospitals(training cohort)and 25 were from two international hospitals(validation cohort).A positive correlation between CHESS-DIS score and HVPG was found with the correlation coefficients of 0.36(p<0.0001)and 0.55(p<0.01)for the training and validation cohorts,respectively.The area under the receiver operating characteristic curve of CHESS-DIS score in detection of clinically significant portal hypertension(CSPH)was 0.81 and 0.9 in the training and validation cohorts,respectively.The intra-class correlation coefficients for assessing the inter-and intra-observer agreement were 0.846 and 0.841,respectively.Conclusions:A non-invasive score using noncontrast-enhanced MRI was developed and proved to be significantly correlated with invasive HVPG.Besides,this score could be used to detect CSPH in patients with cirrhosis. | Yanna Liu Tianyu Tang NecatiÖrmeci Yifei Huang Jitao Wang Xiaoguo Li Zhiwei Li Weimin An Dengxiang Liu Chunqing Zhang Changchun Liu Jinqiang Liu Chuan Liu Guangchuan Wang Cristina Mosconi Alberta Cappelli Antonio Bruno Seray Akçalar EmrecanÇelebioğlu EvrenÜstüner Sadık Bilgiç Zeynep Ellik ÖzgünÖmer Asiller Lei Li Haijun Zhang Ning Kang Dan Xu Ruiling He Yan Wang Yang Bu Ye Gu Shenghong Ju Rita Golfieri Xiaolong Qi | 2021 | Journal of Clinical and Translational Hepatology2021，9，6： | 3 |
| 3 | Prolonged feeding with guanidinoacetate, a methyl group consumer, exacerbates ethanol-induced liver injury显示文摘AIM To investigate the hypothesis that exposure to guanidinoacetate(GAA, a potent methyl-group consumer) either alone or combined with ethanol intake for a prolonged period of time would cause more advanced liver pathology thus identifying methylation defects as the initiator and stimulator for progressive liver damage.METHODS Adult male Wistar rats were fed the control or ethanolLieber De Carli diet in the absence or presence of GAA supplementation. At the end of 6 wk of the feeding regimen, various biochemical and histological analyses were conducted. RESULTS Contrary to our expectations, we observed that GAA treatment alone resulted in a histologically normal liver without evidence of hepatosteatosis despite persistence of some abnormal biochemical parameters. This protection could result from the generation of creatine from the ingested GAA. Ethanol treatment for 6 wk exhibited changes in liver methionine metabolism and persistence of histological and biochemical defects as reported before. Further, when the rats were fed the GAA-supplemented ethanol diet, similar histological and biochemical changes as observed after 2 wk of combined treatment, including inflammation, macroand micro-vesicular steatosis and a marked decrease in the methylation index were noted. In addition, rats on the combined treatment exhibited increased liver toxicity and even early fibrotic changes in a subset of animals in this group. The worsening liver pathology could be related to the profound reduction in the hepatic methylation index, an increased accumulation of GAA and the inability of creatine generated to exert its hepato-protective effects in the setting of ethanol.CONCLUSION To conclude, prolonged exposure to a methyl consumer superimposed on chronic ethanol consumption causes persistent and pronounced liver damage. | Natalia A Osna Dan Feng Murali Ganesan Priya F Maillacheruvu David J Orlicky Samuel W French Dean J Tuma Kusum K Kharbanda | 2016 | World Journal of Gastroenterology2016，22，38： | 2 |
| 4 | 显示文摘 | Goebel Dan M Watkins Ron M Jameson Kristina K | 2007 | Propul Power2007，23，3： | 1 |
| 5 | Naproxen partical design using porous starch显示文摘 | NAGATE K OKAMOTO H DAN JO K | 2001 | Drug Develop Indus Pharm2001，21，4： | 1 |
| 6 | Effect of addition fluoroethers to organic solvents for lithium ion secondary batteries 显示文摘 | NAKAJIMA T DAN K I KOH M | 2001 | Journal of Fluorine Chemistry2001，111，： | 1 |
| 7 | The symmetric multiple prize all-pay auction with complete information显示文摘 | BARUT Y DAN K | 1998 | European Journal of Political Economy1998，14，4： | 1 |
| 8 | Nitrogen managemen strategies to nitrate leaching in tile-drained Mid- western soils 显示文摘 | Dana L D Douglas L K Dan B J | 2002 | Agronomy Journal2002，94，： | 1 |
| 9 | Iron(III)-mediated atom transfer radical polymerization in the absence of any additives显示文摘 | Xue Zhigang He Dan Noh S K | 2009 | Macromolecules2009，42，8： | 1 |
| 10 | The penetration of ciprofloxacin into brochial mucosa,Lung parenchyma,and Pleural tissue after intravenous administration显示文摘 | Dan M Torossian K Weissberg D | 1993 | Eur J Clin Pharmacol1993，44，1： | 1 |
| 11 | Perception and valuations of community-based education and service by alumni at Makerere University College of Health Sciences显示文摘 | Andrew Mwanika Isaac Okullo Dan K Kaye | | 0，，01： | 1 |
| 12 | Defective DNA strand break repair causes chromosomal instability and accelerates liver carcinogenesis in mice显示文摘 | Teoh NC Dan YY Swisshelm K | | 0，，06： | 1 |
| 13 | Improved assessment of mass concrete dams using acoustic travel time tomography :part Ⅰ -theory 显示文摘 | LEONARD J B WILLIAM F K DAN M F | 2000 | Construction and Building Materials2000，14，3： | 1 |
| 14 | CD14 overexpression upregulates TNF-α-medi- ated inflammatory responses and suppresses the malignancy of gastric car- cinoma cells显示文摘 | Li K Dan Z Hu X | 2013 | Mol Cell Biochem2013，376，12： | 1 |
| 15 | Characterization of spatiotemporal stress distribution during food fracture by image texture analysis methods显示文摘 | DAN H AZUMA T KOHYAMA K | 2007 | Journal of Food Engineering2007，81，2： | 1 |
| 16 | Controlling the false discovery rate in behavior genetics research显示文摘 | Yoav Bi Dan D Greg E Neri K Ilan G | 2001 | Behavioural Brain Research2001，125，1： | 1 |
| 17 | Oxaliplatin -- induced hyperensitivityreaction displayingrnarked elevation of immunoglobulin E显示文摘 | Kitada N Dan T Takara K | 2007 | Joncol Pharm Pratt2007，13，4： | 1 |
| 18 | Improved assessment of mass concrete dams using acoustic travel time tomography: part Ⅱ-applieation显示文摘 | WILLIAM F K LEONARD J B DAN M F | 2000 | Construction and Building Materials2000，14，3： | 1 |
| 19 | Blood flow velocity changes in carotid and vertebral arteries with stellate ganglion block:measurement by magnetic resonance imaging using a direct bolus tracking method显示文摘 | Nitahara K Dan K | | 0，，： | 1 |
| 20 | Improved parallel interference canc ellation for CDMA 显示文摘 | Marvin K Simon Dan Raphaeli | 1998 | IEEE Transactions on communications1998，46，2： | 1 |
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