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| 1 | Prospective randomized controlled trial evaluating cap-assisted colonoscopy vs standard colonoscopy显示文摘AIM: To study the significance of cap-fitted colonoscopy in improving cecal intubation time and polyp detection rate. METHODS: This study was a prospective randomized controlled trial conducted from March 2008 to February 2009 in a tertiary referral hospital at Sydney. The primary end point was cecal intubation time and the secondary endpoint was polyp detection rate. Consecutive cases of total colonoscopy over a 1-year period were recruited. Randomization into either standard colonoscopy (SC) or cap-assisted colonoscopy (CAC) was performed after consent was obtained. For cases randomized to CAC, one of the three sizes of cap was used: D-201-15004 (with a diameter of 15.3 mm), D-201-14304 (14.6 mm) and D-201-12704 (13.0 mm). All of these caps were produced by Olympus Medical Systems, Japan. Independent predictors for faster cecal time and better polyp detection rate were also determined from this study. RESULTS: There were 200 cases in each group. There was no signif icant difference in terms of demographic characteristics between the two groups. CAC, when compared to the SC group, had no signif icant difference in terms of cecal intubation rate (96.0% vs 97.0%, P = 0.40) and time (9.94 ± 7.05 min vs 10.34 ± 6.82 min, P = 0.21), or polyp detection rate (32.8% vs 31.3%, P = 0.75). On the subgroup analysis, there was no significant difference in terms of cecal intubation time by trainees (88.1% vs 84.8%, P = 0.40), ileal intubation rate (82.5% vs 79.0%, P = 0.38) or total colonoscopy time (23.24 ± 13.95 min vs 22.56 ± 9.94 min, P = 0.88). On multivariate analysis, the independent determinants of faster cecal time were consultant-performed procedures (P < 0.001), male patients (P < 0.001), non-usage of hyoscine (P < 0.001) and better bowel preparation (P = 0.01). The determinants of better polyp detection rate were older age (P < 0.001), no history of previous abdominal surgery (P = 0.04), patients not having esophagogastroduodenoscopy in the same setting (P = 0.003), trainee-performed procedures (P = 0.01), usage of hyoscine (P = 0.01) and procedures performed for polyp follow-up (P = 0.01). The limitations of the study were that it was a single-center experience, no blinding was possible, and there were a large number of endoscopists. CONCLUSION: CAC did not signif icantly different from SC in term of cecal intubation time and polyp detection rate. | Hoi-Poh Tee Crispin Corte Hamdan Al-Ghamdi Emilia Prakoso John Darke Raman Chettiar Wassim Rahman Scott Davison Sean P Griffin Warwick S Selby Arthur J Kaffes | 2010 | World Journal of Gastroenterology2010，16，31： | 10 |
| 2 | Vaccination with autologons tumer antigen-pulsed dentrbutic cells in advanced gynecological malignancies,clinical and immunological evaluation of a phase Ⅰtrial显示文摘 | HAMAM D O J J DARK T W KUBLERK | 2002 | Cancer Immunol2002，51，1： | 1 |
| 3 | Landscape change and habitat availability in the southern highlands and Olympic Peninsula显示文摘 | Pearson S M Turner M G Darke J B | 1999 | Ecological Applications1999，9，4： | 1 |
| 4 | The biosynthesis of trisporic acids from β-Carotene via retinal and trisporol 显示文摘 | Austin D J J D Bullock D Darke | 1970 | Experientia1970，26，： | 1 |
| 5 | Estimation of time varying skewness and kurtosis with an application to value-at-risk显示文摘 | Dark J G | | 0，，03： | 1 |
| 6 | Dangerous drug interactions leading to hemolytic uremic syndrome following lung transplantation显示文摘 | Parissis H Gould K Dark J | 2010 | J Cardiothorac Surg2010，5，： | 1 |
| 7 | Cocaine-related fatalities in New South Wales, Australia 1993-2002 显示文摘 | Darke S Kaye S Duflou J | 2005 | Drug Alcohol Dep2005，77，2： | 1 |
| 8 | Estimation of time varying skewness and kurtosis with an application to value at risk 显示文摘 | Dark J G | 2010 | Studies in Nonlinear Dynamics & Econometrics2010，14，2： | 1 |
| 9 | A modified PCR SSP method for the identi{ication o{ ABO blood group antigens 显示文摘 | Downing J Darke C | 2003 | Eur J Immunogenet2003，30，4： | 1 |
| 10 | ICV NPY Y1 receptor agonist but not Y5 agonist induces torpor-like hypothermia in cold-acclimated Siberian hamsters显示文摘 | PELZ K M DARK J | 2007 | Am J Physiol Regul Integr Comp Physiol2007，292，6： | 1 |
| 11 | A double-blind,placebo-controlled trial of modafinil(200 mg/day)for methamphetamine dependence显示文摘 | Shearer J Darke S Rodgers C | 2009 | Addiction2009，104，2： | 1 |
| 12 | NPY Y1 receptor antagonist prevents NPY induced torporlike hypothermia in cold-acclimated Siberian hamsters显示文摘 | DARK J PELZ K M | 2008 | Am J Physiol Regul Integr Comp Physiol2008，294，1： | 1 |
| 13 | Photoperiodic regulation of body mass food intake and reproduction in meadow voles 显示文摘 | Dark J Zucker I Wade G N | 1983 | Am J Physiol-Reg I1983，245，： | 1 |
| 14 | Attempted suicide among heroin users: 12-month outcomes from the Australian Treatment Outcome Study (ATOS) 显示文摘 | Darke S Williamson A Ross J | 2005 | Drug Alcohol Depen2005，78，2： | 1 |
| 15 | Suicide among heroin users: rates, risk factors and methods 显示文摘 | Darke S Ross J | 2002 | Addiction2002，97，11： | 1 |
| 16 | Attempted suicide among en- trants to three treatment modalities for heroin dependence in the Australian treatment outcome study:prevalence and risk factors 显示文摘 | Darke S Ross J Lynskey M | 2004 | Drug and alcohol depend2004，73，： | 1 |
| 17 | Dangerous drug interactions leadingto hemolytic uremic syndrome following lung transplantation显示文摘 | Parissis H Gould K Dark J | 2010 | JCardiothorac Surg2010，5，： | 1 |
| 18 | Tungsten-bearing futile from the Kori Kollo gold mine, Bolivia 显示文摘 | Rice C M Darke K E Still J W | 1998 | Mineral Magazine1998，62，： | 1 |
| 19 | Molecular order andstructure in enzyme-resistant retrograded starch显示文摘 | GIDLEY M J COOKE D DARKE A H | 1995 | CarbohydratePolymers1995，28，1： | 1 |
| 20 | Cognitive impairment among methadone maintenance patients显示文摘 | Darke S Sims J McDonald S | 2000 | Addiction2000，95，5： | 1 |
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